Aromatic and Aliphatic Apiuronides from the Bark of Cinnamomum cassia

Suk Woo Chang, Jin Su Lee, Ji Hwan Lee, Ji Young Kim, Jongki Hong, Sun Kwang Kim, Dongho Lee, Dae Sik Jang

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Cinnamomum cassia Presl (Cinnamon) has been widely cultivated in the tropical or subtropical areas, such as Yunnan, Fujian, Guandong, and Hainan in China, as well as India, Vietnam, Thailand, and Malaysia. Four new glycosides bearing apiuronic acid (1, 4, 6, and 7) and their sodium or potassium salts (2, 3, and 5), together with 31 known compounds, were isolated from a hot water extract of the bark of C. cassia via repeated chromatography. The structures of the new compounds (1-7) were determined by NMR, IR, MS, and ICP-AES data and by acid hydrolysis and sugar analysis. This is the first report of the presence of apiuronic acid glycosides. Some of the isolates were evaluated for their analgesic effects on a neuropathic pain animal model induced by paclitaxel. Cinnzeylanol (8), cinnacaside (9), kelampayoside A (10), and syringaresinol (11) showed analgesic effects against paclitaxel-induced cold allodynia.

Original languageEnglish
Pages (from-to)553-561
Number of pages9
JournalJournal of Natural Products
Issue number3
Publication statusPublished - 2021 Mar 26

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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