Association between C-reactive protein and QTc interval in middle-aged men and women

Eunhee Kim, SoonJae Joo, Jinyoung Kim, Jeong Cheon Ahn, Je Hyeong Kim, Kuchan Kimm, Chol Shin

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: Both of prolonged QT interval and elevated C-reactive protein (CRP) levels are known to be risk factors of cardiovascular disease. To our knowledge, few studies have reported the direct relationship between CRP levels and the QT interval in middle-aged population. The objective of the present study was to examine the association of CRP level with QT interval. Methods and results: A total of 2471 men and 2287 women from the Korea n Health and Genome study underwent physical examination and completed a questionnaire. A 12-lead electrocardiogram (ECG) recording was obtained from each subject. Subjects who were taking statins, non-steroidal anti-inflammatory drugs (NSAID) and postmenopausal hormone replacement therapy, which are known to have an effect on CRP levels, were excluded. Geometric means of CRP levels were compared among three groups, which were classified by heart rate-corrected QT (QTc) interval: prolonged (≥440 msec in men and ≥450 msec in women), borderline (420-439 msec in men and 430-449 msec in women) and normal (<420 msec in men and <430 msec in women) groups. The means of CRP level in women, though over normal range, increased significantly as QTc interval was longer, independent of confounding factors, while those of men were on the borderline of significance. However, compared to normal range of QTc interval, prolonged QTc interval was associated with elevated CRP level, defined as more than 95 percentile of CRP, in men and women, respectively. Conclusions: Prolonged QTc interval in middle-aged men and women is associated with the elevated CRP, independent of confounding factors.

Original languageEnglish
Pages (from-to)653-659
Number of pages7
JournalEuropean Journal of Epidemiology
Volume21
Issue number9
DOIs
Publication statusPublished - 2006 Sep 1

Fingerprint

C-Reactive Protein
Reference Values
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Estrogen Replacement Therapy
Korea
Physical Examination
Electrocardiography
Anti-Inflammatory Agents
Cardiovascular Diseases
Heart Rate
Genome
Health
Pharmaceutical Preparations
Population

Keywords

  • C-reactive protein
  • Epidemiology
  • QT interval

ASJC Scopus subject areas

  • Epidemiology

Cite this

Association between C-reactive protein and QTc interval in middle-aged men and women. / Kim, Eunhee; Joo, SoonJae; Kim, Jinyoung; Ahn, Jeong Cheon; Kim, Je Hyeong; Kimm, Kuchan; Shin, Chol.

In: European Journal of Epidemiology, Vol. 21, No. 9, 01.09.2006, p. 653-659.

Research output: Contribution to journalArticle

@article{a24ab3f4cbbf48e291d54acba6863501,
title = "Association between C-reactive protein and QTc interval in middle-aged men and women",
abstract = "Background: Both of prolonged QT interval and elevated C-reactive protein (CRP) levels are known to be risk factors of cardiovascular disease. To our knowledge, few studies have reported the direct relationship between CRP levels and the QT interval in middle-aged population. The objective of the present study was to examine the association of CRP level with QT interval. Methods and results: A total of 2471 men and 2287 women from the Korea n Health and Genome study underwent physical examination and completed a questionnaire. A 12-lead electrocardiogram (ECG) recording was obtained from each subject. Subjects who were taking statins, non-steroidal anti-inflammatory drugs (NSAID) and postmenopausal hormone replacement therapy, which are known to have an effect on CRP levels, were excluded. Geometric means of CRP levels were compared among three groups, which were classified by heart rate-corrected QT (QTc) interval: prolonged (≥440 msec in men and ≥450 msec in women), borderline (420-439 msec in men and 430-449 msec in women) and normal (<420 msec in men and <430 msec in women) groups. The means of CRP level in women, though over normal range, increased significantly as QTc interval was longer, independent of confounding factors, while those of men were on the borderline of significance. However, compared to normal range of QTc interval, prolonged QTc interval was associated with elevated CRP level, defined as more than 95 percentile of CRP, in men and women, respectively. Conclusions: Prolonged QTc interval in middle-aged men and women is associated with the elevated CRP, independent of confounding factors.",
keywords = "C-reactive protein, Epidemiology, QT interval",
author = "Eunhee Kim and SoonJae Joo and Jinyoung Kim and Ahn, {Jeong Cheon} and Kim, {Je Hyeong} and Kuchan Kimm and Chol Shin",
year = "2006",
month = "9",
day = "1",
doi = "10.1007/s10654-006-9034-9",
language = "English",
volume = "21",
pages = "653--659",
journal = "European Journal of Epidemiology",
issn = "0393-2990",
publisher = "Springer Netherlands",
number = "9",

}

TY - JOUR

T1 - Association between C-reactive protein and QTc interval in middle-aged men and women

AU - Kim, Eunhee

AU - Joo, SoonJae

AU - Kim, Jinyoung

AU - Ahn, Jeong Cheon

AU - Kim, Je Hyeong

AU - Kimm, Kuchan

AU - Shin, Chol

PY - 2006/9/1

Y1 - 2006/9/1

N2 - Background: Both of prolonged QT interval and elevated C-reactive protein (CRP) levels are known to be risk factors of cardiovascular disease. To our knowledge, few studies have reported the direct relationship between CRP levels and the QT interval in middle-aged population. The objective of the present study was to examine the association of CRP level with QT interval. Methods and results: A total of 2471 men and 2287 women from the Korea n Health and Genome study underwent physical examination and completed a questionnaire. A 12-lead electrocardiogram (ECG) recording was obtained from each subject. Subjects who were taking statins, non-steroidal anti-inflammatory drugs (NSAID) and postmenopausal hormone replacement therapy, which are known to have an effect on CRP levels, were excluded. Geometric means of CRP levels were compared among three groups, which were classified by heart rate-corrected QT (QTc) interval: prolonged (≥440 msec in men and ≥450 msec in women), borderline (420-439 msec in men and 430-449 msec in women) and normal (<420 msec in men and <430 msec in women) groups. The means of CRP level in women, though over normal range, increased significantly as QTc interval was longer, independent of confounding factors, while those of men were on the borderline of significance. However, compared to normal range of QTc interval, prolonged QTc interval was associated with elevated CRP level, defined as more than 95 percentile of CRP, in men and women, respectively. Conclusions: Prolonged QTc interval in middle-aged men and women is associated with the elevated CRP, independent of confounding factors.

AB - Background: Both of prolonged QT interval and elevated C-reactive protein (CRP) levels are known to be risk factors of cardiovascular disease. To our knowledge, few studies have reported the direct relationship between CRP levels and the QT interval in middle-aged population. The objective of the present study was to examine the association of CRP level with QT interval. Methods and results: A total of 2471 men and 2287 women from the Korea n Health and Genome study underwent physical examination and completed a questionnaire. A 12-lead electrocardiogram (ECG) recording was obtained from each subject. Subjects who were taking statins, non-steroidal anti-inflammatory drugs (NSAID) and postmenopausal hormone replacement therapy, which are known to have an effect on CRP levels, were excluded. Geometric means of CRP levels were compared among three groups, which were classified by heart rate-corrected QT (QTc) interval: prolonged (≥440 msec in men and ≥450 msec in women), borderline (420-439 msec in men and 430-449 msec in women) and normal (<420 msec in men and <430 msec in women) groups. The means of CRP level in women, though over normal range, increased significantly as QTc interval was longer, independent of confounding factors, while those of men were on the borderline of significance. However, compared to normal range of QTc interval, prolonged QTc interval was associated with elevated CRP level, defined as more than 95 percentile of CRP, in men and women, respectively. Conclusions: Prolonged QTc interval in middle-aged men and women is associated with the elevated CRP, independent of confounding factors.

KW - C-reactive protein

KW - Epidemiology

KW - QT interval

UR - http://www.scopus.com/inward/record.url?scp=33750928381&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750928381&partnerID=8YFLogxK

U2 - 10.1007/s10654-006-9034-9

DO - 10.1007/s10654-006-9034-9

M3 - Article

C2 - 17072542

AN - SCOPUS:33750928381

VL - 21

SP - 653

EP - 659

JO - European Journal of Epidemiology

JF - European Journal of Epidemiology

SN - 0393-2990

IS - 9

ER -