Aronia melanocarpa and its components demonstrate antiviral activity against influenza viruses

Sehee Park, Jin Il Kim, Ilseob Lee, Sangmoo Lee, Min Woong Hwang, Joon Yong Bae, Jun Heo, Donghwan Kim, Sang Zin Han, Man-Seong Park

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The influenza virus is highly contagious in human populations around the world and results in approximately 250,000-500,000 deaths annually. Vaccines and antiviral drugs are commonly used to protect susceptible individuals. However, the antigenic mismatch of vaccines and the emergence of resistant strains against the currently available antiviral drugs have generated an urgent necessity to develop a novel broad-spectrum anti-influenza agent. Here we report that Aronia melanocarpa (black chokeberry, Aronia), the fruit of a perennial shrub species that contains several polyphenolic constituents, possesses in vitro and in vivo efficacy against different subtypes of influenza viruses including an oseltamivir-resistant strain. These anti-influenza properties of Aronia were attributed to two constituents, ellagic acid and myricetin. In an in vivo therapeutic mouse model, Aronia, ellagic acid, and myricetin protected mice against lethal challenge. Based on these results, we suggest that Aronia is a valuable source for antiviral agents and that ellagic acid and myricetin have potential as influenza therapeutics.

Original languageEnglish
Pages (from-to)14-19
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume440
Issue number1
DOIs
Publication statusPublished - 2013 Oct 11
Externally publishedYes

Fingerprint

Photinia
Ellagic Acid
Orthomyxoviridae
Viruses
Antiviral Agents
Human Influenza
Vaccines
Oseltamivir
Fruits
Fruit
myricetin
Therapeutics
Population

Keywords

  • Antiviral
  • Influenza virus
  • Polyphenol
  • Therapeutics

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Aronia melanocarpa and its components demonstrate antiviral activity against influenza viruses. / Park, Sehee; Kim, Jin Il; Lee, Ilseob; Lee, Sangmoo; Hwang, Min Woong; Bae, Joon Yong; Heo, Jun; Kim, Donghwan; Han, Sang Zin; Park, Man-Seong.

In: Biochemical and Biophysical Research Communications, Vol. 440, No. 1, 11.10.2013, p. 14-19.

Research output: Contribution to journalArticle

Park, Sehee ; Kim, Jin Il ; Lee, Ilseob ; Lee, Sangmoo ; Hwang, Min Woong ; Bae, Joon Yong ; Heo, Jun ; Kim, Donghwan ; Han, Sang Zin ; Park, Man-Seong. / Aronia melanocarpa and its components demonstrate antiviral activity against influenza viruses. In: Biochemical and Biophysical Research Communications. 2013 ; Vol. 440, No. 1. pp. 14-19.
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