Ascending pathways for mechanical allodynia in a rat model of neuropathic pain

Seung Keun Back, June Sun Kim, Seung Kil Hong, Heung Sik Na

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


To determine what the routes by which mechanical allodynia is transmitted following peripheral nerve injury, we assessed the effects of the dorsal column (DC) lesion performed before and 2 weeks after the partial injury of nerves innervating the tail on mechanical allodynia. Ipsilateral DC lesion 2 weeks after neuropathic surgery significantly, but not completely, attenuated mechanical allodynia. In addition, the DC lesion before peripheral nerve injury did not prevent the generation of mechanical allodynia, which was completely blocked by subsequent contralateral hemisection of the spinal cord. However, unlike mechanical allodynia, DC lesion did not change thermal allodynia. These results suggest that the signals for mechanical allodynia following peripheral nerve injury are transmitted via the ipsilateral DC and the contralateral pathway(s).

Original languageEnglish
Pages (from-to)1623-1626
Number of pages4
Issue number12
Publication statusPublished - 2003 Aug 26


  • Ascending pathway
  • Dorsal column
  • Mechanical allodynia
  • Neuropathic pain

ASJC Scopus subject areas

  • Neuroscience(all)


Dive into the research topics of 'Ascending pathways for mechanical allodynia in a rat model of neuropathic pain'. Together they form a unique fingerprint.

Cite this