Abstract
Objective: The aim of this study was to explore whether the FOXP3-3279 A/C polymorphism and (GT)n microsatellite polymorphisms are associated with susceptibility to autoimmune diseases. Methods: A meta-analysis was conducted on the associations between the FOXP3 -3279 A/C polymorphism and (GT)15 and (GT)16 polymorphisms and autoimmune diseases. Results: Twenty-two comparative studies with a total of 7962 patients and 7453 controls were included in the meta-analysis. Meta-analysis revealed an association between autoimmune disease and the FOXP3 -3279 AA + AC genotype (OR = 1.480, 95% CI = 1.263-1.614, p < 1.0 × 10-9), and stratification by ethnicity indicated a significant association between the FOXP3 -3279 AA + AC genotype and autoimmune diseases in Asians (OR = 1.416, 95% CI = 1.225-1.637, p = 2.5 × 10-7) and non-Caucasians (OR = 1.432, 95% CI = 1.245-1.647, p = 7.5 × 10-8). In addition, corrected p values for multiple testing remained significant. Meta-analysis revealed no association between autoimmune disease and the FOXP3 (GT)15 allele (OR = 1.051, 95% CI = 0.933-1.183, p = 0.413). Similarly, the FOXP3 (GT)16 allele showed no associations with autoimmune disease. Conclusions: This meta-analysis indicates that the FOXP3 -3279 A/C polymorphism is associated with susceptibility to autoimmune disease in Asians and non-Caucasians.
| Original language | English |
|---|---|
| Pages (from-to) | 445-452 |
| Number of pages | 8 |
| Journal | Autoimmunity |
| Volume | 48 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2015 Jan 1 |
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Keywords
- Autoimmune diseases
- FOXP3
- meta-analysis
- polymorphism
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
Association between FOXP3 polymorphisms and susceptibility to autoimmune diseases : A meta-analysis. / Lee, Min Gu; Bae, Sang Cheol; Lee, Young Ho.
In: Autoimmunity, Vol. 48, No. 7, 01.01.2015, p. 445-452.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association between FOXP3 polymorphisms and susceptibility to autoimmune diseases
T2 - A meta-analysis
AU - Lee, Min Gu
AU - Bae, Sang Cheol
AU - Lee, Young Ho
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Objective: The aim of this study was to explore whether the FOXP3-3279 A/C polymorphism and (GT)n microsatellite polymorphisms are associated with susceptibility to autoimmune diseases. Methods: A meta-analysis was conducted on the associations between the FOXP3 -3279 A/C polymorphism and (GT)15 and (GT)16 polymorphisms and autoimmune diseases. Results: Twenty-two comparative studies with a total of 7962 patients and 7453 controls were included in the meta-analysis. Meta-analysis revealed an association between autoimmune disease and the FOXP3 -3279 AA + AC genotype (OR = 1.480, 95% CI = 1.263-1.614, p < 1.0 × 10-9), and stratification by ethnicity indicated a significant association between the FOXP3 -3279 AA + AC genotype and autoimmune diseases in Asians (OR = 1.416, 95% CI = 1.225-1.637, p = 2.5 × 10-7) and non-Caucasians (OR = 1.432, 95% CI = 1.245-1.647, p = 7.5 × 10-8). In addition, corrected p values for multiple testing remained significant. Meta-analysis revealed no association between autoimmune disease and the FOXP3 (GT)15 allele (OR = 1.051, 95% CI = 0.933-1.183, p = 0.413). Similarly, the FOXP3 (GT)16 allele showed no associations with autoimmune disease. Conclusions: This meta-analysis indicates that the FOXP3 -3279 A/C polymorphism is associated with susceptibility to autoimmune disease in Asians and non-Caucasians.
AB - Objective: The aim of this study was to explore whether the FOXP3-3279 A/C polymorphism and (GT)n microsatellite polymorphisms are associated with susceptibility to autoimmune diseases. Methods: A meta-analysis was conducted on the associations between the FOXP3 -3279 A/C polymorphism and (GT)15 and (GT)16 polymorphisms and autoimmune diseases. Results: Twenty-two comparative studies with a total of 7962 patients and 7453 controls were included in the meta-analysis. Meta-analysis revealed an association between autoimmune disease and the FOXP3 -3279 AA + AC genotype (OR = 1.480, 95% CI = 1.263-1.614, p < 1.0 × 10-9), and stratification by ethnicity indicated a significant association between the FOXP3 -3279 AA + AC genotype and autoimmune diseases in Asians (OR = 1.416, 95% CI = 1.225-1.637, p = 2.5 × 10-7) and non-Caucasians (OR = 1.432, 95% CI = 1.245-1.647, p = 7.5 × 10-8). In addition, corrected p values for multiple testing remained significant. Meta-analysis revealed no association between autoimmune disease and the FOXP3 (GT)15 allele (OR = 1.051, 95% CI = 0.933-1.183, p = 0.413). Similarly, the FOXP3 (GT)16 allele showed no associations with autoimmune disease. Conclusions: This meta-analysis indicates that the FOXP3 -3279 A/C polymorphism is associated with susceptibility to autoimmune disease in Asians and non-Caucasians.
KW - Autoimmune diseases
KW - FOXP3
KW - meta-analysis
KW - polymorphism
UR - http://www.scopus.com/inward/record.url?scp=84946556301&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84946556301&partnerID=8YFLogxK
U2 - 10.3109/08916934.2015.1045582
DO - 10.3109/08916934.2015.1045582
M3 - Article
C2 - 25977253
AN - SCOPUS:84946556301
VL - 48
SP - 445
EP - 452
JO - Autoimmunity
JF - Autoimmunity
SN - 0891-6934
IS - 7
ER -