Assessment of scoring systems for acute-on-chronic liver failure at predicting short-Term mortality in patients with

Hee Yeon Kim, Chang Wook Kim, Tae Yeob Kim, Do Seon Song, Dong Hyun Sinn, Eileen L. Yoon, Young Kul Jung, Ki Tae Suk, Sang Soo Lee, Chang Hyeong Lee, Tae Hun Kim, Jeong Han Kim, Hyung Joon Yim, Sung Eun Kim, Soon Koo Baik, Byung Seok Lee, Jae Young Jang, Young Seok Kim, Sang Gyune Kim, Jin Mo YangJoo Hyun Sohn, Heon Ju Lee, Seung Ha Park, Eun Hee Choi, Dong Joon Kim

Research output: Contribution to journalArticle

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Abstract

AIM To assess the performance of proposed scores specific for acute-on-chronic liver failure in predicting shortterm mortality among patients with alcoholic hepatitis. METHODS We retrospectively collected data from 264 patients with clinically diagnosed alcoholic hepatitis from January to December 2013 at 21 academic hospitals in Korea. The performance for predicting short-Term mortality was calculated for Chronic Liver Failure- Sequential Organ Failure Assessment (CLIF-SOFA), CLIF Consortium Organ Failure score (CLIF-C OFs), Maddrey's discriminant function (DF), age, bilirubin, international normalized ratio and creatinine score (ABIC), Glasgow Alcoholic Hepatitis Score (GAHS), model for end-stage liver disease (MELD), and MELD-Na. RESULTS Of 264 patients, 32 (12%) patients died within 28 d. The area under receiver operating characteristic curve of CLIF-SOFA, CLIF-C OFs, DF, ABIC, GAHS, MELD, and MELD-Na was 0.86 (0.81-0.90), 0.89 (0.84-0.92), 0.79 (0.74-0.84), 0.78 (0.72-0.83), 0.81 (0.76-0.86), 0.83 (0.78-0.88), and 0.83 (0.78-0.88), respectively, for 28-d mortality. The performance of CLIF-SOFA had no statistically significant differences for 28-d mortality. The performance of CLIF-C OFs was superior to that of DF, ABIC, and GAHS, while comparable to that of MELD and MELD-Na in predicting 28-d mortality. A CLIF-SOFA score of 8 had 78.1% sensitivity and 79.7% specificity, and CLIF-C OFs of 10 had 68.8% sensitivity and 91.4% specificity for predicting 28-d mortality. CONCLUSION CLIF-SOFA and CLIF-C OF scores performed well, with comparable predictive ability for short-Term mortality compared to the commonly used scoring systems in patients with alcoholic hepatitis.

Original languageEnglish
Pages (from-to)9205-9213
Number of pages9
JournalWorld Journal of Gastroenterology
Volume22
Issue number41
DOIs
Publication statusPublished - 2016 Nov 7

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End Stage Liver Disease
Organ Dysfunction Scores
Alcoholic Hepatitis
Mortality
Acute-On-Chronic Liver Failure
Sensitivity and Specificity
International Normalized Ratio
Korea
Bilirubin
ROC Curve
Creatinine

Keywords

  • Acute-on-chronic liver failure
  • Alcoholic hepatitis
  • Mortality
  • Prognosis
  • Scoring system

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Assessment of scoring systems for acute-on-chronic liver failure at predicting short-Term mortality in patients with. / Kim, Hee Yeon; Kim, Chang Wook; Kim, Tae Yeob; Song, Do Seon; Sinn, Dong Hyun; Yoon, Eileen L.; Jung, Young Kul; Suk, Ki Tae; Lee, Sang Soo; Lee, Chang Hyeong; Kim, Tae Hun; Kim, Jeong Han; Yim, Hyung Joon; Kim, Sung Eun; Baik, Soon Koo; Lee, Byung Seok; Jang, Jae Young; Kim, Young Seok; Kim, Sang Gyune; Yang, Jin Mo; Sohn, Joo Hyun; Lee, Heon Ju; Park, Seung Ha; Choi, Eun Hee; Kim, Dong Joon.

In: World Journal of Gastroenterology, Vol. 22, No. 41, 07.11.2016, p. 9205-9213.

Research output: Contribution to journalArticle

Kim, HY, Kim, CW, Kim, TY, Song, DS, Sinn, DH, Yoon, EL, Jung, YK, Suk, KT, Lee, SS, Lee, CH, Kim, TH, Kim, JH, Yim, HJ, Kim, SE, Baik, SK, Lee, BS, Jang, JY, Kim, YS, Kim, SG, Yang, JM, Sohn, JH, Lee, HJ, Park, SH, Choi, EH & Kim, DJ 2016, 'Assessment of scoring systems for acute-on-chronic liver failure at predicting short-Term mortality in patients with', World Journal of Gastroenterology, vol. 22, no. 41, pp. 9205-9213. https://doi.org/10.3748/wjg.v22.i41.9205
Kim, Hee Yeon ; Kim, Chang Wook ; Kim, Tae Yeob ; Song, Do Seon ; Sinn, Dong Hyun ; Yoon, Eileen L. ; Jung, Young Kul ; Suk, Ki Tae ; Lee, Sang Soo ; Lee, Chang Hyeong ; Kim, Tae Hun ; Kim, Jeong Han ; Yim, Hyung Joon ; Kim, Sung Eun ; Baik, Soon Koo ; Lee, Byung Seok ; Jang, Jae Young ; Kim, Young Seok ; Kim, Sang Gyune ; Yang, Jin Mo ; Sohn, Joo Hyun ; Lee, Heon Ju ; Park, Seung Ha ; Choi, Eun Hee ; Kim, Dong Joon. / Assessment of scoring systems for acute-on-chronic liver failure at predicting short-Term mortality in patients with. In: World Journal of Gastroenterology. 2016 ; Vol. 22, No. 41. pp. 9205-9213.
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abstract = "AIM To assess the performance of proposed scores specific for acute-on-chronic liver failure in predicting shortterm mortality among patients with alcoholic hepatitis. METHODS We retrospectively collected data from 264 patients with clinically diagnosed alcoholic hepatitis from January to December 2013 at 21 academic hospitals in Korea. The performance for predicting short-Term mortality was calculated for Chronic Liver Failure- Sequential Organ Failure Assessment (CLIF-SOFA), CLIF Consortium Organ Failure score (CLIF-C OFs), Maddrey's discriminant function (DF), age, bilirubin, international normalized ratio and creatinine score (ABIC), Glasgow Alcoholic Hepatitis Score (GAHS), model for end-stage liver disease (MELD), and MELD-Na. RESULTS Of 264 patients, 32 (12{\%}) patients died within 28 d. The area under receiver operating characteristic curve of CLIF-SOFA, CLIF-C OFs, DF, ABIC, GAHS, MELD, and MELD-Na was 0.86 (0.81-0.90), 0.89 (0.84-0.92), 0.79 (0.74-0.84), 0.78 (0.72-0.83), 0.81 (0.76-0.86), 0.83 (0.78-0.88), and 0.83 (0.78-0.88), respectively, for 28-d mortality. The performance of CLIF-SOFA had no statistically significant differences for 28-d mortality. The performance of CLIF-C OFs was superior to that of DF, ABIC, and GAHS, while comparable to that of MELD and MELD-Na in predicting 28-d mortality. A CLIF-SOFA score of 8 had 78.1{\%} sensitivity and 79.7{\%} specificity, and CLIF-C OFs of 10 had 68.8{\%} sensitivity and 91.4{\%} specificity for predicting 28-d mortality. CONCLUSION CLIF-SOFA and CLIF-C OF scores performed well, with comparable predictive ability for short-Term mortality compared to the commonly used scoring systems in patients with alcoholic hepatitis.",
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AU - Kim, Hee Yeon

AU - Kim, Chang Wook

AU - Kim, Tae Yeob

AU - Song, Do Seon

AU - Sinn, Dong Hyun

AU - Yoon, Eileen L.

AU - Jung, Young Kul

AU - Suk, Ki Tae

AU - Lee, Sang Soo

AU - Lee, Chang Hyeong

AU - Kim, Tae Hun

AU - Kim, Jeong Han

AU - Yim, Hyung Joon

AU - Kim, Sung Eun

AU - Baik, Soon Koo

AU - Lee, Byung Seok

AU - Jang, Jae Young

AU - Kim, Young Seok

AU - Kim, Sang Gyune

AU - Yang, Jin Mo

AU - Sohn, Joo Hyun

AU - Lee, Heon Ju

AU - Park, Seung Ha

AU - Choi, Eun Hee

AU - Kim, Dong Joon

PY - 2016/11/7

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N2 - AIM To assess the performance of proposed scores specific for acute-on-chronic liver failure in predicting shortterm mortality among patients with alcoholic hepatitis. METHODS We retrospectively collected data from 264 patients with clinically diagnosed alcoholic hepatitis from January to December 2013 at 21 academic hospitals in Korea. The performance for predicting short-Term mortality was calculated for Chronic Liver Failure- Sequential Organ Failure Assessment (CLIF-SOFA), CLIF Consortium Organ Failure score (CLIF-C OFs), Maddrey's discriminant function (DF), age, bilirubin, international normalized ratio and creatinine score (ABIC), Glasgow Alcoholic Hepatitis Score (GAHS), model for end-stage liver disease (MELD), and MELD-Na. RESULTS Of 264 patients, 32 (12%) patients died within 28 d. The area under receiver operating characteristic curve of CLIF-SOFA, CLIF-C OFs, DF, ABIC, GAHS, MELD, and MELD-Na was 0.86 (0.81-0.90), 0.89 (0.84-0.92), 0.79 (0.74-0.84), 0.78 (0.72-0.83), 0.81 (0.76-0.86), 0.83 (0.78-0.88), and 0.83 (0.78-0.88), respectively, for 28-d mortality. The performance of CLIF-SOFA had no statistically significant differences for 28-d mortality. The performance of CLIF-C OFs was superior to that of DF, ABIC, and GAHS, while comparable to that of MELD and MELD-Na in predicting 28-d mortality. A CLIF-SOFA score of 8 had 78.1% sensitivity and 79.7% specificity, and CLIF-C OFs of 10 had 68.8% sensitivity and 91.4% specificity for predicting 28-d mortality. CONCLUSION CLIF-SOFA and CLIF-C OF scores performed well, with comparable predictive ability for short-Term mortality compared to the commonly used scoring systems in patients with alcoholic hepatitis.

AB - AIM To assess the performance of proposed scores specific for acute-on-chronic liver failure in predicting shortterm mortality among patients with alcoholic hepatitis. METHODS We retrospectively collected data from 264 patients with clinically diagnosed alcoholic hepatitis from January to December 2013 at 21 academic hospitals in Korea. The performance for predicting short-Term mortality was calculated for Chronic Liver Failure- Sequential Organ Failure Assessment (CLIF-SOFA), CLIF Consortium Organ Failure score (CLIF-C OFs), Maddrey's discriminant function (DF), age, bilirubin, international normalized ratio and creatinine score (ABIC), Glasgow Alcoholic Hepatitis Score (GAHS), model for end-stage liver disease (MELD), and MELD-Na. RESULTS Of 264 patients, 32 (12%) patients died within 28 d. The area under receiver operating characteristic curve of CLIF-SOFA, CLIF-C OFs, DF, ABIC, GAHS, MELD, and MELD-Na was 0.86 (0.81-0.90), 0.89 (0.84-0.92), 0.79 (0.74-0.84), 0.78 (0.72-0.83), 0.81 (0.76-0.86), 0.83 (0.78-0.88), and 0.83 (0.78-0.88), respectively, for 28-d mortality. The performance of CLIF-SOFA had no statistically significant differences for 28-d mortality. The performance of CLIF-C OFs was superior to that of DF, ABIC, and GAHS, while comparable to that of MELD and MELD-Na in predicting 28-d mortality. A CLIF-SOFA score of 8 had 78.1% sensitivity and 79.7% specificity, and CLIF-C OFs of 10 had 68.8% sensitivity and 91.4% specificity for predicting 28-d mortality. CONCLUSION CLIF-SOFA and CLIF-C OF scores performed well, with comparable predictive ability for short-Term mortality compared to the commonly used scoring systems in patients with alcoholic hepatitis.

KW - Acute-on-chronic liver failure

KW - Alcoholic hepatitis

KW - Mortality

KW - Prognosis

KW - Scoring system

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