Assessment of bronchodilator responsiveness following methacholine-induced bronchoconstriction in children with asthma

Siegfried Bauer, Ha Neul Park, Hyun Suk Seo, Ji Eun Kim, Dae-Jin Song, Sang Hee Park, Ji-Tae Choung, Young Yoo, Hyung Jin Kim

Research output: Contribution to journalArticle

4 Citations (Scopus)


The aim of this study was to investigate bronchodilator responsiveness (BDR) following methacholine-induced bronchoconstriction and to determine differences in BDR according to clinical parameters in children with asthma. Methods: The methacholine challenge test was performed in 145 children with mild to moderate asthma, and the provocative concentration causing a 20% decline in FEV1 (PC20) was determined. Immediately after the challenge test, patients were asked to inhale short-acting β2-agonists (SABAs) to achieve BDR, which was assessed as the change in FEV1% predicted×100/post-methacholine FEV1% predicted. For each subject, the asthma medication, blood eosinophil count, serum total IgE, serum eosinophil cationic protein level, and skin prick test result were assessed. Results: The FEV1 (mean±SD) values of the 145 patients were 90.5±10.9% predicted, 64.2±11.5% predicted, and 86.2±11.2% predicted before and after methacholine inhalation, and following the administration of a SABA, respectively. The BDR did not differ significantly according to asthma medication, age, or gender. However, BDR in the atopy group (37.4±17.7%) was significantly higher than that in the non-atopy group (30.5±10.7%; P=0.037). Patients with blood eosinophilia (38.6± 18.1%) displayed increased BDR compared with patients without eosinophilia (32.0±13.8%; P=0.037). Conclusions: In children with mild to moderate asthma, the responsiveness to short-acting bronchodilators after methacholine-induced bronchoconstriction was not related to asthma medication, but was higher in children with atopy and/or peripheral blood eosinophilia.

Original languageEnglish
Pages (from-to)245-250
Number of pages6
JournalAllergy, Asthma and Immunology Research
Issue number4
Publication statusPublished - 2011 Oct 1



  • Asthma
  • Atopy
  • Beta-adrenergic agonist
  • Child
  • Eosinophilia
  • Methacholine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine

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