Association between cord blood 25-hydroxy-vitamin D concentrations and respiratory tract infections in the first 6 months of age in a korean population: A birth cohort study (COCOA)

Youn Ho Shin, Jinho Yu, Kyung Won Kim, Kangmo Ahn, Seo Ah Hong, Eun Lee, Song I. Yang, Young Ho Jung, Hyung Young Kim, Ju Hee Seo, Ji Won Kwon, Byoung Ju Kim, Hyo Bin Kim, Jung Yeon Shim, Woo Kyung Kim, Dae-Jin Song, So Yeon Lee, Soo Young Lee, Gwang Cheon Jang, Dong In SuhHyun Jong Yang, Bong Sung Kim, Suk Joo Choi, Soo Young Oh, Ja Young Kwon, Kyung Ju Lee, Hee Jin Park, Pil Ryang Lee, Hye Sung Won, Soo Jong Hong

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Purpose: Previous studies suggest that the concentration of 25-hydroxyvitamin D [25(OH)D] in cord blood may show an inverse association with respiratory tract infections (RTI) during childhood. The aim of the present study was to examine the influence of 25(OH)D concentrations in cord blood on infant RTI in a Korean birth cohort. Methods: The levels of 25(OH)D in cord blood obtained from 525 Korean newborns in the prospective COhort for Childhood Origin of Asthma and allergic diseases were examined. The primary outcome variable of interest was the prevalence of RTI at 6-month follow-up, as diagnosed by pediatricians and pediatric allergy and pulmonology specialists. RTI included acute nasopharyngitis, rhinosinusitis, otitis media, croup, tracheobronchitis, bronchiolitis, and pneumonia. Results: The median concentration of 25(OH)D in cord blood was 32.0 nmol/L (interquartile range, 21.43 to 53.18). One hundred and eighty neonates (34.3%) showed 25(OH)D concentrations less than 25.0 nmol/L, 292 (55.6%) showed 25(OH)D concentrations of 25.0-74.9 nmol/L, and 53 (10.1%) showed concentrations of ≥75.0 nmol/L. Adjusting for the season of birth, multivitamin intake during pregnancy, and exposure to passive smoking during pregnancy, 25(OH)D concentrations showed an inverse association with the risk of acquiring acute nasopharyngitis by 6 months of age (P for trend= 0.0004). Conclusion: The results show that 89.9% of healthy newborns in Korea are born with vitamin D insufficiency or deficiency (34.3% and 55.6%, respectively). Cord blood vitamin D deficiency in healthy neonates is associated with an increased risk of acute nasopharyngitis by 6 months of age. More time spent outdoors and more intensified vitamin D supplementation for pregnant women may be needed to prevent the onset of acute nasopharyngitis in infants.

Original languageEnglish
Pages (from-to)439-445
Number of pages7
JournalKorean Journal of Pediatrics
Volume56
Issue number10
DOIs
Publication statusPublished - 2013 Jan 1

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Nasopharyngitis
Fetal Blood
Vitamin D
Respiratory Tract Infections
Cohort Studies
Parturition
Newborn Infant
Population
Croup
Avitaminosis
Pregnancy
Pulmonary Medicine
Tobacco Smoke Pollution
Bronchiolitis
Vitamin D Deficiency
Otitis Media
Korea
Pregnant Women
Pneumonia
Hypersensitivity

Keywords

  • Cohort studies
  • Infant
  • Respiratory tract infections
  • Umbilical cord blood
  • Vitamin D

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pediatrics

Cite this

Association between cord blood 25-hydroxy-vitamin D concentrations and respiratory tract infections in the first 6 months of age in a korean population : A birth cohort study (COCOA). / Shin, Youn Ho; Yu, Jinho; Kim, Kyung Won; Ahn, Kangmo; Hong, Seo Ah; Lee, Eun; Yang, Song I.; Jung, Young Ho; Kim, Hyung Young; Seo, Ju Hee; Kwon, Ji Won; Kim, Byoung Ju; Kim, Hyo Bin; Shim, Jung Yeon; Kim, Woo Kyung; Song, Dae-Jin; Lee, So Yeon; Lee, Soo Young; Jang, Gwang Cheon; Suh, Dong In; Yang, Hyun Jong; Kim, Bong Sung; Choi, Suk Joo; Oh, Soo Young; Kwon, Ja Young; Lee, Kyung Ju; Park, Hee Jin; Lee, Pil Ryang; Won, Hye Sung; Hong, Soo Jong.

In: Korean Journal of Pediatrics, Vol. 56, No. 10, 01.01.2013, p. 439-445.

Research output: Contribution to journalArticle

Shin, YH, Yu, J, Kim, KW, Ahn, K, Hong, SA, Lee, E, Yang, SI, Jung, YH, Kim, HY, Seo, JH, Kwon, JW, Kim, BJ, Kim, HB, Shim, JY, Kim, WK, Song, D-J, Lee, SY, Lee, SY, Jang, GC, Suh, DI, Yang, HJ, Kim, BS, Choi, SJ, Oh, SY, Kwon, JY, Lee, KJ, Park, HJ, Lee, PR, Won, HS & Hong, SJ 2013, 'Association between cord blood 25-hydroxy-vitamin D concentrations and respiratory tract infections in the first 6 months of age in a korean population: A birth cohort study (COCOA)', Korean Journal of Pediatrics, vol. 56, no. 10, pp. 439-445. https://doi.org/10.3345/kjp.2013.56.10.439
Shin, Youn Ho ; Yu, Jinho ; Kim, Kyung Won ; Ahn, Kangmo ; Hong, Seo Ah ; Lee, Eun ; Yang, Song I. ; Jung, Young Ho ; Kim, Hyung Young ; Seo, Ju Hee ; Kwon, Ji Won ; Kim, Byoung Ju ; Kim, Hyo Bin ; Shim, Jung Yeon ; Kim, Woo Kyung ; Song, Dae-Jin ; Lee, So Yeon ; Lee, Soo Young ; Jang, Gwang Cheon ; Suh, Dong In ; Yang, Hyun Jong ; Kim, Bong Sung ; Choi, Suk Joo ; Oh, Soo Young ; Kwon, Ja Young ; Lee, Kyung Ju ; Park, Hee Jin ; Lee, Pil Ryang ; Won, Hye Sung ; Hong, Soo Jong. / Association between cord blood 25-hydroxy-vitamin D concentrations and respiratory tract infections in the first 6 months of age in a korean population : A birth cohort study (COCOA). In: Korean Journal of Pediatrics. 2013 ; Vol. 56, No. 10. pp. 439-445.
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abstract = "Purpose: Previous studies suggest that the concentration of 25-hydroxyvitamin D [25(OH)D] in cord blood may show an inverse association with respiratory tract infections (RTI) during childhood. The aim of the present study was to examine the influence of 25(OH)D concentrations in cord blood on infant RTI in a Korean birth cohort. Methods: The levels of 25(OH)D in cord blood obtained from 525 Korean newborns in the prospective COhort for Childhood Origin of Asthma and allergic diseases were examined. The primary outcome variable of interest was the prevalence of RTI at 6-month follow-up, as diagnosed by pediatricians and pediatric allergy and pulmonology specialists. RTI included acute nasopharyngitis, rhinosinusitis, otitis media, croup, tracheobronchitis, bronchiolitis, and pneumonia. Results: The median concentration of 25(OH)D in cord blood was 32.0 nmol/L (interquartile range, 21.43 to 53.18). One hundred and eighty neonates (34.3{\%}) showed 25(OH)D concentrations less than 25.0 nmol/L, 292 (55.6{\%}) showed 25(OH)D concentrations of 25.0-74.9 nmol/L, and 53 (10.1{\%}) showed concentrations of ≥75.0 nmol/L. Adjusting for the season of birth, multivitamin intake during pregnancy, and exposure to passive smoking during pregnancy, 25(OH)D concentrations showed an inverse association with the risk of acquiring acute nasopharyngitis by 6 months of age (P for trend= 0.0004). Conclusion: The results show that 89.9{\%} of healthy newborns in Korea are born with vitamin D insufficiency or deficiency (34.3{\%} and 55.6{\%}, respectively). Cord blood vitamin D deficiency in healthy neonates is associated with an increased risk of acute nasopharyngitis by 6 months of age. More time spent outdoors and more intensified vitamin D supplementation for pregnant women may be needed to prevent the onset of acute nasopharyngitis in infants.",
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author = "Shin, {Youn Ho} and Jinho Yu and Kim, {Kyung Won} and Kangmo Ahn and Hong, {Seo Ah} and Eun Lee and Yang, {Song I.} and Jung, {Young Ho} and Kim, {Hyung Young} and Seo, {Ju Hee} and Kwon, {Ji Won} and Kim, {Byoung Ju} and Kim, {Hyo Bin} and Shim, {Jung Yeon} and Kim, {Woo Kyung} and Dae-Jin Song and Lee, {So Yeon} and Lee, {Soo Young} and Jang, {Gwang Cheon} and Suh, {Dong In} and Yang, {Hyun Jong} and Kim, {Bong Sung} and Choi, {Suk Joo} and Oh, {Soo Young} and Kwon, {Ja Young} and Lee, {Kyung Ju} and Park, {Hee Jin} and Lee, {Pil Ryang} and Won, {Hye Sung} and Hong, {Soo Jong}",
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TY - JOUR

T1 - Association between cord blood 25-hydroxy-vitamin D concentrations and respiratory tract infections in the first 6 months of age in a korean population

T2 - A birth cohort study (COCOA)

AU - Shin, Youn Ho

AU - Yu, Jinho

AU - Kim, Kyung Won

AU - Ahn, Kangmo

AU - Hong, Seo Ah

AU - Lee, Eun

AU - Yang, Song I.

AU - Jung, Young Ho

AU - Kim, Hyung Young

AU - Seo, Ju Hee

AU - Kwon, Ji Won

AU - Kim, Byoung Ju

AU - Kim, Hyo Bin

AU - Shim, Jung Yeon

AU - Kim, Woo Kyung

AU - Song, Dae-Jin

AU - Lee, So Yeon

AU - Lee, Soo Young

AU - Jang, Gwang Cheon

AU - Suh, Dong In

AU - Yang, Hyun Jong

AU - Kim, Bong Sung

AU - Choi, Suk Joo

AU - Oh, Soo Young

AU - Kwon, Ja Young

AU - Lee, Kyung Ju

AU - Park, Hee Jin

AU - Lee, Pil Ryang

AU - Won, Hye Sung

AU - Hong, Soo Jong

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Purpose: Previous studies suggest that the concentration of 25-hydroxyvitamin D [25(OH)D] in cord blood may show an inverse association with respiratory tract infections (RTI) during childhood. The aim of the present study was to examine the influence of 25(OH)D concentrations in cord blood on infant RTI in a Korean birth cohort. Methods: The levels of 25(OH)D in cord blood obtained from 525 Korean newborns in the prospective COhort for Childhood Origin of Asthma and allergic diseases were examined. The primary outcome variable of interest was the prevalence of RTI at 6-month follow-up, as diagnosed by pediatricians and pediatric allergy and pulmonology specialists. RTI included acute nasopharyngitis, rhinosinusitis, otitis media, croup, tracheobronchitis, bronchiolitis, and pneumonia. Results: The median concentration of 25(OH)D in cord blood was 32.0 nmol/L (interquartile range, 21.43 to 53.18). One hundred and eighty neonates (34.3%) showed 25(OH)D concentrations less than 25.0 nmol/L, 292 (55.6%) showed 25(OH)D concentrations of 25.0-74.9 nmol/L, and 53 (10.1%) showed concentrations of ≥75.0 nmol/L. Adjusting for the season of birth, multivitamin intake during pregnancy, and exposure to passive smoking during pregnancy, 25(OH)D concentrations showed an inverse association with the risk of acquiring acute nasopharyngitis by 6 months of age (P for trend= 0.0004). Conclusion: The results show that 89.9% of healthy newborns in Korea are born with vitamin D insufficiency or deficiency (34.3% and 55.6%, respectively). Cord blood vitamin D deficiency in healthy neonates is associated with an increased risk of acute nasopharyngitis by 6 months of age. More time spent outdoors and more intensified vitamin D supplementation for pregnant women may be needed to prevent the onset of acute nasopharyngitis in infants.

AB - Purpose: Previous studies suggest that the concentration of 25-hydroxyvitamin D [25(OH)D] in cord blood may show an inverse association with respiratory tract infections (RTI) during childhood. The aim of the present study was to examine the influence of 25(OH)D concentrations in cord blood on infant RTI in a Korean birth cohort. Methods: The levels of 25(OH)D in cord blood obtained from 525 Korean newborns in the prospective COhort for Childhood Origin of Asthma and allergic diseases were examined. The primary outcome variable of interest was the prevalence of RTI at 6-month follow-up, as diagnosed by pediatricians and pediatric allergy and pulmonology specialists. RTI included acute nasopharyngitis, rhinosinusitis, otitis media, croup, tracheobronchitis, bronchiolitis, and pneumonia. Results: The median concentration of 25(OH)D in cord blood was 32.0 nmol/L (interquartile range, 21.43 to 53.18). One hundred and eighty neonates (34.3%) showed 25(OH)D concentrations less than 25.0 nmol/L, 292 (55.6%) showed 25(OH)D concentrations of 25.0-74.9 nmol/L, and 53 (10.1%) showed concentrations of ≥75.0 nmol/L. Adjusting for the season of birth, multivitamin intake during pregnancy, and exposure to passive smoking during pregnancy, 25(OH)D concentrations showed an inverse association with the risk of acquiring acute nasopharyngitis by 6 months of age (P for trend= 0.0004). Conclusion: The results show that 89.9% of healthy newborns in Korea are born with vitamin D insufficiency or deficiency (34.3% and 55.6%, respectively). Cord blood vitamin D deficiency in healthy neonates is associated with an increased risk of acute nasopharyngitis by 6 months of age. More time spent outdoors and more intensified vitamin D supplementation for pregnant women may be needed to prevent the onset of acute nasopharyngitis in infants.

KW - Cohort studies

KW - Infant

KW - Respiratory tract infections

KW - Umbilical cord blood

KW - Vitamin D

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