Abstract
This study aimed to explore the association between restless legs syndrome and irritable bowel syndrome in an epidemiological cohort. We included 3365 adults, of whom 1602 were female (age 52.5±7.5years), who had participated in the Korean Genome and Epidemiology Study (2005-2006). The diagnosis of restless legs syndrome was based on the criteria proposed by the International Restless Legs Syndrome Study Group, and irritable bowel syndrome was defined according to the Rome II criteria. The prevalence of each condition was determined and their association was tested by logistic regression analysis. Age, sex, haemoglobin concentration, renal insufficiency, use of medications and depressive mood were all adjusted for. The prevalence of restless legs syndrome and irritable bowel syndrome was 4.5 and 11.1%, respectively. Irritable bowel syndrome was more prevalent in the group with restless legs syndrome (24.0 versus 10.5%, P<0.001). Subjects with restless legs syndrome were older (54.2±8.4 versus 52.4±7.4, P=0.006) and more depressive (26.7 versus 12.5%, P<0.001), and were predominantly female (57.3 versus 47.2%, P=0.015), had more frequent insomnia symptoms (44.0 versus 28.2%, P<0.001), had lower haemoglobin concentration (13.7±1.5 versus 14.1±1.6gdL-1P=0.004) and higher highly sensitive C-reactive protein (1.8±5.1 versus 1.4±2.9mgdL-1, P=0.08). The adjusted odds ratio of restless legs syndrome in relation to irritable bowel syndrome was 2.59 (1.74-3.85, P<0.001). Irritable bowel syndrome appeared to be associated with restless legs syndrome independently from other major risk factors for restless legs syndrome. Searching for the mechanisms underlying this association is indicated.
| Original language | English |
|---|---|
| Pages (from-to) | 569-576 |
| Number of pages | 8 |
| Journal | Journal of Sleep Research |
| Volume | 21 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2012 Oct 1 |
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Keywords
- Cohort study
- Irritable bowel syndrome
- Prevalence
- Restless legs syndrome
ASJC Scopus subject areas
- Behavioral Neuroscience
- Cognitive Neuroscience
- Medicine(all)
Cite this
Association between irritable bowel syndrome and restless legs syndrome in the general population. / Yun, Chang Ho; Lee, Seung K.; Kim, Hyun; Park, Hee Kwon; Lee, Seung H.; Kim, Se J.; Shin, Chol.
In: Journal of Sleep Research, Vol. 21, No. 5, 01.10.2012, p. 569-576.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association between irritable bowel syndrome and restless legs syndrome in the general population
AU - Yun, Chang Ho
AU - Lee, Seung K.
AU - Kim, Hyun
AU - Park, Hee Kwon
AU - Lee, Seung H.
AU - Kim, Se J.
AU - Shin, Chol
PY - 2012/10/1
Y1 - 2012/10/1
N2 - This study aimed to explore the association between restless legs syndrome and irritable bowel syndrome in an epidemiological cohort. We included 3365 adults, of whom 1602 were female (age 52.5±7.5years), who had participated in the Korean Genome and Epidemiology Study (2005-2006). The diagnosis of restless legs syndrome was based on the criteria proposed by the International Restless Legs Syndrome Study Group, and irritable bowel syndrome was defined according to the Rome II criteria. The prevalence of each condition was determined and their association was tested by logistic regression analysis. Age, sex, haemoglobin concentration, renal insufficiency, use of medications and depressive mood were all adjusted for. The prevalence of restless legs syndrome and irritable bowel syndrome was 4.5 and 11.1%, respectively. Irritable bowel syndrome was more prevalent in the group with restless legs syndrome (24.0 versus 10.5%, P<0.001). Subjects with restless legs syndrome were older (54.2±8.4 versus 52.4±7.4, P=0.006) and more depressive (26.7 versus 12.5%, P<0.001), and were predominantly female (57.3 versus 47.2%, P=0.015), had more frequent insomnia symptoms (44.0 versus 28.2%, P<0.001), had lower haemoglobin concentration (13.7±1.5 versus 14.1±1.6gdL-1P=0.004) and higher highly sensitive C-reactive protein (1.8±5.1 versus 1.4±2.9mgdL-1, P=0.08). The adjusted odds ratio of restless legs syndrome in relation to irritable bowel syndrome was 2.59 (1.74-3.85, P<0.001). Irritable bowel syndrome appeared to be associated with restless legs syndrome independently from other major risk factors for restless legs syndrome. Searching for the mechanisms underlying this association is indicated.
AB - This study aimed to explore the association between restless legs syndrome and irritable bowel syndrome in an epidemiological cohort. We included 3365 adults, of whom 1602 were female (age 52.5±7.5years), who had participated in the Korean Genome and Epidemiology Study (2005-2006). The diagnosis of restless legs syndrome was based on the criteria proposed by the International Restless Legs Syndrome Study Group, and irritable bowel syndrome was defined according to the Rome II criteria. The prevalence of each condition was determined and their association was tested by logistic regression analysis. Age, sex, haemoglobin concentration, renal insufficiency, use of medications and depressive mood were all adjusted for. The prevalence of restless legs syndrome and irritable bowel syndrome was 4.5 and 11.1%, respectively. Irritable bowel syndrome was more prevalent in the group with restless legs syndrome (24.0 versus 10.5%, P<0.001). Subjects with restless legs syndrome were older (54.2±8.4 versus 52.4±7.4, P=0.006) and more depressive (26.7 versus 12.5%, P<0.001), and were predominantly female (57.3 versus 47.2%, P=0.015), had more frequent insomnia symptoms (44.0 versus 28.2%, P<0.001), had lower haemoglobin concentration (13.7±1.5 versus 14.1±1.6gdL-1P=0.004) and higher highly sensitive C-reactive protein (1.8±5.1 versus 1.4±2.9mgdL-1, P=0.08). The adjusted odds ratio of restless legs syndrome in relation to irritable bowel syndrome was 2.59 (1.74-3.85, P<0.001). Irritable bowel syndrome appeared to be associated with restless legs syndrome independently from other major risk factors for restless legs syndrome. Searching for the mechanisms underlying this association is indicated.
KW - Cohort study
KW - Irritable bowel syndrome
KW - Prevalence
KW - Restless legs syndrome
UR - http://www.scopus.com/inward/record.url?scp=84866753153&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84866753153&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2869.2012.01011.x
DO - 10.1111/j.1365-2869.2012.01011.x
M3 - Article
C2 - 22463600
AN - SCOPUS:84866753153
VL - 21
SP - 569
EP - 576
JO - Journal of Sleep Research
JF - Journal of Sleep Research
SN - 0962-1105
IS - 5
ER -