Associated Factors and Clinical Implication of Cutaneous Allodynia in Patients with Cluster Headache: A Prospective Multicentre Study

Byung Su Kim, Jeong Wook Park, Jong Hee Sohn, Mi Ji Lee, Byung Kun Kim, Min Kyung Chu, Jin Young Ahn, Yun Ju Choi, Tae Jin Song, Pil Wook Chung, Kyungmi Oh, Kwang Soo Lee, Soo Kyoung Kim, Kwang Yeol Park, Jae Myun Chung, Heui Soo Moon, Chin Sang Chung, Soo Jin Cho

Research output: Contribution to journalArticle

Abstract

Cutaneous allodynia (CA) is an abnormal pain in response to non-painful stimuli. In the present study, we sought to investigate the presence of CA, its associated factors, and its clinical implications in patients with cluster headache (CH). In this cross-sectional study, we analysed data from a prospective multicentre registry enrolling consecutive patients with CH. We identified CA during and between headache attacks using the 12-item Allodynia Symptom Checklist (ASC) administered during the CH bout period. Comorbid depression and anxiety were ascertained using the Patient Health Questionnaire (PHQ-9) and the Generalized Anxiety Disorder (GAD-7) scales. Headache impact was evaluated using the Headache Impact Test-6 (HIT-6). Of 119 eligible patients, 48 and two (40.3% and 1.7%) had CA during and between headache attacks, respectively. In univariable analyses, total CH duration, major depressive disorder (MDD), and generalized anxiety disorder (GAD) were associated with CA during headache attack. They remained significantly associated with CA during headache attack in multivariable analyses. Patients with CA during headache attack had higher headache impact (P = 0.002). A “50% responder” analysis showed no difference in outcome of acute and preventive treatment between patients with and without CA during headache attack. Patients with CH commonly experienced CA during headache attack, but not between headache attacks. CA during headache attack was associated with disease duration, depression, and anxiety.

Original languageEnglish
Article number6548
JournalScientific Reports
Volume9
Issue number1
DOIs
Publication statusPublished - 2019 Dec 1

Fingerprint

Cluster Headache
Hyperalgesia
Multicenter Studies
Headache
Prospective Studies
Skin
Anxiety Disorders
Anxiety
Depression
Major Depressive Disorder
Checklist
Registries

ASJC Scopus subject areas

  • General

Cite this

Associated Factors and Clinical Implication of Cutaneous Allodynia in Patients with Cluster Headache : A Prospective Multicentre Study. / Kim, Byung Su; Park, Jeong Wook; Sohn, Jong Hee; Lee, Mi Ji; Kim, Byung Kun; Chu, Min Kyung; Ahn, Jin Young; Choi, Yun Ju; Song, Tae Jin; Chung, Pil Wook; Oh, Kyungmi; Lee, Kwang Soo; Kim, Soo Kyoung; Park, Kwang Yeol; Chung, Jae Myun; Moon, Heui Soo; Chung, Chin Sang; Cho, Soo Jin.

In: Scientific Reports, Vol. 9, No. 1, 6548, 01.12.2019.

Research output: Contribution to journalArticle

Kim, BS, Park, JW, Sohn, JH, Lee, MJ, Kim, BK, Chu, MK, Ahn, JY, Choi, YJ, Song, TJ, Chung, PW, Oh, K, Lee, KS, Kim, SK, Park, KY, Chung, JM, Moon, HS, Chung, CS & Cho, SJ 2019, 'Associated Factors and Clinical Implication of Cutaneous Allodynia in Patients with Cluster Headache: A Prospective Multicentre Study', Scientific Reports, vol. 9, no. 1, 6548. https://doi.org/10.1038/s41598-019-43065-1
Kim, Byung Su ; Park, Jeong Wook ; Sohn, Jong Hee ; Lee, Mi Ji ; Kim, Byung Kun ; Chu, Min Kyung ; Ahn, Jin Young ; Choi, Yun Ju ; Song, Tae Jin ; Chung, Pil Wook ; Oh, Kyungmi ; Lee, Kwang Soo ; Kim, Soo Kyoung ; Park, Kwang Yeol ; Chung, Jae Myun ; Moon, Heui Soo ; Chung, Chin Sang ; Cho, Soo Jin. / Associated Factors and Clinical Implication of Cutaneous Allodynia in Patients with Cluster Headache : A Prospective Multicentre Study. In: Scientific Reports. 2019 ; Vol. 9, No. 1.
@article{c10d08c4aa704ca29cc7d041fae7a08d,
title = "Associated Factors and Clinical Implication of Cutaneous Allodynia in Patients with Cluster Headache: A Prospective Multicentre Study",
abstract = "Cutaneous allodynia (CA) is an abnormal pain in response to non-painful stimuli. In the present study, we sought to investigate the presence of CA, its associated factors, and its clinical implications in patients with cluster headache (CH). In this cross-sectional study, we analysed data from a prospective multicentre registry enrolling consecutive patients with CH. We identified CA during and between headache attacks using the 12-item Allodynia Symptom Checklist (ASC) administered during the CH bout period. Comorbid depression and anxiety were ascertained using the Patient Health Questionnaire (PHQ-9) and the Generalized Anxiety Disorder (GAD-7) scales. Headache impact was evaluated using the Headache Impact Test-6 (HIT-6). Of 119 eligible patients, 48 and two (40.3{\%} and 1.7{\%}) had CA during and between headache attacks, respectively. In univariable analyses, total CH duration, major depressive disorder (MDD), and generalized anxiety disorder (GAD) were associated with CA during headache attack. They remained significantly associated with CA during headache attack in multivariable analyses. Patients with CA during headache attack had higher headache impact (P = 0.002). A “50{\%} responder” analysis showed no difference in outcome of acute and preventive treatment between patients with and without CA during headache attack. Patients with CH commonly experienced CA during headache attack, but not between headache attacks. CA during headache attack was associated with disease duration, depression, and anxiety.",
author = "Kim, {Byung Su} and Park, {Jeong Wook} and Sohn, {Jong Hee} and Lee, {Mi Ji} and Kim, {Byung Kun} and Chu, {Min Kyung} and Ahn, {Jin Young} and Choi, {Yun Ju} and Song, {Tae Jin} and Chung, {Pil Wook} and Kyungmi Oh and Lee, {Kwang Soo} and Kim, {Soo Kyoung} and Park, {Kwang Yeol} and Chung, {Jae Myun} and Moon, {Heui Soo} and Chung, {Chin Sang} and Cho, {Soo Jin}",
year = "2019",
month = "12",
day = "1",
doi = "10.1038/s41598-019-43065-1",
language = "English",
volume = "9",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Associated Factors and Clinical Implication of Cutaneous Allodynia in Patients with Cluster Headache

T2 - A Prospective Multicentre Study

AU - Kim, Byung Su

AU - Park, Jeong Wook

AU - Sohn, Jong Hee

AU - Lee, Mi Ji

AU - Kim, Byung Kun

AU - Chu, Min Kyung

AU - Ahn, Jin Young

AU - Choi, Yun Ju

AU - Song, Tae Jin

AU - Chung, Pil Wook

AU - Oh, Kyungmi

AU - Lee, Kwang Soo

AU - Kim, Soo Kyoung

AU - Park, Kwang Yeol

AU - Chung, Jae Myun

AU - Moon, Heui Soo

AU - Chung, Chin Sang

AU - Cho, Soo Jin

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Cutaneous allodynia (CA) is an abnormal pain in response to non-painful stimuli. In the present study, we sought to investigate the presence of CA, its associated factors, and its clinical implications in patients with cluster headache (CH). In this cross-sectional study, we analysed data from a prospective multicentre registry enrolling consecutive patients with CH. We identified CA during and between headache attacks using the 12-item Allodynia Symptom Checklist (ASC) administered during the CH bout period. Comorbid depression and anxiety were ascertained using the Patient Health Questionnaire (PHQ-9) and the Generalized Anxiety Disorder (GAD-7) scales. Headache impact was evaluated using the Headache Impact Test-6 (HIT-6). Of 119 eligible patients, 48 and two (40.3% and 1.7%) had CA during and between headache attacks, respectively. In univariable analyses, total CH duration, major depressive disorder (MDD), and generalized anxiety disorder (GAD) were associated with CA during headache attack. They remained significantly associated with CA during headache attack in multivariable analyses. Patients with CA during headache attack had higher headache impact (P = 0.002). A “50% responder” analysis showed no difference in outcome of acute and preventive treatment between patients with and without CA during headache attack. Patients with CH commonly experienced CA during headache attack, but not between headache attacks. CA during headache attack was associated with disease duration, depression, and anxiety.

AB - Cutaneous allodynia (CA) is an abnormal pain in response to non-painful stimuli. In the present study, we sought to investigate the presence of CA, its associated factors, and its clinical implications in patients with cluster headache (CH). In this cross-sectional study, we analysed data from a prospective multicentre registry enrolling consecutive patients with CH. We identified CA during and between headache attacks using the 12-item Allodynia Symptom Checklist (ASC) administered during the CH bout period. Comorbid depression and anxiety were ascertained using the Patient Health Questionnaire (PHQ-9) and the Generalized Anxiety Disorder (GAD-7) scales. Headache impact was evaluated using the Headache Impact Test-6 (HIT-6). Of 119 eligible patients, 48 and two (40.3% and 1.7%) had CA during and between headache attacks, respectively. In univariable analyses, total CH duration, major depressive disorder (MDD), and generalized anxiety disorder (GAD) were associated with CA during headache attack. They remained significantly associated with CA during headache attack in multivariable analyses. Patients with CA during headache attack had higher headache impact (P = 0.002). A “50% responder” analysis showed no difference in outcome of acute and preventive treatment between patients with and without CA during headache attack. Patients with CH commonly experienced CA during headache attack, but not between headache attacks. CA during headache attack was associated with disease duration, depression, and anxiety.

UR - http://www.scopus.com/inward/record.url?scp=85064932235&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85064932235&partnerID=8YFLogxK

U2 - 10.1038/s41598-019-43065-1

DO - 10.1038/s41598-019-43065-1

M3 - Article

C2 - 31024044

AN - SCOPUS:85064932235

VL - 9

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 6548

ER -