Assessment of penetration of quantum dots through in vitro and in vivo human skin using the human skin equivalent model and the tape stripping method

Sang Hoon Jeong, Jae Hwan Kim, Sang Min Yi, Jung Pyo Lee, Jin Ho Kim, Kyung Hee Sohn, Kui Lea Park, Meyoung Kon Kim, Sang Wook Son

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Quantum dots (QDs) are rapidly emerging as an important class of nanoparticles (NPs) with potential applications in medicine. However, little is known about penetration of QDs through human skin. This study investigated skin penetration of QDs in both in vivo and in vitro human skin. Using the tape stripping method, this study demonstrates for the first time that QDs can actually penetrate through the stratum corneum (SC) of human skin. Transmission electron microscope (TEM) and energy diverse X-ray (EDX) analysis showed accumulation of QDs in the SC of a human skin equivalent model (HSEM) after dermal exposure to QDs. These findings suggest possible transdermal absorption of QDs after dermal exposure over a relatively long period of time.

Original languageEnglish
Pages (from-to)612-615
Number of pages4
JournalBiochemical and biophysical research communications
Volume394
Issue number3
DOIs
Publication statusPublished - 2010 Apr 9

Keywords

  • Human skin equivalent model
  • Quantum dots
  • Skin penetration
  • Stratum corneum
  • Tape stripping method

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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