Association between -276 C/T polymorphism of the ERBB3 gene and lung cancer risk in a Korean population

Jae Sook Sung, Lihua Jin, Ukhyun Jo, Kyong Hwa Park, Yeul Hong Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background/Aim: The associations between the polymorphisms in the promoter region of the V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (ERBB3) gene and lung cancer risk were investigated. Materials and Methods: By direct sequencing, we first found two known polymorphisms (-536 A/G and -276 C/T). Further TaqMan assays and logistic regression analyses were performed in order to characterize the association between the -276 C/T polymorphism of ERBB3 and lung cancer risk in 425 patients with lung cancer and 411 healthy controls. To examine the potential effects of the -276 C/T polymorphism on ERBB3 transcription, luciferase reporter assays were performed in non-small cell lung cancer (NSCLC) cell lines. Results: The -276 C/T polymorphism was associated with the risk of lung cancer in a recessive model of never-smokers. Interestingly, the T allele conferred significantly lower promoter activity by 32% and 33% than the C allele in H2009 and H358 cell lines. Conclusion: ERBB3 promoter polymorphisms affect ERBB3 gene expression, and contribute to genetic susceptibility to lung cancer in never-smokers.

Original languageEnglish
Pages (from-to)4433-4438
Number of pages6
JournalAnticancer research
Volume32
Issue number10
Publication statusPublished - 2012 Oct 1

Keywords

  • -276 C/T polymorphism
  • ERBB3 gene
  • Korean population
  • Lung cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Association between -276 C/T polymorphism of the ERBB3 gene and lung cancer risk in a Korean population'. Together they form a unique fingerprint.

  • Cite this