Arousal with iv epinephrine depends on the depth of anesthesia

Hye Won Shin, Young Jun Ban, Hye Won Lee, Hae Ja Lim, Suk Min Yoon, Seong Ho Chan

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Purpose: To investigate whether the depth of anesthesia affects the change in the bispectral index (BIS) caused by iv epinephrine during propofol anesthesia. Methods: Forty women undergoing elective lower abdominal surgery received a propofol target controlled infusion (TCI) to maintain a modified Observer's Assessment of Alertness/Sedation (OAA/S) score of 2 (sedation period). Subsequently anesthesia was induced with propofol TCI 5 μg·mL-1 and rocuronium 0.9 mg·kg-1, and propofol continued so as to maintain general anesthesia at a BIS of 50 (general anesthesia period). Intravenous epinephrine at a dose of 10 μg·5 mL-1 in normal saline (epinephrine group, n = 20) or normal saline 5 mL (control group, n = 20) was administered during both periods. The BIS, mean arterial pressure (MAP) and heart rate (HR) were measured immediately before, and one, two, three, four, six, eight, and ten minutes after injection. The modified OAA/S scale was evaluated during the sedation period. Results: There was no significant change in the modified OAA/S scale, BIS, or hemodynamic variables compared to preinjection values during either sedation or general anesthesia in the control group. Intravenous epinephrine increased the BIS and modified OAA/S scale during sedation, but there was no increase in BIS during general anesthesia. Increases in HR and MAP were observed during both periods after iv epinephrine. Conclusion: Intravenous epinephrine 10 μg resulted in an arousal effect and an increase in BIS during sedation, but did not change the BIS during general anesthesia. These results suggest that the arousal effect of iv epinephrine during propofol anesthesia depends on anesthetic depth.

Original languageEnglish
Pages (from-to)880-885
Number of pages6
JournalCanadian Journal of Anesthesia
Volume51
Issue number9
Publication statusPublished - 2004 Nov 1

Fingerprint

Arousal
Epinephrine
Anesthesia
Propofol
General Anesthesia
Arterial Pressure
Heart Rate
Control Groups
Anesthetics
Hemodynamics
Injections

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Arousal with iv epinephrine depends on the depth of anesthesia. / Shin, Hye Won; Ban, Young Jun; Lee, Hye Won; Lim, Hae Ja; Yoon, Suk Min; Chan, Seong Ho.

In: Canadian Journal of Anesthesia, Vol. 51, No. 9, 01.11.2004, p. 880-885.

Research output: Contribution to journalArticle

Shin, Hye Won ; Ban, Young Jun ; Lee, Hye Won ; Lim, Hae Ja ; Yoon, Suk Min ; Chan, Seong Ho. / Arousal with iv epinephrine depends on the depth of anesthesia. In: Canadian Journal of Anesthesia. 2004 ; Vol. 51, No. 9. pp. 880-885.
@article{7cf65f8dd1874db083bab1b562ea7d5e,
title = "Arousal with iv epinephrine depends on the depth of anesthesia",
abstract = "Purpose: To investigate whether the depth of anesthesia affects the change in the bispectral index (BIS) caused by iv epinephrine during propofol anesthesia. Methods: Forty women undergoing elective lower abdominal surgery received a propofol target controlled infusion (TCI) to maintain a modified Observer's Assessment of Alertness/Sedation (OAA/S) score of 2 (sedation period). Subsequently anesthesia was induced with propofol TCI 5 μg·mL-1 and rocuronium 0.9 mg·kg-1, and propofol continued so as to maintain general anesthesia at a BIS of 50 (general anesthesia period). Intravenous epinephrine at a dose of 10 μg·5 mL-1 in normal saline (epinephrine group, n = 20) or normal saline 5 mL (control group, n = 20) was administered during both periods. The BIS, mean arterial pressure (MAP) and heart rate (HR) were measured immediately before, and one, two, three, four, six, eight, and ten minutes after injection. The modified OAA/S scale was evaluated during the sedation period. Results: There was no significant change in the modified OAA/S scale, BIS, or hemodynamic variables compared to preinjection values during either sedation or general anesthesia in the control group. Intravenous epinephrine increased the BIS and modified OAA/S scale during sedation, but there was no increase in BIS during general anesthesia. Increases in HR and MAP were observed during both periods after iv epinephrine. Conclusion: Intravenous epinephrine 10 μg resulted in an arousal effect and an increase in BIS during sedation, but did not change the BIS during general anesthesia. These results suggest that the arousal effect of iv epinephrine during propofol anesthesia depends on anesthetic depth.",
author = "Shin, {Hye Won} and Ban, {Young Jun} and Lee, {Hye Won} and Lim, {Hae Ja} and Yoon, {Suk Min} and Chan, {Seong Ho}",
year = "2004",
month = "11",
day = "1",
language = "English",
volume = "51",
pages = "880--885",
journal = "Canadian Journal of Anaesthesia",
issn = "0832-610X",
publisher = "Springer New York",
number = "9",

}

TY - JOUR

T1 - Arousal with iv epinephrine depends on the depth of anesthesia

AU - Shin, Hye Won

AU - Ban, Young Jun

AU - Lee, Hye Won

AU - Lim, Hae Ja

AU - Yoon, Suk Min

AU - Chan, Seong Ho

PY - 2004/11/1

Y1 - 2004/11/1

N2 - Purpose: To investigate whether the depth of anesthesia affects the change in the bispectral index (BIS) caused by iv epinephrine during propofol anesthesia. Methods: Forty women undergoing elective lower abdominal surgery received a propofol target controlled infusion (TCI) to maintain a modified Observer's Assessment of Alertness/Sedation (OAA/S) score of 2 (sedation period). Subsequently anesthesia was induced with propofol TCI 5 μg·mL-1 and rocuronium 0.9 mg·kg-1, and propofol continued so as to maintain general anesthesia at a BIS of 50 (general anesthesia period). Intravenous epinephrine at a dose of 10 μg·5 mL-1 in normal saline (epinephrine group, n = 20) or normal saline 5 mL (control group, n = 20) was administered during both periods. The BIS, mean arterial pressure (MAP) and heart rate (HR) were measured immediately before, and one, two, three, four, six, eight, and ten minutes after injection. The modified OAA/S scale was evaluated during the sedation period. Results: There was no significant change in the modified OAA/S scale, BIS, or hemodynamic variables compared to preinjection values during either sedation or general anesthesia in the control group. Intravenous epinephrine increased the BIS and modified OAA/S scale during sedation, but there was no increase in BIS during general anesthesia. Increases in HR and MAP were observed during both periods after iv epinephrine. Conclusion: Intravenous epinephrine 10 μg resulted in an arousal effect and an increase in BIS during sedation, but did not change the BIS during general anesthesia. These results suggest that the arousal effect of iv epinephrine during propofol anesthesia depends on anesthetic depth.

AB - Purpose: To investigate whether the depth of anesthesia affects the change in the bispectral index (BIS) caused by iv epinephrine during propofol anesthesia. Methods: Forty women undergoing elective lower abdominal surgery received a propofol target controlled infusion (TCI) to maintain a modified Observer's Assessment of Alertness/Sedation (OAA/S) score of 2 (sedation period). Subsequently anesthesia was induced with propofol TCI 5 μg·mL-1 and rocuronium 0.9 mg·kg-1, and propofol continued so as to maintain general anesthesia at a BIS of 50 (general anesthesia period). Intravenous epinephrine at a dose of 10 μg·5 mL-1 in normal saline (epinephrine group, n = 20) or normal saline 5 mL (control group, n = 20) was administered during both periods. The BIS, mean arterial pressure (MAP) and heart rate (HR) were measured immediately before, and one, two, three, four, six, eight, and ten minutes after injection. The modified OAA/S scale was evaluated during the sedation period. Results: There was no significant change in the modified OAA/S scale, BIS, or hemodynamic variables compared to preinjection values during either sedation or general anesthesia in the control group. Intravenous epinephrine increased the BIS and modified OAA/S scale during sedation, but there was no increase in BIS during general anesthesia. Increases in HR and MAP were observed during both periods after iv epinephrine. Conclusion: Intravenous epinephrine 10 μg resulted in an arousal effect and an increase in BIS during sedation, but did not change the BIS during general anesthesia. These results suggest that the arousal effect of iv epinephrine during propofol anesthesia depends on anesthetic depth.

UR - http://www.scopus.com/inward/record.url?scp=12344302385&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=12344302385&partnerID=8YFLogxK

M3 - Article

C2 - 15525612

AN - SCOPUS:12344302385

VL - 51

SP - 880

EP - 885

JO - Canadian Journal of Anaesthesia

JF - Canadian Journal of Anaesthesia

SN - 0832-610X

IS - 9

ER -