Association between body mass index and 1-year outcome after acute myocardial infarction

Dae Won Kim, Sung Ho Her, Ha Wook Park, Mahn Won Park, Kiyuk Chang, Wook Sung Chung, Ki Bae Seung, Tae Hoon Ahn, Myung Ho Jeong, Seung-Woon Rha, Hyo Soo Kim, Hyeon Cheol Gwon, In Whan Seong, Kyung Kuk Hwang, Shung Chull Chae, Kwon Bae Kim, Young Jo Kim, Kwang Soo Cha, Seok Kyu Oh, Jei Keon Chae

Research output: Contribution to journalArticle

Abstract

Objectives Beneficial effects of overweight and obesity on mortality after acute myocardial infarction (AMI) have been described as "Body Mass Index (BMI) paradox". However, the effects of BMI is still on debate. We analyzed the association between BMI and 1-year clinical outcomes after AMI. Methods Among 13,104 AMI patients registered in Korea Acute Myocardial Infarction Registry- National Institute of Health (KAMIR-NIH) between November 2011 and December 2015, 10,568 patients who eligible for this study were classified into 3 groups according to BMI (Group 1; < 22 kg/m2, 22 . Group 2 < 26 kg/m2, Group 3; . 26 kg/m2). The primary end point was all cause death at 1 year. Results Over the median follow-up of 12 months, the event of primary end point occurred more frequently in the Group 1 patients than in the Group 3 patients (primary endpoint: adjusted hazard ratio [aHR], 1.537; 95% confidence interval [CI] 1.177 to 2.007, p = 0.002). Especially, cardiac death played a major role in this effect (aHR, 1.548; 95% confidence interval [CI] 1.128 to 2.124, p = 0.007). Conclusions Higher BMI appeared to be good prognostic factor on 1-year all cause death after AMI. This result suggests that higher BMI or obesity might confer a protective advantage over the lifequality after AMI.

Original languageEnglish
Article numbere0217525
JournalPloS one
Volume14
Issue number6
DOIs
Publication statusPublished - 2019 Jun 1

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myocardial infarction
body mass index
Hazards
Body Mass Index
Myocardial Infarction
Health
death
confidence interval
Cause of Death
obesity
Obesity
Confidence Intervals
National Institutes of Health
National Institutes of Health (U.S.)
Korea
endpoints
Korean Peninsula
Registries
Mortality

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Kim, D. W., Her, S. H., Park, H. W., Park, M. W., Chang, K., Chung, W. S., ... Chae, J. K. (2019). Association between body mass index and 1-year outcome after acute myocardial infarction. PloS one, 14(6), [e0217525]. https://doi.org/10.1371/journal.pone.0217525

Association between body mass index and 1-year outcome after acute myocardial infarction. / Kim, Dae Won; Her, Sung Ho; Park, Ha Wook; Park, Mahn Won; Chang, Kiyuk; Chung, Wook Sung; Seung, Ki Bae; Ahn, Tae Hoon; Jeong, Myung Ho; Rha, Seung-Woon; Kim, Hyo Soo; Gwon, Hyeon Cheol; Seong, In Whan; Hwang, Kyung Kuk; Chae, Shung Chull; Kim, Kwon Bae; Kim, Young Jo; Cha, Kwang Soo; Oh, Seok Kyu; Chae, Jei Keon.

In: PloS one, Vol. 14, No. 6, e0217525, 01.06.2019.

Research output: Contribution to journalArticle

Kim, DW, Her, SH, Park, HW, Park, MW, Chang, K, Chung, WS, Seung, KB, Ahn, TH, Jeong, MH, Rha, S-W, Kim, HS, Gwon, HC, Seong, IW, Hwang, KK, Chae, SC, Kim, KB, Kim, YJ, Cha, KS, Oh, SK & Chae, JK 2019, 'Association between body mass index and 1-year outcome after acute myocardial infarction', PloS one, vol. 14, no. 6, e0217525. https://doi.org/10.1371/journal.pone.0217525
Kim, Dae Won ; Her, Sung Ho ; Park, Ha Wook ; Park, Mahn Won ; Chang, Kiyuk ; Chung, Wook Sung ; Seung, Ki Bae ; Ahn, Tae Hoon ; Jeong, Myung Ho ; Rha, Seung-Woon ; Kim, Hyo Soo ; Gwon, Hyeon Cheol ; Seong, In Whan ; Hwang, Kyung Kuk ; Chae, Shung Chull ; Kim, Kwon Bae ; Kim, Young Jo ; Cha, Kwang Soo ; Oh, Seok Kyu ; Chae, Jei Keon. / Association between body mass index and 1-year outcome after acute myocardial infarction. In: PloS one. 2019 ; Vol. 14, No. 6.
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abstract = "Objectives Beneficial effects of overweight and obesity on mortality after acute myocardial infarction (AMI) have been described as {"}Body Mass Index (BMI) paradox{"}. However, the effects of BMI is still on debate. We analyzed the association between BMI and 1-year clinical outcomes after AMI. Methods Among 13,104 AMI patients registered in Korea Acute Myocardial Infarction Registry- National Institute of Health (KAMIR-NIH) between November 2011 and December 2015, 10,568 patients who eligible for this study were classified into 3 groups according to BMI (Group 1; < 22 kg/m2, 22 . Group 2 < 26 kg/m2, Group 3; . 26 kg/m2). The primary end point was all cause death at 1 year. Results Over the median follow-up of 12 months, the event of primary end point occurred more frequently in the Group 1 patients than in the Group 3 patients (primary endpoint: adjusted hazard ratio [aHR], 1.537; 95{\%} confidence interval [CI] 1.177 to 2.007, p = 0.002). Especially, cardiac death played a major role in this effect (aHR, 1.548; 95{\%} confidence interval [CI] 1.128 to 2.124, p = 0.007). Conclusions Higher BMI appeared to be good prognostic factor on 1-year all cause death after AMI. This result suggests that higher BMI or obesity might confer a protective advantage over the lifequality after AMI.",
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AU - Her, Sung Ho

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AU - Park, Mahn Won

AU - Chang, Kiyuk

AU - Chung, Wook Sung

AU - Seung, Ki Bae

AU - Ahn, Tae Hoon

AU - Jeong, Myung Ho

AU - Rha, Seung-Woon

AU - Kim, Hyo Soo

AU - Gwon, Hyeon Cheol

AU - Seong, In Whan

AU - Hwang, Kyung Kuk

AU - Chae, Shung Chull

AU - Kim, Kwon Bae

AU - Kim, Young Jo

AU - Cha, Kwang Soo

AU - Oh, Seok Kyu

AU - Chae, Jei Keon

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N2 - Objectives Beneficial effects of overweight and obesity on mortality after acute myocardial infarction (AMI) have been described as "Body Mass Index (BMI) paradox". However, the effects of BMI is still on debate. We analyzed the association between BMI and 1-year clinical outcomes after AMI. Methods Among 13,104 AMI patients registered in Korea Acute Myocardial Infarction Registry- National Institute of Health (KAMIR-NIH) between November 2011 and December 2015, 10,568 patients who eligible for this study were classified into 3 groups according to BMI (Group 1; < 22 kg/m2, 22 . Group 2 < 26 kg/m2, Group 3; . 26 kg/m2). The primary end point was all cause death at 1 year. Results Over the median follow-up of 12 months, the event of primary end point occurred more frequently in the Group 1 patients than in the Group 3 patients (primary endpoint: adjusted hazard ratio [aHR], 1.537; 95% confidence interval [CI] 1.177 to 2.007, p = 0.002). Especially, cardiac death played a major role in this effect (aHR, 1.548; 95% confidence interval [CI] 1.128 to 2.124, p = 0.007). Conclusions Higher BMI appeared to be good prognostic factor on 1-year all cause death after AMI. This result suggests that higher BMI or obesity might confer a protective advantage over the lifequality after AMI.

AB - Objectives Beneficial effects of overweight and obesity on mortality after acute myocardial infarction (AMI) have been described as "Body Mass Index (BMI) paradox". However, the effects of BMI is still on debate. We analyzed the association between BMI and 1-year clinical outcomes after AMI. Methods Among 13,104 AMI patients registered in Korea Acute Myocardial Infarction Registry- National Institute of Health (KAMIR-NIH) between November 2011 and December 2015, 10,568 patients who eligible for this study were classified into 3 groups according to BMI (Group 1; < 22 kg/m2, 22 . Group 2 < 26 kg/m2, Group 3; . 26 kg/m2). The primary end point was all cause death at 1 year. Results Over the median follow-up of 12 months, the event of primary end point occurred more frequently in the Group 1 patients than in the Group 3 patients (primary endpoint: adjusted hazard ratio [aHR], 1.537; 95% confidence interval [CI] 1.177 to 2.007, p = 0.002). Especially, cardiac death played a major role in this effect (aHR, 1.548; 95% confidence interval [CI] 1.128 to 2.124, p = 0.007). Conclusions Higher BMI appeared to be good prognostic factor on 1-year all cause death after AMI. This result suggests that higher BMI or obesity might confer a protective advantage over the lifequality after AMI.

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