Asc1p, a ribosomal protein, plays a pivotal role in cellular adhesion and virulence in Candida albicans

Se Woong Kim, Yoo Jin Joo, Joon Kim

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Candida albicans, the common human fungal pathogen, can switch morphology from yeast to pseudohyphal or hyphal form upon various environmental cues. It is well-known that the ability of morphological conversion and adhesive growth renders C. albicans virulent. It is noteworthy that every factor involved in the morphogenesis is known to be important for the virulence of this pathogen. To examine a functional relevance of Asc1p, a ribosomal protein, in morphogenesis and virulence, an asc1 homozygous null mutant was generated. Although a normal morphological transition of the asc1 deletion strain in liquid media was found, it did not change its morphology on solid media. Moreover, the adhesion activity and hyphal-specific gene expression were defective due to ASC1 deletion. Finally, it was found that the asc1 null mutant was avirulent in a mouse model. These results strongly suggested that Asc1p a component of the 40S ribosomal subunit and a signal transducer, plays a pivotal role in cellular adhesion and virulence through regulation of specific gene expression in C. albicans.

Original languageEnglish
Pages (from-to)842-848
Number of pages7
JournalJournal of Microbiology
Volume48
Issue number6
DOIs
Publication statusPublished - 2010 Dec 1

Fingerprint

Ribosomal Proteins
Candida albicans
Virulence
Morphogenesis
Eukaryotic Small Ribosome Subunits
Aptitude
Gene Expression Regulation
Transducers
Adhesives
Cues
Yeasts
Gene Expression
Growth

Keywords

  • adhesion
  • Asc1p
  • C. albicans
  • ribosomal protein
  • virulence

ASJC Scopus subject areas

  • Microbiology
  • Applied Microbiology and Biotechnology

Cite this

Asc1p, a ribosomal protein, plays a pivotal role in cellular adhesion and virulence in Candida albicans. / Kim, Se Woong; Joo, Yoo Jin; Kim, Joon.

In: Journal of Microbiology, Vol. 48, No. 6, 01.12.2010, p. 842-848.

Research output: Contribution to journalArticle

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