Association between FCGR3B copy number variations and susceptibility to autoimmune diseases: a meta-analysis

Young Ho Lee, Sang Cheol Bae, Young Ho Seo, Jae Hoon Kim, Sungjae Choi, Jong Dae Ji, Gwan Gyu Song

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: This study determined whether FCGR3B copy number variations (CNVs) were associated with susceptibility to autoimmune diseases. Methods: A meta-analysis was conducted to determine the association between FCGR3B CNVs and susceptibility to autoimmune diseases by comparing low FCGR3B CN (<2 to ≥2) and high FCGR3B CN (>2 to ≤2). Results: In all, 28 comparative studies from 15 reports involving 12,160 patients and 11,103 controls were included in this meta-analysis. The meta-analysis showed a significant association between low FCGR3B CN and autoimmune diseases (OR = 1.496, 95 % CI = 1.301–1.716, p = 1.0 × 10−9). Subgroup analysis according to ethnicity indicated an association between low FCGR3B CN and autoimmune diseases in Caucasians (OR = 1.482, 95 % CI = 1.219–1.801, p = 7.7 × 10−6) and Asians (OR = 1.498, 95 % CI = 1.306–1.717, p = 1.0 × 10−9). Meta-analysis according to the type of autoimmune disease indicated a significant association of low FCGR3B CN with systemic lupus erythematosus (SLE; OR = 1.797, 95 % CI = 1.562–2.068, p < 1.0 × 10−9), primary Sjogren’s syndrome (pSS; OR = 2.263, 95 % CI = 1.316–3.892, p = 0.003), and Wegener’s granulomatosis (WG; OR = 1.973, 95 % CI = 1.178–3.302, p = 0.010), but not with rheumatoid arthritis (RA; OR = 1.333, 95 % CI = 0.947–1.877, p = 0.099). However, the meta-analysis showed no association between high FCGR3B CN and SLE, RA, pSS, and WG. Conclusions: Thus, the results of this meta-analysis indicated that low FCGR3B CN increased susceptibility to autoimmune diseases, especially SLE, pSS, and WG.

Original languageEnglish
Pages (from-to)983-991
Number of pages9
JournalInflammation Research
Volume64
Issue number12
DOIs
Publication statusPublished - 2015 Sep 25

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Autoimmune Diseases
Meta-Analysis
Granulomatosis with Polyangiitis
Sjogren's Syndrome
Systemic Lupus Erythematosus
Rheumatoid Arthritis

Keywords

  • Autoimmune diseases
  • Copy number variation
  • FCGR3B
  • Meta-analysis

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Cite this

Association between FCGR3B copy number variations and susceptibility to autoimmune diseases : a meta-analysis. / Lee, Young Ho; Bae, Sang Cheol; Seo, Young Ho; Kim, Jae Hoon; Choi, Sungjae; Ji, Jong Dae; Song, Gwan Gyu.

In: Inflammation Research, Vol. 64, No. 12, 25.09.2015, p. 983-991.

Research output: Contribution to journalArticle

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abstract = "Objective: This study determined whether FCGR3B copy number variations (CNVs) were associated with susceptibility to autoimmune diseases. Methods: A meta-analysis was conducted to determine the association between FCGR3B CNVs and susceptibility to autoimmune diseases by comparing low FCGR3B CN (<2 to ≥2) and high FCGR3B CN (>2 to ≤2). Results: In all, 28 comparative studies from 15 reports involving 12,160 patients and 11,103 controls were included in this meta-analysis. The meta-analysis showed a significant association between low FCGR3B CN and autoimmune diseases (OR = 1.496, 95 {\%} CI = 1.301–1.716, p = 1.0 × 10−9). Subgroup analysis according to ethnicity indicated an association between low FCGR3B CN and autoimmune diseases in Caucasians (OR = 1.482, 95 {\%} CI = 1.219–1.801, p = 7.7 × 10−6) and Asians (OR = 1.498, 95 {\%} CI = 1.306–1.717, p = 1.0 × 10−9). Meta-analysis according to the type of autoimmune disease indicated a significant association of low FCGR3B CN with systemic lupus erythematosus (SLE; OR = 1.797, 95 {\%} CI = 1.562–2.068, p < 1.0 × 10−9), primary Sjogren’s syndrome (pSS; OR = 2.263, 95 {\%} CI = 1.316–3.892, p = 0.003), and Wegener’s granulomatosis (WG; OR = 1.973, 95 {\%} CI = 1.178–3.302, p = 0.010), but not with rheumatoid arthritis (RA; OR = 1.333, 95 {\%} CI = 0.947–1.877, p = 0.099). However, the meta-analysis showed no association between high FCGR3B CN and SLE, RA, pSS, and WG. Conclusions: Thus, the results of this meta-analysis indicated that low FCGR3B CN increased susceptibility to autoimmune diseases, especially SLE, pSS, and WG.",
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T1 - Association between FCGR3B copy number variations and susceptibility to autoimmune diseases

T2 - a meta-analysis

AU - Lee, Young Ho

AU - Bae, Sang Cheol

AU - Seo, Young Ho

AU - Kim, Jae Hoon

AU - Choi, Sungjae

AU - Ji, Jong Dae

AU - Song, Gwan Gyu

PY - 2015/9/25

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N2 - Objective: This study determined whether FCGR3B copy number variations (CNVs) were associated with susceptibility to autoimmune diseases. Methods: A meta-analysis was conducted to determine the association between FCGR3B CNVs and susceptibility to autoimmune diseases by comparing low FCGR3B CN (<2 to ≥2) and high FCGR3B CN (>2 to ≤2). Results: In all, 28 comparative studies from 15 reports involving 12,160 patients and 11,103 controls were included in this meta-analysis. The meta-analysis showed a significant association between low FCGR3B CN and autoimmune diseases (OR = 1.496, 95 % CI = 1.301–1.716, p = 1.0 × 10−9). Subgroup analysis according to ethnicity indicated an association between low FCGR3B CN and autoimmune diseases in Caucasians (OR = 1.482, 95 % CI = 1.219–1.801, p = 7.7 × 10−6) and Asians (OR = 1.498, 95 % CI = 1.306–1.717, p = 1.0 × 10−9). Meta-analysis according to the type of autoimmune disease indicated a significant association of low FCGR3B CN with systemic lupus erythematosus (SLE; OR = 1.797, 95 % CI = 1.562–2.068, p < 1.0 × 10−9), primary Sjogren’s syndrome (pSS; OR = 2.263, 95 % CI = 1.316–3.892, p = 0.003), and Wegener’s granulomatosis (WG; OR = 1.973, 95 % CI = 1.178–3.302, p = 0.010), but not with rheumatoid arthritis (RA; OR = 1.333, 95 % CI = 0.947–1.877, p = 0.099). However, the meta-analysis showed no association between high FCGR3B CN and SLE, RA, pSS, and WG. Conclusions: Thus, the results of this meta-analysis indicated that low FCGR3B CN increased susceptibility to autoimmune diseases, especially SLE, pSS, and WG.

AB - Objective: This study determined whether FCGR3B copy number variations (CNVs) were associated with susceptibility to autoimmune diseases. Methods: A meta-analysis was conducted to determine the association between FCGR3B CNVs and susceptibility to autoimmune diseases by comparing low FCGR3B CN (<2 to ≥2) and high FCGR3B CN (>2 to ≤2). Results: In all, 28 comparative studies from 15 reports involving 12,160 patients and 11,103 controls were included in this meta-analysis. The meta-analysis showed a significant association between low FCGR3B CN and autoimmune diseases (OR = 1.496, 95 % CI = 1.301–1.716, p = 1.0 × 10−9). Subgroup analysis according to ethnicity indicated an association between low FCGR3B CN and autoimmune diseases in Caucasians (OR = 1.482, 95 % CI = 1.219–1.801, p = 7.7 × 10−6) and Asians (OR = 1.498, 95 % CI = 1.306–1.717, p = 1.0 × 10−9). Meta-analysis according to the type of autoimmune disease indicated a significant association of low FCGR3B CN with systemic lupus erythematosus (SLE; OR = 1.797, 95 % CI = 1.562–2.068, p < 1.0 × 10−9), primary Sjogren’s syndrome (pSS; OR = 2.263, 95 % CI = 1.316–3.892, p = 0.003), and Wegener’s granulomatosis (WG; OR = 1.973, 95 % CI = 1.178–3.302, p = 0.010), but not with rheumatoid arthritis (RA; OR = 1.333, 95 % CI = 0.947–1.877, p = 0.099). However, the meta-analysis showed no association between high FCGR3B CN and SLE, RA, pSS, and WG. Conclusions: Thus, the results of this meta-analysis indicated that low FCGR3B CN increased susceptibility to autoimmune diseases, especially SLE, pSS, and WG.

KW - Autoimmune diseases

KW - Copy number variation

KW - FCGR3B

KW - Meta-analysis

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