Association between β2 adrenoceptor polymorphisms and atopy/serum IgE in asthmatic patients

Hyung Lee Sin Hyung Lee, Jeong Shim Jae Jeong Shim, Koo Kang Yong Koo Kang, Cheol Jeong Hye Cheol Jeong, Kyu Kim Kyung Kyu Kim, Hwan Kwon Young Hwan Kwon, Je Hyeong Kim, Sung Yong Lee, Ra Lee So Ra Lee, Youb Lee Sang Youb Lee, Youn Cho Jae Youn Cho, Ho In Kwang Ho In, Hwa Yoo Se Hwa Yoo, Ho Kang Kyung Ho Kang

Research output: Contribution to journalArticle

Abstract

Background: The β2 adrenergic receptor (β2 AR) polymorphisms occurring at amino acid position 16 (Arg to Gly), 27 (Gln to Glu), 34 (Val to Met), and 164 (Thr to Ile) are known to be functionally relevant and also disease-modifying in subjects with asthma. However the contribution of these polymorphisms to the development of the asthmatic phenotype or other markers for allergic disease remains to be established. Methods: 109 patients with bronchial asthma and 42 healthy person were included. Serum total IgE, allergen specific IgE, and skin prick test were performed to all of the subjects. β2 AR polymorphisms were checked by mutated allele specific amplification (MASA) method. Results: The results were as follows. The frequencies of β2 AR polymorphisms in asthmatic patients and healthy person were not statistically different(p>0.05). There was no association between β2 AR polymorphisms of amino acid position 16, 27, 34 and the existence of atopy among asthmatic patients(p>0.05). Between asthmatic patients with or without elevated IgE level and ̄2 AR polymorphisms of amino acid position 16, 27, 34, there was no statistically significant association(p> 0.05). Conclusion : There was no difference in frequency of the β2 AR polymorphism between asthmatic patients and healthy person. In the bronchial asthma, association of β2 AR polymorphism and atopy/serum total IgE was not found.

Original languageEnglish
Pages (from-to)826-835
Number of pages10
JournalTuberculosis and Respiratory Diseases
Volume46
Issue number6
Publication statusPublished - 1999 Jan 1

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Adrenergic Receptors
Immunoglobulin E
Serum
Asthma
Amino Acids
Skin Tests
Allergens
Alleles
Phenotype

Keywords

  • Asthma
  • Atopy
  • Beta-2 adrenergic receptor
  • IgE
  • Polymorphism

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Cite this

Sin Hyung Lee, H. L., Jae Jeong Shim, J. S., Yong Koo Kang, K. K., Hye Cheol Jeong, C. J., Kyung Kyu Kim, K. K., Young Hwan Kwon, H. K., ... Kyung Ho Kang, H. K. (1999). Association between β2 adrenoceptor polymorphisms and atopy/serum IgE in asthmatic patients. Tuberculosis and Respiratory Diseases, 46(6), 826-835.

Association between β2 adrenoceptor polymorphisms and atopy/serum IgE in asthmatic patients. / Sin Hyung Lee, Hyung Lee; Jae Jeong Shim, Jeong Shim; Yong Koo Kang, Koo Kang; Hye Cheol Jeong, Cheol Jeong; Kyung Kyu Kim, Kyu Kim; Young Hwan Kwon, Hwan Kwon; Kim, Je Hyeong; Lee, Sung Yong; So Ra Lee, Ra Lee; Sang Youb Lee, Youb Lee; Jae Youn Cho, Youn Cho; Kwang Ho In, Ho In; Se Hwa Yoo, Hwa Yoo; Kyung Ho Kang, Ho Kang.

In: Tuberculosis and Respiratory Diseases, Vol. 46, No. 6, 01.01.1999, p. 826-835.

Research output: Contribution to journalArticle

Sin Hyung Lee, HL, Jae Jeong Shim, JS, Yong Koo Kang, KK, Hye Cheol Jeong, CJ, Kyung Kyu Kim, KK, Young Hwan Kwon, HK, Kim, JH, Lee, SY, So Ra Lee, RL, Sang Youb Lee, YL, Jae Youn Cho, YC, Kwang Ho In, HI, Se Hwa Yoo, HY & Kyung Ho Kang, HK 1999, 'Association between β2 adrenoceptor polymorphisms and atopy/serum IgE in asthmatic patients', Tuberculosis and Respiratory Diseases, vol. 46, no. 6, pp. 826-835.
Sin Hyung Lee HL, Jae Jeong Shim JS, Yong Koo Kang KK, Hye Cheol Jeong CJ, Kyung Kyu Kim KK, Young Hwan Kwon HK et al. Association between β2 adrenoceptor polymorphisms and atopy/serum IgE in asthmatic patients. Tuberculosis and Respiratory Diseases. 1999 Jan 1;46(6):826-835.
Sin Hyung Lee, Hyung Lee ; Jae Jeong Shim, Jeong Shim ; Yong Koo Kang, Koo Kang ; Hye Cheol Jeong, Cheol Jeong ; Kyung Kyu Kim, Kyu Kim ; Young Hwan Kwon, Hwan Kwon ; Kim, Je Hyeong ; Lee, Sung Yong ; So Ra Lee, Ra Lee ; Sang Youb Lee, Youb Lee ; Jae Youn Cho, Youn Cho ; Kwang Ho In, Ho In ; Se Hwa Yoo, Hwa Yoo ; Kyung Ho Kang, Ho Kang. / Association between β2 adrenoceptor polymorphisms and atopy/serum IgE in asthmatic patients. In: Tuberculosis and Respiratory Diseases. 1999 ; Vol. 46, No. 6. pp. 826-835.
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abstract = "Background: The β2 adrenergic receptor (β2 AR) polymorphisms occurring at amino acid position 16 (Arg to Gly), 27 (Gln to Glu), 34 (Val to Met), and 164 (Thr to Ile) are known to be functionally relevant and also disease-modifying in subjects with asthma. However the contribution of these polymorphisms to the development of the asthmatic phenotype or other markers for allergic disease remains to be established. Methods: 109 patients with bronchial asthma and 42 healthy person were included. Serum total IgE, allergen specific IgE, and skin prick test were performed to all of the subjects. β2 AR polymorphisms were checked by mutated allele specific amplification (MASA) method. Results: The results were as follows. The frequencies of β2 AR polymorphisms in asthmatic patients and healthy person were not statistically different(p>0.05). There was no association between β2 AR polymorphisms of amino acid position 16, 27, 34 and the existence of atopy among asthmatic patients(p>0.05). Between asthmatic patients with or without elevated IgE level and ̄2 AR polymorphisms of amino acid position 16, 27, 34, there was no statistically significant association(p> 0.05). Conclusion : There was no difference in frequency of the β2 AR polymorphism between asthmatic patients and healthy person. In the bronchial asthma, association of β2 AR polymorphism and atopy/serum total IgE was not found.",
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T1 - Association between β2 adrenoceptor polymorphisms and atopy/serum IgE in asthmatic patients

AU - Sin Hyung Lee, Hyung Lee

AU - Jae Jeong Shim, Jeong Shim

AU - Yong Koo Kang, Koo Kang

AU - Hye Cheol Jeong, Cheol Jeong

AU - Kyung Kyu Kim, Kyu Kim

AU - Young Hwan Kwon, Hwan Kwon

AU - Kim, Je Hyeong

AU - Lee, Sung Yong

AU - So Ra Lee, Ra Lee

AU - Sang Youb Lee, Youb Lee

AU - Jae Youn Cho, Youn Cho

AU - Kwang Ho In, Ho In

AU - Se Hwa Yoo, Hwa Yoo

AU - Kyung Ho Kang, Ho Kang

PY - 1999/1/1

Y1 - 1999/1/1

N2 - Background: The β2 adrenergic receptor (β2 AR) polymorphisms occurring at amino acid position 16 (Arg to Gly), 27 (Gln to Glu), 34 (Val to Met), and 164 (Thr to Ile) are known to be functionally relevant and also disease-modifying in subjects with asthma. However the contribution of these polymorphisms to the development of the asthmatic phenotype or other markers for allergic disease remains to be established. Methods: 109 patients with bronchial asthma and 42 healthy person were included. Serum total IgE, allergen specific IgE, and skin prick test were performed to all of the subjects. β2 AR polymorphisms were checked by mutated allele specific amplification (MASA) method. Results: The results were as follows. The frequencies of β2 AR polymorphisms in asthmatic patients and healthy person were not statistically different(p>0.05). There was no association between β2 AR polymorphisms of amino acid position 16, 27, 34 and the existence of atopy among asthmatic patients(p>0.05). Between asthmatic patients with or without elevated IgE level and ̄2 AR polymorphisms of amino acid position 16, 27, 34, there was no statistically significant association(p> 0.05). Conclusion : There was no difference in frequency of the β2 AR polymorphism between asthmatic patients and healthy person. In the bronchial asthma, association of β2 AR polymorphism and atopy/serum total IgE was not found.

AB - Background: The β2 adrenergic receptor (β2 AR) polymorphisms occurring at amino acid position 16 (Arg to Gly), 27 (Gln to Glu), 34 (Val to Met), and 164 (Thr to Ile) are known to be functionally relevant and also disease-modifying in subjects with asthma. However the contribution of these polymorphisms to the development of the asthmatic phenotype or other markers for allergic disease remains to be established. Methods: 109 patients with bronchial asthma and 42 healthy person were included. Serum total IgE, allergen specific IgE, and skin prick test were performed to all of the subjects. β2 AR polymorphisms were checked by mutated allele specific amplification (MASA) method. Results: The results were as follows. The frequencies of β2 AR polymorphisms in asthmatic patients and healthy person were not statistically different(p>0.05). There was no association between β2 AR polymorphisms of amino acid position 16, 27, 34 and the existence of atopy among asthmatic patients(p>0.05). Between asthmatic patients with or without elevated IgE level and ̄2 AR polymorphisms of amino acid position 16, 27, 34, there was no statistically significant association(p> 0.05). Conclusion : There was no difference in frequency of the β2 AR polymorphism between asthmatic patients and healthy person. In the bronchial asthma, association of β2 AR polymorphism and atopy/serum total IgE was not found.

KW - Asthma

KW - Atopy

KW - Beta-2 adrenergic receptor

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KW - Polymorphism

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