Association between maternal exposure to major phthalates, heavy metals, and persistent organic pollutants, and the neurodevelopmental performances of their children at 1 to 2 years of age- CHECK cohort study

Sunmi Kim, Soyong Eom, Hai Joong Kim, Jeong Jae Lee, Gyuyeon Choi, Sooran Choi, Sungjoo Kim, Su Young Kim, Geum-Joon Cho, Young Don Kim, Eunsook Suh, Sung Koo Kim, Seunghyo Kim, Gun Ha Kim, Hyo Bang Moon, Jeongim Park, Sungkyoon Kim, Kyungho Choi, So-Hee Eun

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Exposure of the developing fetus and infants to toxic substances can cause serious lifelong health consequences. Several chemicals have been associated with adverse neurodevelopmental disorders in the early life stages of humans. However, most epidemiological studies have focused on a limited number of chemicals, and hence may exclude important chemicals from consideration or result in conclusions built on associations by chance. In the present study, we investigated the chemical exposure profile of the women, and associated these with the early neurodevelopmental performance of their offspring at 13–24 months of age. The chemicals assessed include four phthalates, bisphenol A, three heavy metals, 19 polychlorinated biphenyls (PCBs), 19 organochlorine pesticides, and 19 polybrominated diphenyl ethers, which were measured from urine, whole blood, serum, and/or breastmilk of the pregnant or lactating women. For neurodevelopmental performance, the Bayley Scales of Infant Development-II (BSID-II), Social Maturity Scale (SMS), and Child Behavior Checklist (CBCL) were measured from a total of 140 toddlers. Among the measured chemicals, monoethyl phthalate (MEP) in maternal urine was significantly associated with early mental, psychomotor, and social development. In addition, breast milk di-ethylhexyl phthalate (DEHP) metabolite and blood lead concentrations were inversely associated with mental and psychomotor development indices, respectively. Maternal blood PCB153, heavy metals, and urinary MEP levels were also higher among the children with behavioral problems, as indicated by the CBCL range. Taken together, maternal exposure to several EDCs such as PCBs and DEHP was associated with adverse neurodevelopmental performances among the children aged 1–2 years. Confirmation of these association in larger populations, as well as longer-term consequences of such exposure warrant further investigation.

Original languageEnglish
Pages (from-to)377-384
Number of pages8
JournalScience of the Total Environment
Volume624
DOIs
Publication statusPublished - 2018 May 15

Fingerprint

Organic pollutants
phthalate
Heavy Metals
Heavy metals
heavy metal
Blood
blood
Polychlorinated Biphenyls
Polychlorinated biphenyls
urine
PCB
Halogenated Diphenyl Ethers
Poisons
toxic substance
PBDE
social development
Metabolites
Pesticides
exposure
persistent organic pollutant

Keywords

  • Bayley scales of infant development (BSID)
  • Breast milk
  • Child behavior checklist (CBCL)
  • Korea
  • Neurodevelopment
  • Prenatal exposure

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Chemistry
  • Waste Management and Disposal
  • Pollution

Cite this

Association between maternal exposure to major phthalates, heavy metals, and persistent organic pollutants, and the neurodevelopmental performances of their children at 1 to 2 years of age- CHECK cohort study. / Kim, Sunmi; Eom, Soyong; Kim, Hai Joong; Lee, Jeong Jae; Choi, Gyuyeon; Choi, Sooran; Kim, Sungjoo; Kim, Su Young; Cho, Geum-Joon; Kim, Young Don; Suh, Eunsook; Kim, Sung Koo; Kim, Seunghyo; Kim, Gun Ha; Moon, Hyo Bang; Park, Jeongim; Kim, Sungkyoon; Choi, Kyungho; Eun, So-Hee.

In: Science of the Total Environment, Vol. 624, 15.05.2018, p. 377-384.

Research output: Contribution to journalArticle

Kim, Sunmi ; Eom, Soyong ; Kim, Hai Joong ; Lee, Jeong Jae ; Choi, Gyuyeon ; Choi, Sooran ; Kim, Sungjoo ; Kim, Su Young ; Cho, Geum-Joon ; Kim, Young Don ; Suh, Eunsook ; Kim, Sung Koo ; Kim, Seunghyo ; Kim, Gun Ha ; Moon, Hyo Bang ; Park, Jeongim ; Kim, Sungkyoon ; Choi, Kyungho ; Eun, So-Hee. / Association between maternal exposure to major phthalates, heavy metals, and persistent organic pollutants, and the neurodevelopmental performances of their children at 1 to 2 years of age- CHECK cohort study. In: Science of the Total Environment. 2018 ; Vol. 624. pp. 377-384.
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