Assessment of bronchodilator responsiveness following methacholine-induced bronchoconstriction in children with asthma

Siegfried Bauer, Ha Neul Park, Hyun Suk Seo, Ji Eun Kim, Dae Jin Song, Sang Hee Park, Ji Tae Choung, Young Yoo, Hyung Jin Kim

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)

    Abstract

    The aim of this study was to investigate bronchodilator responsiveness (BDR) following methacholine-induced bronchoconstriction and to determine differences in BDR according to clinical parameters in children with asthma. Methods: The methacholine challenge test was performed in 145 children with mild to moderate asthma, and the provocative concentration causing a 20% decline in FEV1 (PC20) was determined. Immediately after the challenge test, patients were asked to inhale short-acting β2-agonists (SABAs) to achieve BDR, which was assessed as the change in FEV1% predicted×100/post-methacholine FEV1% predicted. For each subject, the asthma medication, blood eosinophil count, serum total IgE, serum eosinophil cationic protein level, and skin prick test result were assessed. Results: The FEV1 (mean±SD) values of the 145 patients were 90.5±10.9% predicted, 64.2±11.5% predicted, and 86.2±11.2% predicted before and after methacholine inhalation, and following the administration of a SABA, respectively. The BDR did not differ significantly according to asthma medication, age, or gender. However, BDR in the atopy group (37.4±17.7%) was significantly higher than that in the non-atopy group (30.5±10.7%; P=0.037). Patients with blood eosinophilia (38.6± 18.1%) displayed increased BDR compared with patients without eosinophilia (32.0±13.8%; P=0.037). Conclusions: In children with mild to moderate asthma, the responsiveness to short-acting bronchodilators after methacholine-induced bronchoconstriction was not related to asthma medication, but was higher in children with atopy and/or peripheral blood eosinophilia.

    Original languageEnglish
    Pages (from-to)245-250
    Number of pages6
    JournalAllergy, Asthma and Immunology Research
    Volume3
    Issue number4
    DOIs
    Publication statusPublished - 2011 Oct

    Keywords

    • Asthma
    • Atopy
    • Beta-adrenergic agonist
    • Child
    • Eosinophilia
    • Methacholine

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology
    • Pulmonary and Respiratory Medicine

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