Array type dissolved oxygen sensor and measurement system for simultaneous measurement of cellular respiration level

Jung ho Park; J. H. Chang; S. Ahn; Y. K. Pak; S. Han; James Jungho Pak

doi:10.1109/SENSOR.2009.5285960

Array type dissolved oxygen sensor and measurement system for simultaneous measurement of cellular respiration level

Jung ho Park, J. H. Chang, S. Ahn, Y. K. Pak, S. Han, James Jungho Pak

School of Electrical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Citation (Scopus)

Abstract

This paper describes a miniaturized oxygen sensor array integrated with heaters and temperature sensors and a LabVIEW-based measurement system which exactly can measure a cellular respiration level in a solution containing cells simultaneously. The designed oxygen sensor consists of Clark-type sensors, heaters, and temperature sensors of 2 x 3 array type on the substrate. 18μm PDMS was used for a permeable membrane of Clark-type sensor. The 90% response time was about 10 sec from full-oxygen (air-saturated) state to zero-oxygen (0.1M Na₂SO₃) state. The fabricated sensor showed good reproducibility for 1 hour with 3.15nA standard deviation of 108.2nA mean in the full-oxygen state and 0.14nA standard deviation of 1.33nA mean in the zero-oxygen state. Also, the fabricated sensor showed a good linearity with a correlation coefficient of 0.997. The LabVIEW-based measurement system composed to voltage supply module, amplifier module, DMM module, and temperature sensing module. In order to measure the cellular respiration level, the measurement program using LabVIEW was made. The ratio of uncoupled cellular oxygen consumption rate per coupled cellular oxygen consumption rate obtained by the fabricated sensors showed 1.96 which is almost the same as the value obtained from a commercial Oxygen-2K.

Original language	English
Title of host publication	TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems
Pages	1015-1018
Number of pages	4
DOIs	https://doi.org/10.1109/SENSOR.2009.5285960
Publication status	Published - 2009 Dec 11
Event	TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems - Denver, CO, United States Duration: 2009 Jun 21 → 2009 Jun 25

Other

Other	TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems
Country	United States
City	Denver, CO
Period	09/6/21 → 09/6/25

Keywords

Cellular respiration
LabVIEW
Oxygen sensor
PDMS

ASJC Scopus subject areas

Hardware and Architecture
Electrical and Electronic Engineering

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Park, J. H., Chang, J. H., Ahn, S., Pak, Y. K., Han, S., & Pak, J. J. (2009). Array type dissolved oxygen sensor and measurement system for simultaneous measurement of cellular respiration level. In TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems (pp. 1015-1018). [5285960] https://doi.org/10.1109/SENSOR.2009.5285960

Array type dissolved oxygen sensor and measurement system for simultaneous measurement of cellular respiration level. / Park, Jung ho; Chang, J. H.; Ahn, S.; Pak, Y. K.; Han, S.; Pak, James Jungho.

TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems. 2009. p. 1015-1018 5285960.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Park, JH, Chang, JH, Ahn, S, Pak, YK, Han, S & Pak, JJ 2009, Array type dissolved oxygen sensor and measurement system for simultaneous measurement of cellular respiration level. in TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems., 5285960, pp. 1015-1018, TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems, Denver, CO, United States, 09/6/21. https://doi.org/10.1109/SENSOR.2009.5285960

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abstract = "This paper describes a miniaturized oxygen sensor array integrated with heaters and temperature sensors and a LabVIEW-based measurement system which exactly can measure a cellular respiration level in a solution containing cells simultaneously. The designed oxygen sensor consists of Clark-type sensors, heaters, and temperature sensors of 2 x 3 array type on the substrate. 18μm PDMS was used for a permeable membrane of Clark-type sensor. The 90% response time was about 10 sec from full-oxygen (air-saturated) state to zero-oxygen (0.1M Na2SO3) state. The fabricated sensor showed good reproducibility for 1 hour with 3.15nA standard deviation of 108.2nA mean in the full-oxygen state and 0.14nA standard deviation of 1.33nA mean in the zero-oxygen state. Also, the fabricated sensor showed a good linearity with a correlation coefficient of 0.997. The LabVIEW-based measurement system composed to voltage supply module, amplifier module, DMM module, and temperature sensing module. In order to measure the cellular respiration level, the measurement program using LabVIEW was made. The ratio of uncoupled cellular oxygen consumption rate per coupled cellular oxygen consumption rate obtained by the fabricated sensors showed 1.96 which is almost the same as the value obtained from a commercial Oxygen-2K.",

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AB - This paper describes a miniaturized oxygen sensor array integrated with heaters and temperature sensors and a LabVIEW-based measurement system which exactly can measure a cellular respiration level in a solution containing cells simultaneously. The designed oxygen sensor consists of Clark-type sensors, heaters, and temperature sensors of 2 x 3 array type on the substrate. 18μm PDMS was used for a permeable membrane of Clark-type sensor. The 90% response time was about 10 sec from full-oxygen (air-saturated) state to zero-oxygen (0.1M Na2SO3) state. The fabricated sensor showed good reproducibility for 1 hour with 3.15nA standard deviation of 108.2nA mean in the full-oxygen state and 0.14nA standard deviation of 1.33nA mean in the zero-oxygen state. Also, the fabricated sensor showed a good linearity with a correlation coefficient of 0.997. The LabVIEW-based measurement system composed to voltage supply module, amplifier module, DMM module, and temperature sensing module. In order to measure the cellular respiration level, the measurement program using LabVIEW was made. The ratio of uncoupled cellular oxygen consumption rate per coupled cellular oxygen consumption rate obtained by the fabricated sensors showed 1.96 which is almost the same as the value obtained from a commercial Oxygen-2K.

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