TY - JOUR
T1 - Association between interleukin 1 polymorphisms and rheumatoid arthritis susceptibility
T2 - A metaanalysis
AU - Lee, Young Ho
AU - Ji, Jong Dae
AU - Song, Gwan Gyu
PY - 2009/1
Y1 - 2009/1
N2 - Objective. To determine whether interleukin 1 (IL-1) polymorphisms confer susceptibility to rheumatoid arthritis (RA). Methods. We conducted metaanalyses on associations between IL-1 polymorphisms and RA susceptibility, using fixed or random effects models. Results. A total of 18 separate comparisons were made using 10 European, 7 Asian, and 1 Latin American population samples. Metaanalysis of the IL-1B+3954 CC genotype revealed an association with RA in all subjects (odds ratio = 0.776, 95% confidence interval = 0.609-0.988, p = 0.040). In Asians, an association between IL-1B+3954 and RA was identified. In contrast, no association was found between the IL-1B+3954 polymorphism and RA susceptibility in European populations. Metaanalyses of the IL-1B-511 and IL-1RN VNTR polymorphisms identified no association between these polymorphisms and RA. Conclusion. Our metaanalysis shows that the IL-1B+3954 polymorphism was associated with the development of RA, but only in Asians. The Journal of Rheumatology
AB - Objective. To determine whether interleukin 1 (IL-1) polymorphisms confer susceptibility to rheumatoid arthritis (RA). Methods. We conducted metaanalyses on associations between IL-1 polymorphisms and RA susceptibility, using fixed or random effects models. Results. A total of 18 separate comparisons were made using 10 European, 7 Asian, and 1 Latin American population samples. Metaanalysis of the IL-1B+3954 CC genotype revealed an association with RA in all subjects (odds ratio = 0.776, 95% confidence interval = 0.609-0.988, p = 0.040). In Asians, an association between IL-1B+3954 and RA was identified. In contrast, no association was found between the IL-1B+3954 polymorphism and RA susceptibility in European populations. Metaanalyses of the IL-1B-511 and IL-1RN VNTR polymorphisms identified no association between these polymorphisms and RA. Conclusion. Our metaanalysis shows that the IL-1B+3954 polymorphism was associated with the development of RA, but only in Asians. The Journal of Rheumatology
KW - Genetic Polymorphism
KW - Interleukin 1
KW - Rheumatoid arthritis
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U2 - 10.3899/jrheum.080450
DO - 10.3899/jrheum.080450
M3 - Article
C2 - 19004046
AN - SCOPUS:58149502457
SN - 0315-162X
VL - 36
SP - 12
EP - 15
JO - Journal of Rheumatology
JF - Journal of Rheumatology
IS - 1
ER -