Association between β2 adrenoceptor polymorphisms and atopy/serum IgE in asthmatic patients

Hyung Lee Sin Hyung Lee, Jeong Shim Jae Jeong Shim, Koo Kang Yong Koo Kang, Cheol Jeong Hye Cheol Jeong, Kyu Kim Kyung Kyu Kim, Hwan Kwon Young Hwan Kwon, Hyeong Kim Je Hyeong Kim, Yong Lee Sung Yong Lee, Ra Lee So Ra Lee, Youb Lee Sang Youb Lee, Youn Cho Jae Youn Cho, Ho In Kwang Ho In, Hwa Yoo Se Hwa Yoo, Ho Kang Kyung Ho Kang

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The β2 adrenergic receptor (β2 AR) polymorphisms occurring at amino acid position 16 (Arg to Gly), 27 (Gln to Glu), 34 (Val to Met), and 164 (Thr to Ile) are known to be functionally relevant and also disease-modifying in subjects with asthma. However the contribution of these polymorphisms to the development of the asthmatic phenotype or other markers for allergic disease remains to be established. Methods: 109 patients with bronchial asthma and 42 healthy person were included. Serum total IgE, allergen specific IgE, and skin prick test were performed to all of the subjects. β2 AR polymorphisms were checked by mutated allele specific amplification (MASA) method. Results: The results were as follows. The frequencies of β2 AR polymorphisms in asthmatic patients and healthy person were not statistically different(p>0.05). There was no association between β2 AR polymorphisms of amino acid position 16, 27, 34 and the existence of atopy among asthmatic patients(p>0.05). Between asthmatic patients with or without elevated IgE level and ̄2 AR polymorphisms of amino acid position 16, 27, 34, there was no statistically significant association(p> 0.05). Conclusion : There was no difference in frequency of the β2 AR polymorphism between asthmatic patients and healthy person. In the bronchial asthma, association of β2 AR polymorphism and atopy/serum total IgE was not found.

Original languageEnglish
Pages (from-to)826-835
Number of pages10
JournalTuberculosis and Respiratory Diseases
Volume46
Issue number6
DOIs
Publication statusPublished - 1999

Keywords

  • Asthma
  • Atopy
  • Beta-2 adrenergic receptor
  • IgE
  • Polymorphism

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

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