Association between functional cd24 polymorphisms and susceptibility to autoimmune diseases: A meta-analysis

Young Ho Lee, S. C. Bae

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

This study aimed to explore whether the functional CD24 A57V and TG/del polymorphisms are associated with susceptibility to autoimmune diseases. A meta-analysis was conducted on the associations between the CD24 A57V and TG/del polymorphisms and autoimmune diseases using (1) allele contrast, and (2) the recessive, (3) dominant, and (4) co-dominant models. Twenty-six comparative studies with 7,507 patients and 8,803 controls were included in the meta-analysis. The meta-analysis revealed a significant association between autoimmune disease and the CD24 Val allele (OR = 1.285, 95% CI = 1.177-1.403, p = 1.0 × 10-9). Meta-analysis by autoimmune disease type showed a significant association between the CD24 Val allele and multiple sclerosis (MS) (OR = 1.420, 95% CI = 1.239-1.628, p = 4.7 × 10-8) and systemic lupus erythematous (SLE) (OR = 1.282, 95% CI = 1.081-1.521, p = 0.004), but not Crohn's disease (CD) (OR = 1.003, 95% CI = 0.826-1.218, p = 0.974). Meta-analysis of the CD24 Val/Val genotype showed an association with ulcerative colitis (OR = 1.778, 95% CI = 1.148-2.753, p = 0.010). In addition, meta-analysis by autoimmune disease type revealed a significant association between the CD24 TG-deletion allele and MS (OR = 0.596, 95% CI = 0.415-0.856, p = 0.005) and CD (OR = 1.594, 95% CI = 1.175-2.161, p = 0.003). This meta-analysis indicates that the functional CD24 A57V and TG/del polymorphisms are associated with susceptibility to multiple autoimmune diseases including SLE, MS, UC and CD.

Original languageEnglish
Pages (from-to)97-104
Number of pages8
JournalCellular and Molecular Biology
Volume61
Issue number8
DOIs
Publication statusPublished - 2015 Jan 1

Fingerprint

Polymorphism
Autoimmune Diseases
Meta-Analysis
Alleles
Crohn Disease
Multiple Sclerosis
Ulcerative Colitis
Genotype

Keywords

  • Autoimmune diseases
  • Cd24
  • Meta-analysis
  • Polymorphism

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Association between functional cd24 polymorphisms and susceptibility to autoimmune diseases : A meta-analysis. / Lee, Young Ho; Bae, S. C.

In: Cellular and Molecular Biology, Vol. 61, No. 8, 01.01.2015, p. 97-104.

Research output: Contribution to journalArticle

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