Association between IL-6 −174 G/C, IL-6 −634 G/C, and IFN-γ +874 A/T polymorphisms and susceptibility to recurrent pregnancy loss

a meta-analysis

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: The aim of this study was to determine whether interleukin-6 (IL-6) −174 G/C, IL-6 −634 G/C, and interferon-γ (IFN-γ) +874 A/T polymorphisms are associated with susceptibility to recurrent pregnancy loss (RPL). Methods: We conducted a literature search using PubMed and EMBASE databases and performed a meta-analysis using fixed- or random-effects models. Results: A total of 15 articles met the study inclusion criteria. When all study subjects were considered together, meta-analysis showed no association between RPL and the IL-6 −174 GG + GC genotype (odds ratio [OR] = 0.794, 95 % confidence interval [CI] = 0.542–1.163, p = 0.236). However, stratification of the data by ethnicity indicated an association between this genotype and RPL in non-Caucasians (OR = 0.528, 95 % CI = 0.302–0.925, p = 0.028), but not in Caucasian populations. Moreover, meta-analysis revealed an association between RPL and the IL-6 −634 GG + GC genotype in all study subjects (OR = 0.556, 95 % CI = 0.383–0.806, p = 0.002), while stratification by ethnicity revealed a negative association between this genotype and RPL in Asian (OR = 0.545, 95 % CI = 0.371–0.800, p = 0.002) but not Middle Eastern populations. Furthermore, a relationship between the IFN-γ +874 A allele and RPL was identified in non-Caucasians (OR = 1.403, 95 % CI = 1.133–1.734, p = 0.002), but not in Caucasians. Conclusions: This meta-analysis demonstrates that IL-6 −174 G/C, IL-6 −634 G/C, and IFN-γ +874 A/T polymorphisms are associated with susceptibility to RPL, particularly in non-Caucasians.

Original languageEnglish
Pages (from-to)1421-1427
Number of pages7
JournalJournal of Assisted Reproduction and Genetics
Volume32
Issue number9
DOIs
Publication statusPublished - 2015 Sep 4

Fingerprint

Interferons
Meta-Analysis
Interleukin-6
Pregnancy
Odds Ratio
Confidence Intervals
Genotype
PubMed
Population
Alleles
Databases

Keywords

  • IFN-γ
  • IL-6
  • Meta-analysis
  • Polymorphism
  • RPL

ASJC Scopus subject areas

  • Reproductive Medicine
  • Genetics
  • Obstetrics and Gynaecology
  • Developmental Biology
  • Genetics(clinical)

Cite this

@article{4881d7fc9ad84b8ebd53e3b6455c7844,
title = "Association between IL-6 −174 G/C, IL-6 −634 G/C, and IFN-γ +874 A/T polymorphisms and susceptibility to recurrent pregnancy loss: a meta-analysis",
abstract = "Objective: The aim of this study was to determine whether interleukin-6 (IL-6) −174 G/C, IL-6 −634 G/C, and interferon-γ (IFN-γ) +874 A/T polymorphisms are associated with susceptibility to recurrent pregnancy loss (RPL). Methods: We conducted a literature search using PubMed and EMBASE databases and performed a meta-analysis using fixed- or random-effects models. Results: A total of 15 articles met the study inclusion criteria. When all study subjects were considered together, meta-analysis showed no association between RPL and the IL-6 −174 GG + GC genotype (odds ratio [OR] = 0.794, 95 {\%} confidence interval [CI] = 0.542–1.163, p = 0.236). However, stratification of the data by ethnicity indicated an association between this genotype and RPL in non-Caucasians (OR = 0.528, 95 {\%} CI = 0.302–0.925, p = 0.028), but not in Caucasian populations. Moreover, meta-analysis revealed an association between RPL and the IL-6 −634 GG + GC genotype in all study subjects (OR = 0.556, 95 {\%} CI = 0.383–0.806, p = 0.002), while stratification by ethnicity revealed a negative association between this genotype and RPL in Asian (OR = 0.545, 95 {\%} CI = 0.371–0.800, p = 0.002) but not Middle Eastern populations. Furthermore, a relationship between the IFN-γ +874 A allele and RPL was identified in non-Caucasians (OR = 1.403, 95 {\%} CI = 1.133–1.734, p = 0.002), but not in Caucasians. Conclusions: This meta-analysis demonstrates that IL-6 −174 G/C, IL-6 −634 G/C, and IFN-γ +874 A/T polymorphisms are associated with susceptibility to RPL, particularly in non-Caucasians.",
keywords = "IFN-γ, IL-6, Meta-analysis, Polymorphism, RPL",
author = "Lee, {Young Ho} and Sungjae Choi and Ji, {Jong Dae}",
year = "2015",
month = "9",
day = "4",
doi = "10.1007/s10815-015-0566-3",
language = "English",
volume = "32",
pages = "1421--1427",
journal = "Journal of Assisted Reproduction and Genetics",
issn = "1058-0468",
publisher = "Springer New York",
number = "9",

}

TY - JOUR

T1 - Association between IL-6 −174 G/C, IL-6 −634 G/C, and IFN-γ +874 A/T polymorphisms and susceptibility to recurrent pregnancy loss

T2 - a meta-analysis

AU - Lee, Young Ho

AU - Choi, Sungjae

AU - Ji, Jong Dae

PY - 2015/9/4

Y1 - 2015/9/4

N2 - Objective: The aim of this study was to determine whether interleukin-6 (IL-6) −174 G/C, IL-6 −634 G/C, and interferon-γ (IFN-γ) +874 A/T polymorphisms are associated with susceptibility to recurrent pregnancy loss (RPL). Methods: We conducted a literature search using PubMed and EMBASE databases and performed a meta-analysis using fixed- or random-effects models. Results: A total of 15 articles met the study inclusion criteria. When all study subjects were considered together, meta-analysis showed no association between RPL and the IL-6 −174 GG + GC genotype (odds ratio [OR] = 0.794, 95 % confidence interval [CI] = 0.542–1.163, p = 0.236). However, stratification of the data by ethnicity indicated an association between this genotype and RPL in non-Caucasians (OR = 0.528, 95 % CI = 0.302–0.925, p = 0.028), but not in Caucasian populations. Moreover, meta-analysis revealed an association between RPL and the IL-6 −634 GG + GC genotype in all study subjects (OR = 0.556, 95 % CI = 0.383–0.806, p = 0.002), while stratification by ethnicity revealed a negative association between this genotype and RPL in Asian (OR = 0.545, 95 % CI = 0.371–0.800, p = 0.002) but not Middle Eastern populations. Furthermore, a relationship between the IFN-γ +874 A allele and RPL was identified in non-Caucasians (OR = 1.403, 95 % CI = 1.133–1.734, p = 0.002), but not in Caucasians. Conclusions: This meta-analysis demonstrates that IL-6 −174 G/C, IL-6 −634 G/C, and IFN-γ +874 A/T polymorphisms are associated with susceptibility to RPL, particularly in non-Caucasians.

AB - Objective: The aim of this study was to determine whether interleukin-6 (IL-6) −174 G/C, IL-6 −634 G/C, and interferon-γ (IFN-γ) +874 A/T polymorphisms are associated with susceptibility to recurrent pregnancy loss (RPL). Methods: We conducted a literature search using PubMed and EMBASE databases and performed a meta-analysis using fixed- or random-effects models. Results: A total of 15 articles met the study inclusion criteria. When all study subjects were considered together, meta-analysis showed no association between RPL and the IL-6 −174 GG + GC genotype (odds ratio [OR] = 0.794, 95 % confidence interval [CI] = 0.542–1.163, p = 0.236). However, stratification of the data by ethnicity indicated an association between this genotype and RPL in non-Caucasians (OR = 0.528, 95 % CI = 0.302–0.925, p = 0.028), but not in Caucasian populations. Moreover, meta-analysis revealed an association between RPL and the IL-6 −634 GG + GC genotype in all study subjects (OR = 0.556, 95 % CI = 0.383–0.806, p = 0.002), while stratification by ethnicity revealed a negative association between this genotype and RPL in Asian (OR = 0.545, 95 % CI = 0.371–0.800, p = 0.002) but not Middle Eastern populations. Furthermore, a relationship between the IFN-γ +874 A allele and RPL was identified in non-Caucasians (OR = 1.403, 95 % CI = 1.133–1.734, p = 0.002), but not in Caucasians. Conclusions: This meta-analysis demonstrates that IL-6 −174 G/C, IL-6 −634 G/C, and IFN-γ +874 A/T polymorphisms are associated with susceptibility to RPL, particularly in non-Caucasians.

KW - IFN-γ

KW - IL-6

KW - Meta-analysis

KW - Polymorphism

KW - RPL

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U2 - 10.1007/s10815-015-0566-3

DO - 10.1007/s10815-015-0566-3

M3 - Article

VL - 32

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EP - 1427

JO - Journal of Assisted Reproduction and Genetics

JF - Journal of Assisted Reproduction and Genetics

SN - 1058-0468

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