Association between interleukin 1 polymorphisms and rheumatoid arthritis susceptibility: A metaanalysis

Young Ho Lee, Jong Dae Ji, Gwan Gyu Song

    Research output: Contribution to journalArticlepeer-review

    19 Citations (Scopus)


    Objective. To determine whether interleukin 1 (IL-1) polymorphisms confer susceptibility to rheumatoid arthritis (RA). Methods. We conducted metaanalyses on associations between IL-1 polymorphisms and RA susceptibility, using fixed or random effects models. Results. A total of 18 separate comparisons were made using 10 European, 7 Asian, and 1 Latin American population samples. Metaanalysis of the IL-1B+3954 CC genotype revealed an association with RA in all subjects (odds ratio = 0.776, 95% confidence interval = 0.609-0.988, p = 0.040). In Asians, an association between IL-1B+3954 and RA was identified. In contrast, no association was found between the IL-1B+3954 polymorphism and RA susceptibility in European populations. Metaanalyses of the IL-1B-511 and IL-1RN VNTR polymorphisms identified no association between these polymorphisms and RA. Conclusion. Our metaanalysis shows that the IL-1B+3954 polymorphism was associated with the development of RA, but only in Asians. The Journal of Rheumatology

    Original languageEnglish
    Pages (from-to)12-15
    Number of pages4
    JournalJournal of Rheumatology
    Issue number1
    Publication statusPublished - 2009 Jan


    • Genetic Polymorphism
    • Interleukin 1
    • Rheumatoid arthritis

    ASJC Scopus subject areas

    • Rheumatology
    • Immunology and Allergy
    • Immunology


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