Association between glycogen synthase kinase-3β gene polymorphisms and major depression and suicidal behavior in a Korean population

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Abstract

Background: Glycogen synthase kinase (GSK)-3β plays a key role in the phosphorylation and regulation of metabolic enzymes and many transcription factors. Several lines of evidence implicate GSK-3β in the pathophysiology of mood disorders and susceptibility to suicidal behavior. In this study, we aimed to investigate the GSK-3β gene's association with major depressive disorder (MDD) and suicidal behavior. Methods: One hundred seventy suicidal depressed patients and 147 non-suicidal depressed patients who met DSM-IV criteria for MDD were recruited. One hundred sixty-four healthy volunteers recruited by local advertisement served as controls. Patients and normal controls were genotyped for GSK-3β - 1727A/T and - 50C/T. Haplotype trend regression (HTR) analysis was used for the evaluation of haplotype association. Results: The genotype distributions of - 1727A/T and - 50C/T were in agreement with Hardy-Weinberg equilibrium. The results showed that the alleles, genotypes, and haplotypes of the two SNPs do not differ between suicidal MDD subjects, non-suicidal MDD subjects, and normal controls. There was no difference in the haplotype frequency combination between the three groups. Conclusion: Our study suggests that two promoter polymorphisms of the GSK-3β gene may not be related to the pathogenesis of MDD and the risk of suicidal behavior in Korean depressive patients. Further studies with larger sample sizes and different populations are needed.

Original languageEnglish
Pages (from-to)331-334
Number of pages4
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume34
Issue number2
DOIs
Publication statusPublished - 2010 Mar 1

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Glycogen Synthase Kinase 3
Major Depressive Disorder
Haplotypes
Depression
Population
Genes
Genotype
Risk-Taking
Mood Disorders
Diagnostic and Statistical Manual of Mental Disorders
Sample Size
Single Nucleotide Polymorphism
Healthy Volunteers
Transcription Factors
Alleles
Regression Analysis
Phosphorylation
Enzymes

Keywords

  • Depression
  • GSK-3β
  • Polymorphism
  • Suicide

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

Cite this

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title = "Association between glycogen synthase kinase-3β gene polymorphisms and major depression and suicidal behavior in a Korean population",
abstract = "Background: Glycogen synthase kinase (GSK)-3β plays a key role in the phosphorylation and regulation of metabolic enzymes and many transcription factors. Several lines of evidence implicate GSK-3β in the pathophysiology of mood disorders and susceptibility to suicidal behavior. In this study, we aimed to investigate the GSK-3β gene's association with major depressive disorder (MDD) and suicidal behavior. Methods: One hundred seventy suicidal depressed patients and 147 non-suicidal depressed patients who met DSM-IV criteria for MDD were recruited. One hundred sixty-four healthy volunteers recruited by local advertisement served as controls. Patients and normal controls were genotyped for GSK-3β - 1727A/T and - 50C/T. Haplotype trend regression (HTR) analysis was used for the evaluation of haplotype association. Results: The genotype distributions of - 1727A/T and - 50C/T were in agreement with Hardy-Weinberg equilibrium. The results showed that the alleles, genotypes, and haplotypes of the two SNPs do not differ between suicidal MDD subjects, non-suicidal MDD subjects, and normal controls. There was no difference in the haplotype frequency combination between the three groups. Conclusion: Our study suggests that two promoter polymorphisms of the GSK-3β gene may not be related to the pathogenesis of MDD and the risk of suicidal behavior in Korean depressive patients. Further studies with larger sample sizes and different populations are needed.",
keywords = "Depression, GSK-3β, Polymorphism, Suicide",
author = "Ho-Kyoung Yoon and Kim, {Yong Ku}",
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T1 - Association between glycogen synthase kinase-3β gene polymorphisms and major depression and suicidal behavior in a Korean population

AU - Yoon, Ho-Kyoung

AU - Kim, Yong Ku

PY - 2010/3/1

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N2 - Background: Glycogen synthase kinase (GSK)-3β plays a key role in the phosphorylation and regulation of metabolic enzymes and many transcription factors. Several lines of evidence implicate GSK-3β in the pathophysiology of mood disorders and susceptibility to suicidal behavior. In this study, we aimed to investigate the GSK-3β gene's association with major depressive disorder (MDD) and suicidal behavior. Methods: One hundred seventy suicidal depressed patients and 147 non-suicidal depressed patients who met DSM-IV criteria for MDD were recruited. One hundred sixty-four healthy volunteers recruited by local advertisement served as controls. Patients and normal controls were genotyped for GSK-3β - 1727A/T and - 50C/T. Haplotype trend regression (HTR) analysis was used for the evaluation of haplotype association. Results: The genotype distributions of - 1727A/T and - 50C/T were in agreement with Hardy-Weinberg equilibrium. The results showed that the alleles, genotypes, and haplotypes of the two SNPs do not differ between suicidal MDD subjects, non-suicidal MDD subjects, and normal controls. There was no difference in the haplotype frequency combination between the three groups. Conclusion: Our study suggests that two promoter polymorphisms of the GSK-3β gene may not be related to the pathogenesis of MDD and the risk of suicidal behavior in Korean depressive patients. Further studies with larger sample sizes and different populations are needed.

AB - Background: Glycogen synthase kinase (GSK)-3β plays a key role in the phosphorylation and regulation of metabolic enzymes and many transcription factors. Several lines of evidence implicate GSK-3β in the pathophysiology of mood disorders and susceptibility to suicidal behavior. In this study, we aimed to investigate the GSK-3β gene's association with major depressive disorder (MDD) and suicidal behavior. Methods: One hundred seventy suicidal depressed patients and 147 non-suicidal depressed patients who met DSM-IV criteria for MDD were recruited. One hundred sixty-four healthy volunteers recruited by local advertisement served as controls. Patients and normal controls were genotyped for GSK-3β - 1727A/T and - 50C/T. Haplotype trend regression (HTR) analysis was used for the evaluation of haplotype association. Results: The genotype distributions of - 1727A/T and - 50C/T were in agreement with Hardy-Weinberg equilibrium. The results showed that the alleles, genotypes, and haplotypes of the two SNPs do not differ between suicidal MDD subjects, non-suicidal MDD subjects, and normal controls. There was no difference in the haplotype frequency combination between the three groups. Conclusion: Our study suggests that two promoter polymorphisms of the GSK-3β gene may not be related to the pathogenesis of MDD and the risk of suicidal behavior in Korean depressive patients. Further studies with larger sample sizes and different populations are needed.

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KW - Polymorphism

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