Associated factors for asthma severity in Korean children: A Korean childhood asthma study

Eun Lee, Dae Jin Song, Woo Kyung Kim, Dong In Suh, Hey Sung Baek, Meeyong Shin, Young Yoo, Jin Tack Kim, Ji Won Kwon, Gwang Cheon Jang, Dae Hyun Lim, Hyeon Jong Yang, Hwan Soo Kim, Ju Hee Seo, Sung Il Woo, Hyung Young Kim, Youn Ho Shin, Ju Suk Lee, Jisun Yoon, Sungsu JungMinkyu Han, Eunjin Eom, Jinho Yu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: Childhood asthma has a considerable social impact and economic burden, especially in severe asthma. This study aimed to identify the proportion of childhood asthma severity and to evaluate associated factors for greater asthma severity. Methods: This study was performed on 667 children aged 5–15 years with asthma from the nationwide 19 hospitals in the Korean childhood Asthma Study (KAS). Asthma was classified as mild intermittent, mild persistent, and moderate/severe persistent groups according to the National Asthma Education and Prevention Program recommendations. Multinomial logistic regression models were used to identify the associated factors for greater asthma severity. Results: Mild persistent asthma was most prevalent (39.0%), followed by mild intermittent (37.6%), moderate persistent (22.8%), and severe persistent asthma (0.6%). Onset later than 6 years of age (adjusted odds ratio [aOR], 1.69 for mild persistent asthma; aOR, 1.92 for moderate/severe persistent asthma) tended to increase asthma severity. Exposure to environmental tobacco smoke (aOR, 1.53 for mild persistent asthma; aOR, 1.85 for moderate/ severe persistent asthma), and current dog ownership with sensitization to dog dander (aOR, 5.86 for mild persistent asthma; aOR, 6.90 for moderate/severe persistent asthma) showed increasing trends with greater asthma severity. Lower maternal education levels (aOR, 2.32) and no usage of an air purifier in exposure to high levels of outdoor air pollution (aOR, 1.76) were associated with moderate/severe persistent asthma. Conclusions: Modification of identified environmental factors associated with greater asthma severity might help better control childhood asthma, thereby reducing the disease burden due to childhood asthma.

Original languageEnglish
Pages (from-to)86-98
Number of pages13
JournalAllergy, Asthma and Immunology Research
Volume12
Issue number1
DOIs
Publication statusPublished - 2020 Jan 1

Keywords

  • Air pollution
  • Asthma
  • Child
  • Dogs
  • Education status
  • Environmental exposure
  • Risk factor
  • Severity
  • Smoke

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine

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  • Cite this

    Lee, E., Song, D. J., Kim, W. K., Suh, D. I., Baek, H. S., Shin, M., Yoo, Y., Kim, J. T., Kwon, J. W., Jang, G. C., Lim, D. H., Yang, H. J., Kim, H. S., Seo, J. H., Woo, S. I., Kim, H. Y., Shin, Y. H., Lee, J. S., Yoon, J., ... Yu, J. (2020). Associated factors for asthma severity in Korean children: A Korean childhood asthma study. Allergy, Asthma and Immunology Research, 12(1), 86-98. https://doi.org/10.4168/aair.2020.12.1.86