Association between arachidonate 5-lipoxygenase-activating protein (ALOX5AP) and lung function in a Korean population

M. Ro, S. Kim, J. A. Pyun, Chol Shin, N. H. Cho, J. Y. Lee, I. Koh, K. Kwack

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) plays a role in the 5-lipoxygenase (LO) pathway, which includes the LTC 4, LTD 4, LTE 4 and LTB 4. These leukotrienes are known causative factors of asthma, allergy, atopy and cardiovascular diseases. ALOX5AP lacks enzyme activity and acts by helping 5-LO function. In this study, healthy and general subjects who live in rural and urban areas of Korea were tested for the association of ALOX5AP polymorphisms with lung function. Lung function was also estimated by calculating the predicted values for forced expiratory volume in one second (FEV 1_%PRED) and the proportion of the forced vital capacity exhaled in the first second (FEV 1/FVC_PRED). The linear regression was adjusted for residence area, gender, age, height and smoking status. The analysis revealed associations between FEV 1 and the single-nucleotide polymorphism (SNP) rs9506352 and the haplotype TCAC (permuted P-value<0.05). The linkage disequilibrium block that included the significant SNPs overlapped with SNPs that were revealed previously to associate with myocardial infarction and asthma and to affect lung function. This study is the first to demonstrate the association between lung function and ALOX5AP polymorphisms in a healthy and general population.

Original languageEnglish
Pages (from-to)151-157
Number of pages7
JournalScandinavian Journal of Immunology
Volume76
Issue number2
DOIs
Publication statusPublished - 2012 Aug 1

Fingerprint

5-Lipoxygenase-Activating Proteins
Single Nucleotide Polymorphism
Arachidonate 5-Lipoxygenase
Lung
Population
Asthma
Leukotrienes
Vital Capacity
Linkage Disequilibrium
Forced Expiratory Volume
Korea
Haplotypes
Linear Models
Healthy Volunteers
Hypersensitivity
Cardiovascular Diseases
Smoking
Myocardial Infarction
Enzymes

ASJC Scopus subject areas

  • Immunology

Cite this

Association between arachidonate 5-lipoxygenase-activating protein (ALOX5AP) and lung function in a Korean population. / Ro, M.; Kim, S.; Pyun, J. A.; Shin, Chol; Cho, N. H.; Lee, J. Y.; Koh, I.; Kwack, K.

In: Scandinavian Journal of Immunology, Vol. 76, No. 2, 01.08.2012, p. 151-157.

Research output: Contribution to journalArticle

Ro, M. ; Kim, S. ; Pyun, J. A. ; Shin, Chol ; Cho, N. H. ; Lee, J. Y. ; Koh, I. ; Kwack, K. / Association between arachidonate 5-lipoxygenase-activating protein (ALOX5AP) and lung function in a Korean population. In: Scandinavian Journal of Immunology. 2012 ; Vol. 76, No. 2. pp. 151-157.
@article{dca55c39c5cf4beca12c171e9a7fd944,
title = "Association between arachidonate 5-lipoxygenase-activating protein (ALOX5AP) and lung function in a Korean population",
abstract = "Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) plays a role in the 5-lipoxygenase (LO) pathway, which includes the LTC 4, LTD 4, LTE 4 and LTB 4. These leukotrienes are known causative factors of asthma, allergy, atopy and cardiovascular diseases. ALOX5AP lacks enzyme activity and acts by helping 5-LO function. In this study, healthy and general subjects who live in rural and urban areas of Korea were tested for the association of ALOX5AP polymorphisms with lung function. Lung function was also estimated by calculating the predicted values for forced expiratory volume in one second (FEV 1_{\%}PRED) and the proportion of the forced vital capacity exhaled in the first second (FEV 1/FVC_PRED). The linear regression was adjusted for residence area, gender, age, height and smoking status. The analysis revealed associations between FEV 1 and the single-nucleotide polymorphism (SNP) rs9506352 and the haplotype TCAC (permuted P-value<0.05). The linkage disequilibrium block that included the significant SNPs overlapped with SNPs that were revealed previously to associate with myocardial infarction and asthma and to affect lung function. This study is the first to demonstrate the association between lung function and ALOX5AP polymorphisms in a healthy and general population.",
author = "M. Ro and S. Kim and Pyun, {J. A.} and Chol Shin and Cho, {N. H.} and Lee, {J. Y.} and I. Koh and K. Kwack",
year = "2012",
month = "8",
day = "1",
doi = "10.1111/j.1365-3083.2012.02712.x",
language = "English",
volume = "76",
pages = "151--157",
journal = "Scandinavian Journal of Immunology",
issn = "0300-9475",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Association between arachidonate 5-lipoxygenase-activating protein (ALOX5AP) and lung function in a Korean population

AU - Ro, M.

AU - Kim, S.

AU - Pyun, J. A.

AU - Shin, Chol

AU - Cho, N. H.

AU - Lee, J. Y.

AU - Koh, I.

AU - Kwack, K.

PY - 2012/8/1

Y1 - 2012/8/1

N2 - Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) plays a role in the 5-lipoxygenase (LO) pathway, which includes the LTC 4, LTD 4, LTE 4 and LTB 4. These leukotrienes are known causative factors of asthma, allergy, atopy and cardiovascular diseases. ALOX5AP lacks enzyme activity and acts by helping 5-LO function. In this study, healthy and general subjects who live in rural and urban areas of Korea were tested for the association of ALOX5AP polymorphisms with lung function. Lung function was also estimated by calculating the predicted values for forced expiratory volume in one second (FEV 1_%PRED) and the proportion of the forced vital capacity exhaled in the first second (FEV 1/FVC_PRED). The linear regression was adjusted for residence area, gender, age, height and smoking status. The analysis revealed associations between FEV 1 and the single-nucleotide polymorphism (SNP) rs9506352 and the haplotype TCAC (permuted P-value<0.05). The linkage disequilibrium block that included the significant SNPs overlapped with SNPs that were revealed previously to associate with myocardial infarction and asthma and to affect lung function. This study is the first to demonstrate the association between lung function and ALOX5AP polymorphisms in a healthy and general population.

AB - Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) plays a role in the 5-lipoxygenase (LO) pathway, which includes the LTC 4, LTD 4, LTE 4 and LTB 4. These leukotrienes are known causative factors of asthma, allergy, atopy and cardiovascular diseases. ALOX5AP lacks enzyme activity and acts by helping 5-LO function. In this study, healthy and general subjects who live in rural and urban areas of Korea were tested for the association of ALOX5AP polymorphisms with lung function. Lung function was also estimated by calculating the predicted values for forced expiratory volume in one second (FEV 1_%PRED) and the proportion of the forced vital capacity exhaled in the first second (FEV 1/FVC_PRED). The linear regression was adjusted for residence area, gender, age, height and smoking status. The analysis revealed associations between FEV 1 and the single-nucleotide polymorphism (SNP) rs9506352 and the haplotype TCAC (permuted P-value<0.05). The linkage disequilibrium block that included the significant SNPs overlapped with SNPs that were revealed previously to associate with myocardial infarction and asthma and to affect lung function. This study is the first to demonstrate the association between lung function and ALOX5AP polymorphisms in a healthy and general population.

UR - http://www.scopus.com/inward/record.url?scp=84864305293&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864305293&partnerID=8YFLogxK

U2 - 10.1111/j.1365-3083.2012.02712.x

DO - 10.1111/j.1365-3083.2012.02712.x

M3 - Article

C2 - 22537113

AN - SCOPUS:84864305293

VL - 76

SP - 151

EP - 157

JO - Scandinavian Journal of Immunology

JF - Scandinavian Journal of Immunology

SN - 0300-9475

IS - 2

ER -