Association between interleukin-27 polymorphisms and pulmonary tuberculosis

J. Y. Oh, J. K. Sim, W. J. Jung, K. H. Min, E. J. Lee, G. Y. Hur, S. Y. Lee, S. Y. Lee, A. M. Kwon, J. H. Kim, C. Shin, J. J. Shim, K. H. In, K. H. Kang, S. H. Lee

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

OBJECTIVE: To investigate the effect of interleukin (IL) 27-964A/G, 2095T/G, 4603G/A and 4730T/C gene polymorphisms on the development of pulmonary tuberculosis (PTB), radiographic characteristics and severity. DESIGN: Differences in the allele and genotype distributions of the-964A/G, 2095T/G, 4603G/A and 4730T/C polymorphisms between 224 PTB patients and 233 healthy controls, between patients with singleand multi-lobe involvement, and between patients with and without cavitation, were investigated. Serum IL-27 concentration was measured using an enzyme-linked immunosorbent assay. RESULTS: There were no significant differences in the allele or genotype distributions between PTB patients and healthy controls. However, the-964A/A genotype was more prevalent in patients with single-lobe involvement than the-964A/G or-964G/G genotype in patients with multi-lobe involvement (50.0% vs. 31.3%, P = 0.01). There was no difference between patients with and without cavitation (P > 0.05). Serum median IL-27 concentration was significantly higher in patients with single-lobe involvement than in those with multi-lobe involvement (P = 0.03) and in those with-964A/A genotypes than in those with-964A/G or-964G/G genotypes (P = 0.02). CONCLUSIONS: In terms of serum IL-27 levels, the-964 A/A genotype may be associated with a protective role that prevents the intrapulmonary spread of PTB rather than its development.

Original languageEnglish
Pages (from-to)702-708
Number of pages7
JournalInternational Journal of Tuberculosis and Lung Disease
Volume19
Issue number6
DOIs
Publication statusPublished - 2015 Jun 1
Externally publishedYes

Keywords

  • Interleukin-27
  • Single nucleotide polymorphism
  • Tuberculosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

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