Assessment of arterial stiffness index as a clinical parameter for atherosclerotic coronary artery disease

Seong-Mi Park, Hong Seog Seo, Hong Euy Lim, Sung Hee Shin, Chang Gyu Park, Dong Joo Oh, Young Moo Ro

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background: The aim of the present study was to assess the feasibility and usefulness of the arterial stiffness index (ASI) measured non-invasively by computerized oscillometry and by comparing it with the pulse wave velocity (PWV). Methods and Results: The study group comprised 60 consutive patients who underwent coronary angiography and whose aorto-femoral PWV were obtained with a Judkins catheter. The ASI was obtained using Cardio Vision® MS-2000 (IMDP, Las Vegas, NV, USA): (i) baseline (ASI-B); (ii) hyperemia induced by compression of the arm with cuff pressure for 5 min (ASI-H); and (iii) sublingual nitroglycerin (ASI-N). In total, 34 patients had significant coronary artery disease (CAD). The PWV and all ASI were higher in patients with CAD than in those without CAD (ASI-B, 85.9±57.8 vs 48.2±24.5, p=0.001; ASI-H, 98.1±49.8 vs 48.1±21.3, p<0.01; ASI-N, 66.7±55.7 vs 33.2±27.9, p=0.002). However, only ASI-B and ASI-H were positively correlated to the PWV (ASI-B, r=0.27, p=0.03; ASI-H, r=0.49, p=0.001; ASI-N, r=0.19, p=0.16). The ASI was increased after hyperemia in patients with CAD (ASI-H, 85.9±57.8 to 98.1±49.8, p=0.01), but not in patients without CAD (ASI-H, 48.2±24.5 to 48.1±21.3, p>0.01). After adjusting their age, only ASI-H was correlated to the presence of CAD (r=0.33, p<0.01). Conclusions: It is feasible and useful to use the ASI for detection of atherosclerotic coronary disease. The findings of ASI-H suggests that in addition to stiffening of the arterial wall itself, the impairment of flow mediated vasodilation, because of endothelial dysfunction, further increases the arterial stiffness.

Original languageEnglish
Pages (from-to)1218-1222
Number of pages5
JournalCirculation Journal
Volume69
Issue number10
DOIs
Publication statusPublished - 2005 Sep 25

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Vascular Stiffness
Coronary Artery Disease
Pulse Wave Analysis
Oscillometry
Hyperemia
Nitroglycerin
Thigh
Coronary Angiography
Vasodilation
Coronary Disease
Catheters

Keywords

  • Arterial stiffness index
  • Atherosclerotic coronary artery disease
  • CardioVision

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

Cite this

Assessment of arterial stiffness index as a clinical parameter for atherosclerotic coronary artery disease. / Park, Seong-Mi; Seo, Hong Seog; Lim, Hong Euy; Shin, Sung Hee; Park, Chang Gyu; Oh, Dong Joo; Ro, Young Moo.

In: Circulation Journal, Vol. 69, No. 10, 25.09.2005, p. 1218-1222.

Research output: Contribution to journalArticle

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T1 - Assessment of arterial stiffness index as a clinical parameter for atherosclerotic coronary artery disease

AU - Park, Seong-Mi

AU - Seo, Hong Seog

AU - Lim, Hong Euy

AU - Shin, Sung Hee

AU - Park, Chang Gyu

AU - Oh, Dong Joo

AU - Ro, Young Moo

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N2 - Background: The aim of the present study was to assess the feasibility and usefulness of the arterial stiffness index (ASI) measured non-invasively by computerized oscillometry and by comparing it with the pulse wave velocity (PWV). Methods and Results: The study group comprised 60 consutive patients who underwent coronary angiography and whose aorto-femoral PWV were obtained with a Judkins catheter. The ASI was obtained using Cardio Vision® MS-2000 (IMDP, Las Vegas, NV, USA): (i) baseline (ASI-B); (ii) hyperemia induced by compression of the arm with cuff pressure for 5 min (ASI-H); and (iii) sublingual nitroglycerin (ASI-N). In total, 34 patients had significant coronary artery disease (CAD). The PWV and all ASI were higher in patients with CAD than in those without CAD (ASI-B, 85.9±57.8 vs 48.2±24.5, p=0.001; ASI-H, 98.1±49.8 vs 48.1±21.3, p<0.01; ASI-N, 66.7±55.7 vs 33.2±27.9, p=0.002). However, only ASI-B and ASI-H were positively correlated to the PWV (ASI-B, r=0.27, p=0.03; ASI-H, r=0.49, p=0.001; ASI-N, r=0.19, p=0.16). The ASI was increased after hyperemia in patients with CAD (ASI-H, 85.9±57.8 to 98.1±49.8, p=0.01), but not in patients without CAD (ASI-H, 48.2±24.5 to 48.1±21.3, p>0.01). After adjusting their age, only ASI-H was correlated to the presence of CAD (r=0.33, p<0.01). Conclusions: It is feasible and useful to use the ASI for detection of atherosclerotic coronary disease. The findings of ASI-H suggests that in addition to stiffening of the arterial wall itself, the impairment of flow mediated vasodilation, because of endothelial dysfunction, further increases the arterial stiffness.

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