Associated Factors and Clinical Implication of Cutaneous Allodynia in Patients with Cluster Headache: A Prospective Multicentre Study

Byung Su Kim, Jeong Wook Park, Jong Hee Sohn, Mi Ji Lee, Byung Kun Kim, Min Kyung Chu, Jin Young Ahn, Yun Ju Choi, Tae Jin Song, Pil Wook Chung, Kyungmi Oh, Kwang Soo Lee, Soo Kyoung Kim, Kwang Yeol Park, Jae Myun Chung, Heui Soo Moon, Chin Sang Chung, Soo Jin Cho

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Abstract

Cutaneous allodynia (CA) is an abnormal pain in response to non-painful stimuli. In the present study, we sought to investigate the presence of CA, its associated factors, and its clinical implications in patients with cluster headache (CH). In this cross-sectional study, we analysed data from a prospective multicentre registry enrolling consecutive patients with CH. We identified CA during and between headache attacks using the 12-item Allodynia Symptom Checklist (ASC) administered during the CH bout period. Comorbid depression and anxiety were ascertained using the Patient Health Questionnaire (PHQ-9) and the Generalized Anxiety Disorder (GAD-7) scales. Headache impact was evaluated using the Headache Impact Test-6 (HIT-6). Of 119 eligible patients, 48 and two (40.3% and 1.7%) had CA during and between headache attacks, respectively. In univariable analyses, total CH duration, major depressive disorder (MDD), and generalized anxiety disorder (GAD) were associated with CA during headache attack. They remained significantly associated with CA during headache attack in multivariable analyses. Patients with CA during headache attack had higher headache impact (P = 0.002). A “50% responder” analysis showed no difference in outcome of acute and preventive treatment between patients with and without CA during headache attack. Patients with CH commonly experienced CA during headache attack, but not between headache attacks. CA during headache attack was associated with disease duration, depression, and anxiety.

Original languageEnglish
Article number6548
JournalScientific reports
Volume9
Issue number1
DOIs
Publication statusPublished - 2019 Dec 1

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    Kim, B. S., Park, J. W., Sohn, J. H., Lee, M. J., Kim, B. K., Chu, M. K., Ahn, J. Y., Choi, Y. J., Song, T. J., Chung, P. W., Oh, K., Lee, K. S., Kim, S. K., Park, K. Y., Chung, J. M., Moon, H. S., Chung, C. S., & Cho, S. J. (2019). Associated Factors and Clinical Implication of Cutaneous Allodynia in Patients with Cluster Headache: A Prospective Multicentre Study. Scientific reports, 9(1), [6548]. https://doi.org/10.1038/s41598-019-43065-1