Artifact removal from neurophysiological signals: Impact on intracranial and arterial pressure monitoring in traumatic brain injury

Seung Bo Lee, Hakseung Kim, Young Tak Kim, Frederick A. Zeiler, Peter Smielewski, Marek Czosnyka, Dong Joo Kim

Research output: Contribution to journalArticle

Abstract

Objective: Monitoring intracranial and arterial blood pressure (ICP and ABP, respectively) provides crucial information regarding the neurological status of patients with traumatic brain injury (TBI). However, these signals are often heavily affected by artifacts, which may significantly reduce the reliability of the clinical determinations derived from the signals. The goal of this work was to eliminate signal artifacts from continuous ICP and ABP monitoring via deep learning techniques and to assess the changes in the prognostic capacities of clinical parameters after artifact elimination. Methods: The first 24 hours of monitoring ICP and ABP in a total of 309 patients with TBI was retrospectively analyzed. An artifact elimination model for ICP and ABP was constructed via a stacked convolutional autoencoder (SCAE) and convolutional neural network (CNN) with 10-fold cross-validation tests. The prevalence and prognostic capacity of ICP- and ABP-related clinical events were compared before and after artifact elimination. Results: The proposed SCAE-CNN model exhibited reliable accuracy in eliminating ABP and ICP artifacts (net prediction rates of 97% and 94%, respectively). The prevalence of ICP- and ABP-related clinical events (i.e., systemic hypotension, intracranial hypertension, cerebral hypoperfusion, and poor cerebrovascular reactivity) all decreased significantly after artifact removal. Conclusions: The SCAE-CNN model can be reliably used to eliminate artifacts, which significantly improves the reliability and efficacy of ICP- and ABP-derived clinical parameters for prognostic determinations after TBI.

Original languageEnglish
Pages (from-to)1952-1960
Number of pages9
JournalJournal of Neurosurgery
Volume132
Issue number6
DOIs
Publication statusPublished - 2020 Jun 1

Keywords

  • Cerebral hypoperfusion
  • Convolutional neural network
  • Intracranial pressure
  • Stacked convolutional autoencoder
  • Traumatic brain injury

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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