Articular cartilage regeneration with microfracture and hyaluronic acid

Sun Woong Kang, Leela Prasad Bada, Chang Seok Kang, Jae Sun Lee, Chul Hwan Kim, Jung Ho Park, Byung Soo Kim

Research output: Contribution to journalArticlepeer-review

68 Citations (Scopus)


Microfracture used to treat articular cartilage injuries can facilitate access to stem cells in the bone marrow and stimulate cartilage regeneration. However, the regenerated cartilage is fibrocartilage as opposed to hyaline articular cartilage and is thinner than native cartilage. Following microfracture in rabbit knee cartilage defects, application of hyaluronic acid gel resulted in regeneration of a thicker, more hyaline-like cartilage. The addition of transforming growth factor-β3, an inducer of chondrogenic differentiation in mesenchymal stem cells, to the treatment with microfracture and hyaluronic acid did not significantly benefit cartilage regeneration.

Original languageEnglish
Pages (from-to)435-439
Number of pages5
JournalBiotechnology letters
Issue number3
Publication statusPublished - 2008 Mar


  • Cartilage regeneration
  • Hyaluronic acid
  • Microfracture
  • Tissue engineering
  • Transforming growth factor-beta

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology


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