Assessment of risk factors for Korean children with Kawasaki disease

Jae Jung Kim, Young Mi Hong, Sin Weon Yun, Myung Ki Han, Kyung Yil Lee, Min Seob Song, Hyoung Doo Lee, Dong Soo Kim, Sejung Sohn, Kee Soo Ha, Soo Jong Hong, Kwi Joo Kim, In Sook Park, Giyoung Jang, Jong Keuk Lee

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Kawasaki disease (KD) is the most common cause of acquired heart disease in children. Intravenous immunoglobulin (IVIG) is the standard therapy for KD, but more than 10% ofKDpatients do not respond to IVIG and are at high risk for the development of coronary artery lesions (CALs). To identify clinical and genetic risk factors associated with CAL development and IVIG nonresponsiveness, this study analyzed the clinical data for 478 Korean KD patients. Multivariate logistic regression analysis showed that incomplete KD, IVIG nonresponse, fever duration of 7 days or longer, and the CC/ACgenotypes of the rs7604693 single nucleotide polymorphism (SNP) in the PELI1 gene were significantly associated with the development of CALs, with odds ratios (ORs) ranging from 2.06 to 3.04. The risk of CAL formation was synergistically increased by the addition of individual risk factors, particularly the genetic variant in the PELI1 gene. Multivariate analysis also showed that a serum albumin level of 3.6 g/dl or lower was significantly associated with nonresponsiveness to IVIG [OR, 2.76; 95% confidence interval (CI), 1.34-5.68; P = 0.006]. Conclusively, incomplete KD, IVIG nonresponsiveness, long febrile days, and the rs7604693 genetic variant in the PELI1 gene are major risk factors for the development of CALs, whereas low serumalbumin concentration is an independent risk factor for IVIG nonresponsiveness.

Original languageEnglish
Pages (from-to)513-520
Number of pages8
JournalPediatric Cardiology
Volume33
Issue number4
DOIs
Publication statusPublished - 2012 Apr 1

Fingerprint

Mucocutaneous Lymph Node Syndrome
Intravenous Immunoglobulins
Coronary Vessels
Fever
Odds Ratio
Genes
Serum Albumin
Single Nucleotide Polymorphism
Heart Diseases
Multivariate Analysis
Logistic Models
Regression Analysis
Confidence Intervals

Keywords

  • Coronary artery lesions
  • Intravenous immunoglobulin
  • Kawasaki disease
  • Korean
  • PELI1 gene

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Cardiology and Cardiovascular Medicine

Cite this

Kim, J. J., Hong, Y. M., Yun, S. W., Han, M. K., Lee, K. Y., Song, M. S., ... Lee, J. K. (2012). Assessment of risk factors for Korean children with Kawasaki disease. Pediatric Cardiology, 33(4), 513-520. https://doi.org/10.1007/s00246-011-0143-1

Assessment of risk factors for Korean children with Kawasaki disease. / Kim, Jae Jung; Hong, Young Mi; Yun, Sin Weon; Han, Myung Ki; Lee, Kyung Yil; Song, Min Seob; Lee, Hyoung Doo; Kim, Dong Soo; Sohn, Sejung; Ha, Kee Soo; Hong, Soo Jong; Kim, Kwi Joo; Park, In Sook; Jang, Giyoung; Lee, Jong Keuk.

In: Pediatric Cardiology, Vol. 33, No. 4, 01.04.2012, p. 513-520.

Research output: Contribution to journalArticle

Kim, JJ, Hong, YM, Yun, SW, Han, MK, Lee, KY, Song, MS, Lee, HD, Kim, DS, Sohn, S, Ha, KS, Hong, SJ, Kim, KJ, Park, IS, Jang, G & Lee, JK 2012, 'Assessment of risk factors for Korean children with Kawasaki disease', Pediatric Cardiology, vol. 33, no. 4, pp. 513-520. https://doi.org/10.1007/s00246-011-0143-1
Kim JJ, Hong YM, Yun SW, Han MK, Lee KY, Song MS et al. Assessment of risk factors for Korean children with Kawasaki disease. Pediatric Cardiology. 2012 Apr 1;33(4):513-520. https://doi.org/10.1007/s00246-011-0143-1
Kim, Jae Jung ; Hong, Young Mi ; Yun, Sin Weon ; Han, Myung Ki ; Lee, Kyung Yil ; Song, Min Seob ; Lee, Hyoung Doo ; Kim, Dong Soo ; Sohn, Sejung ; Ha, Kee Soo ; Hong, Soo Jong ; Kim, Kwi Joo ; Park, In Sook ; Jang, Giyoung ; Lee, Jong Keuk. / Assessment of risk factors for Korean children with Kawasaki disease. In: Pediatric Cardiology. 2012 ; Vol. 33, No. 4. pp. 513-520.
@article{2e509ff75cc2494d8c9bd506c75902f0,
title = "Assessment of risk factors for Korean children with Kawasaki disease",
abstract = "Kawasaki disease (KD) is the most common cause of acquired heart disease in children. Intravenous immunoglobulin (IVIG) is the standard therapy for KD, but more than 10{\%} ofKDpatients do not respond to IVIG and are at high risk for the development of coronary artery lesions (CALs). To identify clinical and genetic risk factors associated with CAL development and IVIG nonresponsiveness, this study analyzed the clinical data for 478 Korean KD patients. Multivariate logistic regression analysis showed that incomplete KD, IVIG nonresponse, fever duration of 7 days or longer, and the CC/ACgenotypes of the rs7604693 single nucleotide polymorphism (SNP) in the PELI1 gene were significantly associated with the development of CALs, with odds ratios (ORs) ranging from 2.06 to 3.04. The risk of CAL formation was synergistically increased by the addition of individual risk factors, particularly the genetic variant in the PELI1 gene. Multivariate analysis also showed that a serum albumin level of 3.6 g/dl or lower was significantly associated with nonresponsiveness to IVIG [OR, 2.76; 95{\%} confidence interval (CI), 1.34-5.68; P = 0.006]. Conclusively, incomplete KD, IVIG nonresponsiveness, long febrile days, and the rs7604693 genetic variant in the PELI1 gene are major risk factors for the development of CALs, whereas low serumalbumin concentration is an independent risk factor for IVIG nonresponsiveness.",
keywords = "Coronary artery lesions, Intravenous immunoglobulin, Kawasaki disease, Korean, PELI1 gene",
author = "Kim, {Jae Jung} and Hong, {Young Mi} and Yun, {Sin Weon} and Han, {Myung Ki} and Lee, {Kyung Yil} and Song, {Min Seob} and Lee, {Hyoung Doo} and Kim, {Dong Soo} and Sejung Sohn and Ha, {Kee Soo} and Hong, {Soo Jong} and Kim, {Kwi Joo} and Park, {In Sook} and Giyoung Jang and Lee, {Jong Keuk}",
year = "2012",
month = "4",
day = "1",
doi = "10.1007/s00246-011-0143-1",
language = "English",
volume = "33",
pages = "513--520",
journal = "Pediatric Cardiology",
issn = "0172-0643",
publisher = "Springer New York",
number = "4",

}

TY - JOUR

T1 - Assessment of risk factors for Korean children with Kawasaki disease

AU - Kim, Jae Jung

AU - Hong, Young Mi

AU - Yun, Sin Weon

AU - Han, Myung Ki

AU - Lee, Kyung Yil

AU - Song, Min Seob

AU - Lee, Hyoung Doo

AU - Kim, Dong Soo

AU - Sohn, Sejung

AU - Ha, Kee Soo

AU - Hong, Soo Jong

AU - Kim, Kwi Joo

AU - Park, In Sook

AU - Jang, Giyoung

AU - Lee, Jong Keuk

PY - 2012/4/1

Y1 - 2012/4/1

N2 - Kawasaki disease (KD) is the most common cause of acquired heart disease in children. Intravenous immunoglobulin (IVIG) is the standard therapy for KD, but more than 10% ofKDpatients do not respond to IVIG and are at high risk for the development of coronary artery lesions (CALs). To identify clinical and genetic risk factors associated with CAL development and IVIG nonresponsiveness, this study analyzed the clinical data for 478 Korean KD patients. Multivariate logistic regression analysis showed that incomplete KD, IVIG nonresponse, fever duration of 7 days or longer, and the CC/ACgenotypes of the rs7604693 single nucleotide polymorphism (SNP) in the PELI1 gene were significantly associated with the development of CALs, with odds ratios (ORs) ranging from 2.06 to 3.04. The risk of CAL formation was synergistically increased by the addition of individual risk factors, particularly the genetic variant in the PELI1 gene. Multivariate analysis also showed that a serum albumin level of 3.6 g/dl or lower was significantly associated with nonresponsiveness to IVIG [OR, 2.76; 95% confidence interval (CI), 1.34-5.68; P = 0.006]. Conclusively, incomplete KD, IVIG nonresponsiveness, long febrile days, and the rs7604693 genetic variant in the PELI1 gene are major risk factors for the development of CALs, whereas low serumalbumin concentration is an independent risk factor for IVIG nonresponsiveness.

AB - Kawasaki disease (KD) is the most common cause of acquired heart disease in children. Intravenous immunoglobulin (IVIG) is the standard therapy for KD, but more than 10% ofKDpatients do not respond to IVIG and are at high risk for the development of coronary artery lesions (CALs). To identify clinical and genetic risk factors associated with CAL development and IVIG nonresponsiveness, this study analyzed the clinical data for 478 Korean KD patients. Multivariate logistic regression analysis showed that incomplete KD, IVIG nonresponse, fever duration of 7 days or longer, and the CC/ACgenotypes of the rs7604693 single nucleotide polymorphism (SNP) in the PELI1 gene were significantly associated with the development of CALs, with odds ratios (ORs) ranging from 2.06 to 3.04. The risk of CAL formation was synergistically increased by the addition of individual risk factors, particularly the genetic variant in the PELI1 gene. Multivariate analysis also showed that a serum albumin level of 3.6 g/dl or lower was significantly associated with nonresponsiveness to IVIG [OR, 2.76; 95% confidence interval (CI), 1.34-5.68; P = 0.006]. Conclusively, incomplete KD, IVIG nonresponsiveness, long febrile days, and the rs7604693 genetic variant in the PELI1 gene are major risk factors for the development of CALs, whereas low serumalbumin concentration is an independent risk factor for IVIG nonresponsiveness.

KW - Coronary artery lesions

KW - Intravenous immunoglobulin

KW - Kawasaki disease

KW - Korean

KW - PELI1 gene

UR - http://www.scopus.com/inward/record.url?scp=84863432745&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863432745&partnerID=8YFLogxK

U2 - 10.1007/s00246-011-0143-1

DO - 10.1007/s00246-011-0143-1

M3 - Article

C2 - 22105492

AN - SCOPUS:84863432745

VL - 33

SP - 513

EP - 520

JO - Pediatric Cardiology

JF - Pediatric Cardiology

SN - 0172-0643

IS - 4

ER -