Association among serum ferritin, alanine aminotransferase levels, and metabolic syndrome in Korean postmenopausal women

Kyung Mook Choi, K. W. Lee, H. Y. Kim, Ji A Seo, Sin Gon Kim, Nan Hee Kim, D. S. Choi, Sei-Hyun Baik

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40 Citations (Scopus)

Abstract

We examined the relationships among serum ferritin, alanine aminotransferase (ALT) levels, and cardiovascular risk factors of metabolic syndrome in Korean postmenopausal women. We conducted a cross-sectional study of 959 postmenopausal women without an apparent cause of liver disease. Metabolic syndrome was defined as the presence of at least 3 of the following: elevated blood pressure, low high-density lipoprotein cholesterol, elevated serum triglycerides, elevated plasma glucose, and abdominal obesity. Serum ferritin and ALT levels were found to be correlated (r = 0.374, P < .001) and to be associated with the components of metabolic syndrome. Subjects with metabolic syndrome showed significantly higher serum ferritin (74.7 ± 2.0 vs 59.6 ± 2.0 ng/mL, P < .001) and ALT levels (21.3 ± 1.6 vs 18.7 ± 1.5 IU/L, P < .001). Moreover, the greater the number of metabolic syndrome components present, the higher were the serum ferritin and ALT levels (P < .001). Multiple regression analysis showed that serum ALT levels are significantly associated with serum ferritin levels, waist circumference, fasting blood glucose, age, and white blood cell count (adjusted R2 = 0.147). Elevated iron stores were positively associated with serum ALT levels and metabolic syndrome in Korean postmenopausal women.

Original languageEnglish
Pages (from-to)1510-1514
Number of pages5
JournalMetabolism: Clinical and Experimental
Volume54
Issue number11
DOIs
Publication statusPublished - 2005 Nov 1

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Ferritins
Alanine Transaminase
Serum
Abdominal Obesity
Waist Circumference
Leukocyte Count
LDL Cholesterol
HDL Cholesterol
Blood Glucose
Liver Diseases
Fasting
Triglycerides
Iron
Cross-Sectional Studies
Regression Analysis
Blood Pressure
Glucose

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

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title = "Association among serum ferritin, alanine aminotransferase levels, and metabolic syndrome in Korean postmenopausal women",
abstract = "We examined the relationships among serum ferritin, alanine aminotransferase (ALT) levels, and cardiovascular risk factors of metabolic syndrome in Korean postmenopausal women. We conducted a cross-sectional study of 959 postmenopausal women without an apparent cause of liver disease. Metabolic syndrome was defined as the presence of at least 3 of the following: elevated blood pressure, low high-density lipoprotein cholesterol, elevated serum triglycerides, elevated plasma glucose, and abdominal obesity. Serum ferritin and ALT levels were found to be correlated (r = 0.374, P < .001) and to be associated with the components of metabolic syndrome. Subjects with metabolic syndrome showed significantly higher serum ferritin (74.7 ± 2.0 vs 59.6 ± 2.0 ng/mL, P < .001) and ALT levels (21.3 ± 1.6 vs 18.7 ± 1.5 IU/L, P < .001). Moreover, the greater the number of metabolic syndrome components present, the higher were the serum ferritin and ALT levels (P < .001). Multiple regression analysis showed that serum ALT levels are significantly associated with serum ferritin levels, waist circumference, fasting blood glucose, age, and white blood cell count (adjusted R2 = 0.147). Elevated iron stores were positively associated with serum ALT levels and metabolic syndrome in Korean postmenopausal women.",
author = "Choi, {Kyung Mook} and Lee, {K. W.} and Kim, {H. Y.} and Seo, {Ji A} and Kim, {Sin Gon} and Kim, {Nan Hee} and Choi, {D. S.} and Sei-Hyun Baik",
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T1 - Association among serum ferritin, alanine aminotransferase levels, and metabolic syndrome in Korean postmenopausal women

AU - Choi, Kyung Mook

AU - Lee, K. W.

AU - Kim, H. Y.

AU - Seo, Ji A

AU - Kim, Sin Gon

AU - Kim, Nan Hee

AU - Choi, D. S.

AU - Baik, Sei-Hyun

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N2 - We examined the relationships among serum ferritin, alanine aminotransferase (ALT) levels, and cardiovascular risk factors of metabolic syndrome in Korean postmenopausal women. We conducted a cross-sectional study of 959 postmenopausal women without an apparent cause of liver disease. Metabolic syndrome was defined as the presence of at least 3 of the following: elevated blood pressure, low high-density lipoprotein cholesterol, elevated serum triglycerides, elevated plasma glucose, and abdominal obesity. Serum ferritin and ALT levels were found to be correlated (r = 0.374, P < .001) and to be associated with the components of metabolic syndrome. Subjects with metabolic syndrome showed significantly higher serum ferritin (74.7 ± 2.0 vs 59.6 ± 2.0 ng/mL, P < .001) and ALT levels (21.3 ± 1.6 vs 18.7 ± 1.5 IU/L, P < .001). Moreover, the greater the number of metabolic syndrome components present, the higher were the serum ferritin and ALT levels (P < .001). Multiple regression analysis showed that serum ALT levels are significantly associated with serum ferritin levels, waist circumference, fasting blood glucose, age, and white blood cell count (adjusted R2 = 0.147). Elevated iron stores were positively associated with serum ALT levels and metabolic syndrome in Korean postmenopausal women.

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