Assessing the accuracy and reliability of ultrasonographic three-dimensional parathyroid volume measurement in a patient with secondary hyperparathyroidism: A comparison with the two-dimensional conventional method

Sung Hye You, Sang-Il Suh, Inseon Ryoo, Gyu Ri Son, Young Hen Lee, Hyung Suk Seo, Nam-Joon Lee, Hae Young Seol

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2 Citations (Scopus)


Purpose: The purpose of this study was to investigate the accuracy and reliability of the semiautomated ultrasonographic volume measurement tool, virtual organ computer-aided analysis (VOCAL), for measuring the volume of parathyroid glands. Methods: Volume measurements for 40 parathyroid glands were performed in patients with secondary hyperparathyroidism caused by chronic renal failure. The volume of the parathyroid glands was measured twice by experienced radiologists by two-dimensional (2D) and threedimensional (3D) methods using conventional sonograms and the VOCAL with 30° angle increments before parathyroidectomy. The specimen volume was also measured postoperatively. Intraclass correlation coefficients (ICCs) and the absolute percentage error were used for estimating the reproducibility and accuracy of the two different methods. Results: The ICC value between two measurements of the 2D method and the 3D method was 0.956 and 0.999, respectively. The mean absolute percentage error of the 2D method and the 3D VOCAL technique was 29.56% and 5.78%, respectively. For accuracy and reliability, the plots of the 3D method showed a more compact distribution than those of the 2D method on the Bland-Altman graph. Conclusion: The rotational VOCAL method for measuring the parathyroid gland is more accurate and reliable than the conventional 2D measurement. This VOCAL method could be used as a more reliable follow-up imaging modality in a patient with hyperparathyroidism.

Original languageEnglish
Pages (from-to)17-24
Number of pages8
Issue number1
Publication statusPublished - 2017 Jan 1



  • Imaging
  • Organ size
  • Parathyroid glands
  • Three-dimensional
  • Ultrasonography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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