Association between adipocyte fatty acid-binding protein levels and childhood obesity in Korean children

Kyung Eun Yun, Seon Mee Kim, Kyung Mook Choi, Hye Soon Park

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Adipocyte fatty acid-binding protein (A-FABP) is a newly recognized adipokine that plays a role in the development of obesity and insulin resistance in adults. We investigated the association between A-FABP levels and obesity and insulin resistance in school-aged children. One hundred sixty-one 9-year-old Korean children (80 boys and 81 girls) voluntarily participated in this study at school-based health examinations. Weight, height, waist circumference, and blood pressure were measured. Fasting plasma glucose, triglycerides, high-density lipoprotein cholesterol, insulin, and A-FABP levels were measured; and insulin resistance was estimated by the homeostasis model assessment. Subjects with higher body mass index (BMI) percentiles had correspondingly higher concentrations of A-FABP in both boys and girls. Subjects within the highest quartile of A-FABP levels had correspondingly poor metabolic risk profiles (BMI, waist circumference, triglycerides, high-density lipoprotein cholesterol, fasting insulin, and homeostasis model assessment of insulin resistance) compared with those in the lowest A-FABP quartile (P < .01). Serum A-FABP concentrations were significantly correlated with BMI (r = 0.58, P < .01) and waist circumference (r = 0.51, P < .01). However, the significant correlation between serum A-FABP and insulin resistance faded after adjustment for BMI. Adipocyte fatty acid-binding protein was closely associated with obesity or abdominal obesity in children; however, the independent relationship between A-FABP and insulin resistance in children is still unclear and remains to be determined.

Original languageEnglish
Pages (from-to)798-802
Number of pages5
JournalMetabolism: Clinical and Experimental
Volume58
Issue number6
DOIs
Publication statusPublished - 2009 Jun 1
Externally publishedYes

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Fatty Acid-Binding Proteins
Pediatric Obesity
Adipocytes
Insulin Resistance
Waist Circumference
Body Mass Index
Obesity
HDL Cholesterol
Fasting
Triglycerides
Homeostasis
Insulin
Adipokines
School Health Services
Metabolome
Abdominal Obesity
Serum
Blood Pressure
Weights and Measures
Glucose

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Association between adipocyte fatty acid-binding protein levels and childhood obesity in Korean children. / Yun, Kyung Eun; Kim, Seon Mee; Choi, Kyung Mook; Park, Hye Soon.

In: Metabolism: Clinical and Experimental, Vol. 58, No. 6, 01.06.2009, p. 798-802.

Research output: Contribution to journalArticle

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