Association between functional Fc receptor-like 3 (FCRL3) -169 C/T polymorphism and susceptibility to seropositive rheumatoid arthritis in Asians

A meta-analysis

Gwan Gyu Song, Sang Cheol Bae, Jae Hoon Kim, Young Ho Kim, Sungjae Choi, Jong Dae Ji, Young Ho Lee

Research output: Contribution to journalArticle

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Abstract

Objective: The aim of this study was to determine whether the functional Fc receptor like-3 (FCRL3) -169 C/T polymorphism confers susceptibility to rheumatoid arthritis (RA). Methods: A meta-analysis was conducted on the associations between the FCRL3 -169 C/T polymorphism and RA. Results: A total of 17 comparison studies including 11,170 patients and 11,142 controls were considered in the meta-analysis. The meta-analysis showed no association between RA and the FCRL3 -169 C allele in study subjects (OR = 1.046, 95% CI = 0.997-1.098, p= 0.068). Stratification by ethnicity indicated an association between the FCRL3 -169 C allele and RA in Asians (OR = 1.101, 95% CI = 1.035-1.174, p= 0.002), but not in Europeans. Stratification of patients according to the presence of rheumatoid factor (RF) revealed a different significant association between the C allele and RA in RF-positive and RF-negative RA patients. Stratification by ethnicity indicated an association between the FCRL3 -169 C allele and RF-positive RA in Asians (OR = 1.093, 95% CI = 1.004-1.189, p= 0.040), but not in Europeans. Conclusions: This meta-analysis demonstrates that the FCRL3 -169 C/T polymorphism may confer susceptibility to seropositive RA in Asians.

Original languageEnglish
Pages (from-to)1206-1213
Number of pages8
JournalHuman Immunology
Volume74
Issue number9
DOIs
Publication statusPublished - 2013 Sep 1

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Fc Receptors
Meta-Analysis
Rheumatoid Arthritis
Rheumatoid Factor
Alleles

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

@article{55b3860a3a0d4a39a686bd3bb3d4af32,
title = "Association between functional Fc receptor-like 3 (FCRL3) -169 C/T polymorphism and susceptibility to seropositive rheumatoid arthritis in Asians: A meta-analysis",
abstract = "Objective: The aim of this study was to determine whether the functional Fc receptor like-3 (FCRL3) -169 C/T polymorphism confers susceptibility to rheumatoid arthritis (RA). Methods: A meta-analysis was conducted on the associations between the FCRL3 -169 C/T polymorphism and RA. Results: A total of 17 comparison studies including 11,170 patients and 11,142 controls were considered in the meta-analysis. The meta-analysis showed no association between RA and the FCRL3 -169 C allele in study subjects (OR = 1.046, 95{\%} CI = 0.997-1.098, p= 0.068). Stratification by ethnicity indicated an association between the FCRL3 -169 C allele and RA in Asians (OR = 1.101, 95{\%} CI = 1.035-1.174, p= 0.002), but not in Europeans. Stratification of patients according to the presence of rheumatoid factor (RF) revealed a different significant association between the C allele and RA in RF-positive and RF-negative RA patients. Stratification by ethnicity indicated an association between the FCRL3 -169 C allele and RF-positive RA in Asians (OR = 1.093, 95{\%} CI = 1.004-1.189, p= 0.040), but not in Europeans. Conclusions: This meta-analysis demonstrates that the FCRL3 -169 C/T polymorphism may confer susceptibility to seropositive RA in Asians.",
author = "Song, {Gwan Gyu} and Bae, {Sang Cheol} and Kim, {Jae Hoon} and Kim, {Young Ho} and Sungjae Choi and Ji, {Jong Dae} and Lee, {Young Ho}",
year = "2013",
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T1 - Association between functional Fc receptor-like 3 (FCRL3) -169 C/T polymorphism and susceptibility to seropositive rheumatoid arthritis in Asians

T2 - A meta-analysis

AU - Song, Gwan Gyu

AU - Bae, Sang Cheol

AU - Kim, Jae Hoon

AU - Kim, Young Ho

AU - Choi, Sungjae

AU - Ji, Jong Dae

AU - Lee, Young Ho

PY - 2013/9/1

Y1 - 2013/9/1

N2 - Objective: The aim of this study was to determine whether the functional Fc receptor like-3 (FCRL3) -169 C/T polymorphism confers susceptibility to rheumatoid arthritis (RA). Methods: A meta-analysis was conducted on the associations between the FCRL3 -169 C/T polymorphism and RA. Results: A total of 17 comparison studies including 11,170 patients and 11,142 controls were considered in the meta-analysis. The meta-analysis showed no association between RA and the FCRL3 -169 C allele in study subjects (OR = 1.046, 95% CI = 0.997-1.098, p= 0.068). Stratification by ethnicity indicated an association between the FCRL3 -169 C allele and RA in Asians (OR = 1.101, 95% CI = 1.035-1.174, p= 0.002), but not in Europeans. Stratification of patients according to the presence of rheumatoid factor (RF) revealed a different significant association between the C allele and RA in RF-positive and RF-negative RA patients. Stratification by ethnicity indicated an association between the FCRL3 -169 C allele and RF-positive RA in Asians (OR = 1.093, 95% CI = 1.004-1.189, p= 0.040), but not in Europeans. Conclusions: This meta-analysis demonstrates that the FCRL3 -169 C/T polymorphism may confer susceptibility to seropositive RA in Asians.

AB - Objective: The aim of this study was to determine whether the functional Fc receptor like-3 (FCRL3) -169 C/T polymorphism confers susceptibility to rheumatoid arthritis (RA). Methods: A meta-analysis was conducted on the associations between the FCRL3 -169 C/T polymorphism and RA. Results: A total of 17 comparison studies including 11,170 patients and 11,142 controls were considered in the meta-analysis. The meta-analysis showed no association between RA and the FCRL3 -169 C allele in study subjects (OR = 1.046, 95% CI = 0.997-1.098, p= 0.068). Stratification by ethnicity indicated an association between the FCRL3 -169 C allele and RA in Asians (OR = 1.101, 95% CI = 1.035-1.174, p= 0.002), but not in Europeans. Stratification of patients according to the presence of rheumatoid factor (RF) revealed a different significant association between the C allele and RA in RF-positive and RF-negative RA patients. Stratification by ethnicity indicated an association between the FCRL3 -169 C allele and RF-positive RA in Asians (OR = 1.093, 95% CI = 1.004-1.189, p= 0.040), but not in Europeans. Conclusions: This meta-analysis demonstrates that the FCRL3 -169 C/T polymorphism may confer susceptibility to seropositive RA in Asians.

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