Abstract
This study investigated the possible effect of the -1438A/G single-nucleotide polymorphism in the promoter region of the serotonin 2A receptor (5-HTR2A) gene on major depressive disorder (MDD) in a Korean population. This polymorphism was analyzed in 189 patients with MDD and in 148 unrelated healthy controls using a case-control design, which revealed a significant difference in the genotype distributions (χ2 = 10.78, d.f. = 2, p = 0.005). The frequency of the -1438G allele was also much higher in MDD patients than in normal controls (χ2 = 7.20, p = 0.007; OR = 1.52, 95% CI 1.12-2.06). We also found significantly more carriers of the G allele (GG+AG genotypes) in MDD patients than in normal controls (χ 2 = 10.18, p = 0.001; OR = 2.46, 95% CI 1.40-4.32). Our results support the hypothesis that the -1438A/G polymorphism of the promoter region of the 5-HTR2A gene is associated with MDD patients in a Korean population.
| Original language | English |
|---|---|
| Pages (from-to) | 38-41 |
| Number of pages | 4 |
| Journal | Neuropsychobiology |
| Volume | 49 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2004 Feb 6 |
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Keywords
- 5-HTR2A
- Major depressive disorder
- Polymorphism
- Promoter
ASJC Scopus subject areas
- Psychiatry and Mental health
- Neuroscience(all)
- Psychology(all)
Cite this
Association between major depressive disorder and the -1438A/G polymorphism of the serotonin 2A receptor gene. / Choi, Myoung Jin; Lee, Heon-Jeong; Lee, Hye Jin; Ham, Byung-Joo; Cha, Ji Hyun; Ryu, Seung Ho; Lee, Min-Soo.
In: Neuropsychobiology, Vol. 49, No. 1, 06.02.2004, p. 38-41.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association between major depressive disorder and the -1438A/G polymorphism of the serotonin 2A receptor gene
AU - Choi, Myoung Jin
AU - Lee, Heon-Jeong
AU - Lee, Hye Jin
AU - Ham, Byung-Joo
AU - Cha, Ji Hyun
AU - Ryu, Seung Ho
AU - Lee, Min-Soo
PY - 2004/2/6
Y1 - 2004/2/6
N2 - This study investigated the possible effect of the -1438A/G single-nucleotide polymorphism in the promoter region of the serotonin 2A receptor (5-HTR2A) gene on major depressive disorder (MDD) in a Korean population. This polymorphism was analyzed in 189 patients with MDD and in 148 unrelated healthy controls using a case-control design, which revealed a significant difference in the genotype distributions (χ2 = 10.78, d.f. = 2, p = 0.005). The frequency of the -1438G allele was also much higher in MDD patients than in normal controls (χ2 = 7.20, p = 0.007; OR = 1.52, 95% CI 1.12-2.06). We also found significantly more carriers of the G allele (GG+AG genotypes) in MDD patients than in normal controls (χ 2 = 10.18, p = 0.001; OR = 2.46, 95% CI 1.40-4.32). Our results support the hypothesis that the -1438A/G polymorphism of the promoter region of the 5-HTR2A gene is associated with MDD patients in a Korean population.
AB - This study investigated the possible effect of the -1438A/G single-nucleotide polymorphism in the promoter region of the serotonin 2A receptor (5-HTR2A) gene on major depressive disorder (MDD) in a Korean population. This polymorphism was analyzed in 189 patients with MDD and in 148 unrelated healthy controls using a case-control design, which revealed a significant difference in the genotype distributions (χ2 = 10.78, d.f. = 2, p = 0.005). The frequency of the -1438G allele was also much higher in MDD patients than in normal controls (χ2 = 7.20, p = 0.007; OR = 1.52, 95% CI 1.12-2.06). We also found significantly more carriers of the G allele (GG+AG genotypes) in MDD patients than in normal controls (χ 2 = 10.18, p = 0.001; OR = 2.46, 95% CI 1.40-4.32). Our results support the hypothesis that the -1438A/G polymorphism of the promoter region of the 5-HTR2A gene is associated with MDD patients in a Korean population.
KW - 5-HTR2A
KW - Major depressive disorder
KW - Polymorphism
KW - Promoter
UR - http://www.scopus.com/inward/record.url?scp=1642496848&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1642496848&partnerID=8YFLogxK
U2 - 10.1159/000075337
DO - 10.1159/000075337
M3 - Article
VL - 49
SP - 38
EP - 41
JO - Neuropsychobiology
JF - Neuropsychobiology
SN - 0302-282X
IS - 1
ER -