TY - JOUR
T1 - Association between functional cd24 polymorphisms and susceptibility to autoimmune diseases
T2 - A meta-analysis
AU - Lee, Young Ho
AU - Bae, S. C.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - This study aimed to explore whether the functional CD24 A57V and TG/del polymorphisms are associated with susceptibility to autoimmune diseases. A meta-analysis was conducted on the associations between the CD24 A57V and TG/del polymorphisms and autoimmune diseases using (1) allele contrast, and (2) the recessive, (3) dominant, and (4) co-dominant models. Twenty-six comparative studies with 7,507 patients and 8,803 controls were included in the meta-analysis. The meta-analysis revealed a significant association between autoimmune disease and the CD24 Val allele (OR = 1.285, 95% CI = 1.177-1.403, p = 1.0 × 10-9). Meta-analysis by autoimmune disease type showed a significant association between the CD24 Val allele and multiple sclerosis (MS) (OR = 1.420, 95% CI = 1.239-1.628, p = 4.7 × 10-8) and systemic lupus erythematous (SLE) (OR = 1.282, 95% CI = 1.081-1.521, p = 0.004), but not Crohn's disease (CD) (OR = 1.003, 95% CI = 0.826-1.218, p = 0.974). Meta-analysis of the CD24 Val/Val genotype showed an association with ulcerative colitis (OR = 1.778, 95% CI = 1.148-2.753, p = 0.010). In addition, meta-analysis by autoimmune disease type revealed a significant association between the CD24 TG-deletion allele and MS (OR = 0.596, 95% CI = 0.415-0.856, p = 0.005) and CD (OR = 1.594, 95% CI = 1.175-2.161, p = 0.003). This meta-analysis indicates that the functional CD24 A57V and TG/del polymorphisms are associated with susceptibility to multiple autoimmune diseases including SLE, MS, UC and CD.
AB - This study aimed to explore whether the functional CD24 A57V and TG/del polymorphisms are associated with susceptibility to autoimmune diseases. A meta-analysis was conducted on the associations between the CD24 A57V and TG/del polymorphisms and autoimmune diseases using (1) allele contrast, and (2) the recessive, (3) dominant, and (4) co-dominant models. Twenty-six comparative studies with 7,507 patients and 8,803 controls were included in the meta-analysis. The meta-analysis revealed a significant association between autoimmune disease and the CD24 Val allele (OR = 1.285, 95% CI = 1.177-1.403, p = 1.0 × 10-9). Meta-analysis by autoimmune disease type showed a significant association between the CD24 Val allele and multiple sclerosis (MS) (OR = 1.420, 95% CI = 1.239-1.628, p = 4.7 × 10-8) and systemic lupus erythematous (SLE) (OR = 1.282, 95% CI = 1.081-1.521, p = 0.004), but not Crohn's disease (CD) (OR = 1.003, 95% CI = 0.826-1.218, p = 0.974). Meta-analysis of the CD24 Val/Val genotype showed an association with ulcerative colitis (OR = 1.778, 95% CI = 1.148-2.753, p = 0.010). In addition, meta-analysis by autoimmune disease type revealed a significant association between the CD24 TG-deletion allele and MS (OR = 0.596, 95% CI = 0.415-0.856, p = 0.005) and CD (OR = 1.594, 95% CI = 1.175-2.161, p = 0.003). This meta-analysis indicates that the functional CD24 A57V and TG/del polymorphisms are associated with susceptibility to multiple autoimmune diseases including SLE, MS, UC and CD.
KW - Autoimmune diseases
KW - Cd24
KW - Meta-analysis
KW - Polymorphism
UR - http://www.scopus.com/inward/record.url?scp=84962170694&partnerID=8YFLogxK
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U2 - 10.14715/cmb/2015.61.8.16
DO - 10.14715/cmb/2015.61.8.16
M3 - Article
C2 - 26718436
AN - SCOPUS:84962170694
VL - 61
SP - 97
EP - 104
JO - Cellular and Molecular Biology
JF - Cellular and Molecular Biology
SN - 0145-5680
IS - 8
ER -