Zusammenhang zwischen Anti-Porphyromonas-gingivalis-Antikörpern, Anti-citrulliniertes-Protein-Antikörpern und rheumatoider Arthritis: Eine Metaanalyse

Translated title of the contribution: Association between anti-Porphyromonas gingivalis antibody, anti-citrullinated protein antibodies, and rheumatoid arthritis: A meta-analysis

S. C. Bae, Young Ho Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: The aim of this study was to determine the relationship between anti-Porphyromonas gingivalis (anti-P. gingivalis) antibody levels and rheumatoid arthritis (RA) and its correlation with anti-citrullinated protein antibodies (ACPA). Methods: We performed a meta-analysis of studies comparing (a) anti-P. gingivalis antibody levels in RA patients and healthy controls and (b) the correlation coefficients between the anti-P. gingivalis antibody levels and ACPA in RA patients. Results: The study included 14 articles with 3829 RA patients and 1239 controls. Our meta-analysis showed that anti-P. gingivalis antibody levels were significantly higher in the RA group than in the control group (standardized mean difference [SMD] = 0.630, 95% CI = 0.272–0.989, p = 0.001). Subgroup analysis revealed that RA patients had significantly elevated anti-P. gingivalis antibody levels compared with healthy controls, but not compared with the non-RA control group and also not between different sample sizes. Anti-P. gingivalis antibody levels were significantly higher in the RA group than in the control group in the age-/sex-matched population, but not in the unmatched population. Anti-P. gingivalis antibody levels were significantly higher in the ACPA-positive group than in the ACPA-negative group (SMD = 0.322, 95% CI = 0.164–0.480, p = 6.4 × 10−5). Meta-analysis of the correlation coefficients showed a significant positive correlation between anti-P. gingivalis antibody levels and ACPA (correlation coefficient = 0.147, 95% CI = 0.033–0.258, p = 0.012). Conclusion: Our meta-analysis demonstrated that anti-P. gingivalis antibody levels were significantly higher in patients with RA and they were positively correlated with ACPA.

Original languageGerman
Pages (from-to)1-9
Number of pages9
JournalZeitschrift fur Rheumatologie
DOIs
Publication statusAccepted/In press - 2017 May 29

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Porphyromonas gingivalis
Meta-Analysis
Anti-Idiotypic Antibodies
Rheumatoid Arthritis
Antibodies
Proteins
Control Groups
Sample Size
Population
Arthritis

Keywords

  • Anti-citrullinated protein antibodies
  • Anti-P. gingivalis antibody
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology

Cite this

@article{2fde00b2161e428da38b17afbf3f8e17,
title = "Zusammenhang zwischen Anti-Porphyromonas-gingivalis-Antik{\"o}rpern, Anti-citrulliniertes-Protein-Antik{\"o}rpern und rheumatoider Arthritis: Eine Metaanalyse",
abstract = "Objective: The aim of this study was to determine the relationship between anti-Porphyromonas gingivalis (anti-P. gingivalis) antibody levels and rheumatoid arthritis (RA) and its correlation with anti-citrullinated protein antibodies (ACPA). Methods: We performed a meta-analysis of studies comparing (a) anti-P. gingivalis antibody levels in RA patients and healthy controls and (b) the correlation coefficients between the anti-P. gingivalis antibody levels and ACPA in RA patients. Results: The study included 14 articles with 3829 RA patients and 1239 controls. Our meta-analysis showed that anti-P. gingivalis antibody levels were significantly higher in the RA group than in the control group (standardized mean difference [SMD] = 0.630, 95{\%} CI = 0.272–0.989, p = 0.001). Subgroup analysis revealed that RA patients had significantly elevated anti-P. gingivalis antibody levels compared with healthy controls, but not compared with the non-RA control group and also not between different sample sizes. Anti-P. gingivalis antibody levels were significantly higher in the RA group than in the control group in the age-/sex-matched population, but not in the unmatched population. Anti-P. gingivalis antibody levels were significantly higher in the ACPA-positive group than in the ACPA-negative group (SMD = 0.322, 95{\%} CI = 0.164–0.480, p = 6.4 × 10−5). Meta-analysis of the correlation coefficients showed a significant positive correlation between anti-P. gingivalis antibody levels and ACPA (correlation coefficient = 0.147, 95{\%} CI = 0.033–0.258, p = 0.012). Conclusion: Our meta-analysis demonstrated that anti-P. gingivalis antibody levels were significantly higher in patients with RA and they were positively correlated with ACPA.",
keywords = "Anti-citrullinated protein antibodies, Anti-P. gingivalis antibody, Rheumatoid arthritis",
author = "Bae, {S. C.} and Lee, {Young Ho}",
year = "2017",
month = "5",
day = "29",
doi = "10.1007/s00393-017-0328-y",
language = "German",
pages = "1--9",
journal = "Zeitschrift fur Rheumatologie",
issn = "0340-1855",
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T1 - Zusammenhang zwischen Anti-Porphyromonas-gingivalis-Antikörpern, Anti-citrulliniertes-Protein-Antikörpern und rheumatoider Arthritis

T2 - Eine Metaanalyse

AU - Bae, S. C.

AU - Lee, Young Ho

PY - 2017/5/29

Y1 - 2017/5/29

N2 - Objective: The aim of this study was to determine the relationship between anti-Porphyromonas gingivalis (anti-P. gingivalis) antibody levels and rheumatoid arthritis (RA) and its correlation with anti-citrullinated protein antibodies (ACPA). Methods: We performed a meta-analysis of studies comparing (a) anti-P. gingivalis antibody levels in RA patients and healthy controls and (b) the correlation coefficients between the anti-P. gingivalis antibody levels and ACPA in RA patients. Results: The study included 14 articles with 3829 RA patients and 1239 controls. Our meta-analysis showed that anti-P. gingivalis antibody levels were significantly higher in the RA group than in the control group (standardized mean difference [SMD] = 0.630, 95% CI = 0.272–0.989, p = 0.001). Subgroup analysis revealed that RA patients had significantly elevated anti-P. gingivalis antibody levels compared with healthy controls, but not compared with the non-RA control group and also not between different sample sizes. Anti-P. gingivalis antibody levels were significantly higher in the RA group than in the control group in the age-/sex-matched population, but not in the unmatched population. Anti-P. gingivalis antibody levels were significantly higher in the ACPA-positive group than in the ACPA-negative group (SMD = 0.322, 95% CI = 0.164–0.480, p = 6.4 × 10−5). Meta-analysis of the correlation coefficients showed a significant positive correlation between anti-P. gingivalis antibody levels and ACPA (correlation coefficient = 0.147, 95% CI = 0.033–0.258, p = 0.012). Conclusion: Our meta-analysis demonstrated that anti-P. gingivalis antibody levels were significantly higher in patients with RA and they were positively correlated with ACPA.

AB - Objective: The aim of this study was to determine the relationship between anti-Porphyromonas gingivalis (anti-P. gingivalis) antibody levels and rheumatoid arthritis (RA) and its correlation with anti-citrullinated protein antibodies (ACPA). Methods: We performed a meta-analysis of studies comparing (a) anti-P. gingivalis antibody levels in RA patients and healthy controls and (b) the correlation coefficients between the anti-P. gingivalis antibody levels and ACPA in RA patients. Results: The study included 14 articles with 3829 RA patients and 1239 controls. Our meta-analysis showed that anti-P. gingivalis antibody levels were significantly higher in the RA group than in the control group (standardized mean difference [SMD] = 0.630, 95% CI = 0.272–0.989, p = 0.001). Subgroup analysis revealed that RA patients had significantly elevated anti-P. gingivalis antibody levels compared with healthy controls, but not compared with the non-RA control group and also not between different sample sizes. Anti-P. gingivalis antibody levels were significantly higher in the RA group than in the control group in the age-/sex-matched population, but not in the unmatched population. Anti-P. gingivalis antibody levels were significantly higher in the ACPA-positive group than in the ACPA-negative group (SMD = 0.322, 95% CI = 0.164–0.480, p = 6.4 × 10−5). Meta-analysis of the correlation coefficients showed a significant positive correlation between anti-P. gingivalis antibody levels and ACPA (correlation coefficient = 0.147, 95% CI = 0.033–0.258, p = 0.012). Conclusion: Our meta-analysis demonstrated that anti-P. gingivalis antibody levels were significantly higher in patients with RA and they were positively correlated with ACPA.

KW - Anti-citrullinated protein antibodies

KW - Anti-P. gingivalis antibody

KW - Rheumatoid arthritis

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