Arginase I and the very low-density lipoprotein receptor are associated with phenotypic biomarkers for obesity

Oh Yoen Kim, Seung Min Lee, Ji Hyung Chung, Hyun Joo Do, Jiyoung Moon, Min-Jeong Shin

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Objective: Obesity is a serious health problem implicated in many metabolic disorders (i.e., hypertension, dyslipidemia, and cardiovascular disease). We examined whether the mRNA of tested genes were linked to blood lipid concentrations and vascular endothelial function as features of obesity. Methods: In healthy subjects (30-69 y old; normal weight, n = 22, body mass index 18.5-23 kg/m 2; overweight, n = 25, body mass index ≥23 kg/m 2) the following parameters were measured in the blood circulation: total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triacylglycerol, apolipoprotein AI, apolipoprotein B, adiponectin, high-sensitivity C-reactive protein, and soluble intercellular adhesion molecule-1. The mRNA levels of genes (arginase I [ARG1], very low-density lipoprotein receptor [VLDLR], adiponectin receptor-1 [ADIPOR1], ADIPOR2, and nitric oxide synthase-3 [NOS3]) were tested in the subjects' peripheral blood mononuclear cells. Results: The expression levels of all tested genes were investigated for their associations with the blood concentrations of each parameter. In the expression study, only ARG1 (4.5-fold) and VLDLR (4-fold) expressions were significantly upregulated in the overweight group compared with the normal-weight group. The ARG1 mRNA levels were positively associated with blood concentrations of total cholesterol, low-density lipoprotein cholesterol, apolipoprotein B, and soluble intercellular adhesion molecule-1. The VLDLR mRNA levels showed a positive relation with triacylglycerol and glucose concentrations and a negative relation with adiponectin levels. Conclusion: Significant upregulations of ARG1 and VLDLR were observed in the overweight condition and their expression levels are likely to be closely linked to the phenotypic biomarkers for obesity (disturbed lipid profiles and endothelial dysfunction).

Original languageEnglish
Pages (from-to)635-639
Number of pages5
JournalNutrition
Volume28
Issue number6
DOIs
Publication statusPublished - 2012 Jun 1

Fingerprint

Arginase
Obesity
Biomarkers
Messenger RNA
Adiponectin
Apolipoproteins B
Intercellular Adhesion Molecule-1
LDL Cholesterol
Triglycerides
Body Mass Index
Adiponectin Receptors
Cholesterol
Genes
Lipids
Weights and Measures
Blood Circulation
Apolipoprotein A-I
Dyslipidemias
Nitric Oxide Synthase
C-Reactive Protein

Keywords

  • Arginase I
  • Cardiovascular risk
  • Obesity
  • Soluble intercellular adhesion molecule-1
  • Very low-density lipoprotein receptor

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Arginase I and the very low-density lipoprotein receptor are associated with phenotypic biomarkers for obesity. / Kim, Oh Yoen; Lee, Seung Min; Chung, Ji Hyung; Do, Hyun Joo; Moon, Jiyoung; Shin, Min-Jeong.

In: Nutrition, Vol. 28, No. 6, 01.06.2012, p. 635-639.

Research output: Contribution to journalArticle

Kim, Oh Yoen ; Lee, Seung Min ; Chung, Ji Hyung ; Do, Hyun Joo ; Moon, Jiyoung ; Shin, Min-Jeong. / Arginase I and the very low-density lipoprotein receptor are associated with phenotypic biomarkers for obesity. In: Nutrition. 2012 ; Vol. 28, No. 6. pp. 635-639.
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abstract = "Objective: Obesity is a serious health problem implicated in many metabolic disorders (i.e., hypertension, dyslipidemia, and cardiovascular disease). We examined whether the mRNA of tested genes were linked to blood lipid concentrations and vascular endothelial function as features of obesity. Methods: In healthy subjects (30-69 y old; normal weight, n = 22, body mass index 18.5-23 kg/m 2; overweight, n = 25, body mass index ≥23 kg/m 2) the following parameters were measured in the blood circulation: total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triacylglycerol, apolipoprotein AI, apolipoprotein B, adiponectin, high-sensitivity C-reactive protein, and soluble intercellular adhesion molecule-1. The mRNA levels of genes (arginase I [ARG1], very low-density lipoprotein receptor [VLDLR], adiponectin receptor-1 [ADIPOR1], ADIPOR2, and nitric oxide synthase-3 [NOS3]) were tested in the subjects' peripheral blood mononuclear cells. Results: The expression levels of all tested genes were investigated for their associations with the blood concentrations of each parameter. In the expression study, only ARG1 (4.5-fold) and VLDLR (4-fold) expressions were significantly upregulated in the overweight group compared with the normal-weight group. The ARG1 mRNA levels were positively associated with blood concentrations of total cholesterol, low-density lipoprotein cholesterol, apolipoprotein B, and soluble intercellular adhesion molecule-1. The VLDLR mRNA levels showed a positive relation with triacylglycerol and glucose concentrations and a negative relation with adiponectin levels. Conclusion: Significant upregulations of ARG1 and VLDLR were observed in the overweight condition and their expression levels are likely to be closely linked to the phenotypic biomarkers for obesity (disturbed lipid profiles and endothelial dysfunction).",
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AU - Kim, Oh Yoen

AU - Lee, Seung Min

AU - Chung, Ji Hyung

AU - Do, Hyun Joo

AU - Moon, Jiyoung

AU - Shin, Min-Jeong

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AB - Objective: Obesity is a serious health problem implicated in many metabolic disorders (i.e., hypertension, dyslipidemia, and cardiovascular disease). We examined whether the mRNA of tested genes were linked to blood lipid concentrations and vascular endothelial function as features of obesity. Methods: In healthy subjects (30-69 y old; normal weight, n = 22, body mass index 18.5-23 kg/m 2; overweight, n = 25, body mass index ≥23 kg/m 2) the following parameters were measured in the blood circulation: total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triacylglycerol, apolipoprotein AI, apolipoprotein B, adiponectin, high-sensitivity C-reactive protein, and soluble intercellular adhesion molecule-1. The mRNA levels of genes (arginase I [ARG1], very low-density lipoprotein receptor [VLDLR], adiponectin receptor-1 [ADIPOR1], ADIPOR2, and nitric oxide synthase-3 [NOS3]) were tested in the subjects' peripheral blood mononuclear cells. Results: The expression levels of all tested genes were investigated for their associations with the blood concentrations of each parameter. In the expression study, only ARG1 (4.5-fold) and VLDLR (4-fold) expressions were significantly upregulated in the overweight group compared with the normal-weight group. The ARG1 mRNA levels were positively associated with blood concentrations of total cholesterol, low-density lipoprotein cholesterol, apolipoprotein B, and soluble intercellular adhesion molecule-1. The VLDLR mRNA levels showed a positive relation with triacylglycerol and glucose concentrations and a negative relation with adiponectin levels. Conclusion: Significant upregulations of ARG1 and VLDLR were observed in the overweight condition and their expression levels are likely to be closely linked to the phenotypic biomarkers for obesity (disturbed lipid profiles and endothelial dysfunction).

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