Ascending pathways for mechanical allodynia in a rat model of neuropathic pain

Seung Keun Back, Junesun Kim, Seung Kil Hong, Heung Sik Na

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

To determine what the routes by which mechanical allodynia is transmitted following peripheral nerve injury, we assessed the effects of the dorsal column (DC) lesion performed before and 2 weeks after the partial injury of nerves innervating the tail on mechanical allodynia. Ipsilateral DC lesion 2 weeks after neuropathic surgery significantly, but not completely, attenuated mechanical allodynia. In addition, the DC lesion before peripheral nerve injury did not prevent the generation of mechanical allodynia, which was completely blocked by subsequent contralateral hemisection of the spinal cord. However, unlike mechanical allodynia, DC lesion did not change thermal allodynia. These results suggest that the signals for mechanical allodynia following peripheral nerve injury are transmitted via the ipsilateral DC and the contralateral pathway(s).

Original languageEnglish
Pages (from-to)1623-1626
Number of pages4
JournalNeuroReport
Volume14
Issue number12
DOIs
Publication statusPublished - 2003 Aug 26

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Hyperalgesia
Neuralgia
Peripheral Nerve Injuries
Tail
Spinal Cord
Wounds and Injuries

Keywords

  • Ascending pathway
  • Dorsal column
  • Mechanical allodynia
  • Neuropathic pain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ascending pathways for mechanical allodynia in a rat model of neuropathic pain. / Back, Seung Keun; Kim, Junesun; Hong, Seung Kil; Na, Heung Sik.

In: NeuroReport, Vol. 14, No. 12, 26.08.2003, p. 1623-1626.

Research output: Contribution to journalArticle

Back, Seung Keun ; Kim, Junesun ; Hong, Seung Kil ; Na, Heung Sik. / Ascending pathways for mechanical allodynia in a rat model of neuropathic pain. In: NeuroReport. 2003 ; Vol. 14, No. 12. pp. 1623-1626.
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