Association between menarche and increased bronchial hyper-responsiveness during puberty in female children and adolescents

Young Ho Kim, Eun Lee, Hyun Ju Cho, Song I. Yang, Young Ho Jung, Hyung Young Kim, Ju Hee Seo, Hyo Bin Kim, So Yeon Lee, Dae-Jin Song, Woo Kyung Kim, Gwang Cheon Jang, Jung Yeon Shim, Eun Jin Kim, Joo Shil Lee, Ji Won Kwon, Soo Jong Hong

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purpose: Bronchial hyper-responsiveness (BHR) is a key feature of asthma. The degree of BHR in children may be altered by several factors. We evaluated the prevalence of BHR according to age and gender in pediatric and adolescent population and analyzed the associated factors for gender differences. Methods: Among the 2,067 subjects, methacholine challenge tests were performed in 1,820 children from one elementary and one middle school in Seoul, Korea. A total of 1,725 subjects between 6 and 14 years old were included in the analysis. The prevalence of BHR, defined as a provocative concentration that induced a 20% reduction of FEV1 (PC20) that was less than 8 mg/ml, was evaluated according to age and gender. Gender differences associated with BHR prevalence at each age were calculated and multiple logistic regression analyses were performed to identify factors associated with BHR by gender. Results: The prevalence of BHR (PC20 ≤ 8 mg/ml) for each gender decreased with age (P < 0.001). Although the prevalence of BHR linearly decreased in males with age, females showed an increase after 11 years of age. BHR in males was associated with a younger age (aOR, 0.797; 95%CI, 0.678–0.925), a higher blood eosinophil counts (%) (aOR, 1.160; 95%CI, 1.047–1.284), atopy (aOR, 2.091; 95%CI, 1.003–4.359), and a lower FEV1/FVC ratio (aOR, 0.947; 95%CI, 0.901–0.995), and FEF25–75% (aOR, 0.980; 95%CI, 0.961–0.999). In females, BHR was significantly associated with a younger age (aOR, 0.845; 95%CI, 0.747–0.957), lower FEV1 (%) (aOR, 0.961; 95%CI, 0.938–0.984), and menarche (aOR, 3.674; 95%CI, 1.226–11.012). Conclusion: BHR declined with age in the Korean pediatric population. A younger age and reduced lung function were common factors related to BHR in both genders. Additionally, atopy was related to BHR in males, whereas sexual maturation was related to BHR in females. These findings have important clinical implications for evaluating of childhood BHR and asthma related to gender. Pediatr Pulmonol. 2016;51:1040–1047.

Original languageEnglish
Pages (from-to)1040-1047
Number of pages8
JournalPediatric Pulmonology
Volume51
Issue number10
DOIs
Publication statusPublished - 2016 Oct 1

Fingerprint

Menarche
Puberty
Asthma
Pediatrics
Sexual Maturation
Methacholine Chloride
Korea
Eosinophils
Population
Logistic Models
Regression Analysis
Lung

Keywords

  • atopy
  • bronchial hyper-responsiveness
  • child
  • gender
  • menarche

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

Cite this

Association between menarche and increased bronchial hyper-responsiveness during puberty in female children and adolescents. / Kim, Young Ho; Lee, Eun; Cho, Hyun Ju; Yang, Song I.; Jung, Young Ho; Kim, Hyung Young; Seo, Ju Hee; Kim, Hyo Bin; Lee, So Yeon; Song, Dae-Jin; Kim, Woo Kyung; Jang, Gwang Cheon; Shim, Jung Yeon; Kim, Eun Jin; Lee, Joo Shil; Kwon, Ji Won; Hong, Soo Jong.

In: Pediatric Pulmonology, Vol. 51, No. 10, 01.10.2016, p. 1040-1047.

Research output: Contribution to journalArticle

Kim, YH, Lee, E, Cho, HJ, Yang, SI, Jung, YH, Kim, HY, Seo, JH, Kim, HB, Lee, SY, Song, D-J, Kim, WK, Jang, GC, Shim, JY, Kim, EJ, Lee, JS, Kwon, JW & Hong, SJ 2016, 'Association between menarche and increased bronchial hyper-responsiveness during puberty in female children and adolescents', Pediatric Pulmonology, vol. 51, no. 10, pp. 1040-1047. https://doi.org/10.1002/ppul.23433
Kim, Young Ho ; Lee, Eun ; Cho, Hyun Ju ; Yang, Song I. ; Jung, Young Ho ; Kim, Hyung Young ; Seo, Ju Hee ; Kim, Hyo Bin ; Lee, So Yeon ; Song, Dae-Jin ; Kim, Woo Kyung ; Jang, Gwang Cheon ; Shim, Jung Yeon ; Kim, Eun Jin ; Lee, Joo Shil ; Kwon, Ji Won ; Hong, Soo Jong. / Association between menarche and increased bronchial hyper-responsiveness during puberty in female children and adolescents. In: Pediatric Pulmonology. 2016 ; Vol. 51, No. 10. pp. 1040-1047.
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abstract = "Purpose: Bronchial hyper-responsiveness (BHR) is a key feature of asthma. The degree of BHR in children may be altered by several factors. We evaluated the prevalence of BHR according to age and gender in pediatric and adolescent population and analyzed the associated factors for gender differences. Methods: Among the 2,067 subjects, methacholine challenge tests were performed in 1,820 children from one elementary and one middle school in Seoul, Korea. A total of 1,725 subjects between 6 and 14 years old were included in the analysis. The prevalence of BHR, defined as a provocative concentration that induced a 20{\%} reduction of FEV1 (PC20) that was less than 8 mg/ml, was evaluated according to age and gender. Gender differences associated with BHR prevalence at each age were calculated and multiple logistic regression analyses were performed to identify factors associated with BHR by gender. Results: The prevalence of BHR (PC20 ≤ 8 mg/ml) for each gender decreased with age (P < 0.001). Although the prevalence of BHR linearly decreased in males with age, females showed an increase after 11 years of age. BHR in males was associated with a younger age (aOR, 0.797; 95{\%}CI, 0.678–0.925), a higher blood eosinophil counts ({\%}) (aOR, 1.160; 95{\%}CI, 1.047–1.284), atopy (aOR, 2.091; 95{\%}CI, 1.003–4.359), and a lower FEV1/FVC ratio (aOR, 0.947; 95{\%}CI, 0.901–0.995), and FEF25–75{\%} (aOR, 0.980; 95{\%}CI, 0.961–0.999). In females, BHR was significantly associated with a younger age (aOR, 0.845; 95{\%}CI, 0.747–0.957), lower FEV1 ({\%}) (aOR, 0.961; 95{\%}CI, 0.938–0.984), and menarche (aOR, 3.674; 95{\%}CI, 1.226–11.012). Conclusion: BHR declined with age in the Korean pediatric population. A younger age and reduced lung function were common factors related to BHR in both genders. Additionally, atopy was related to BHR in males, whereas sexual maturation was related to BHR in females. These findings have important clinical implications for evaluating of childhood BHR and asthma related to gender. Pediatr Pulmonol. 2016;51:1040–1047.",
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T1 - Association between menarche and increased bronchial hyper-responsiveness during puberty in female children and adolescents

AU - Kim, Young Ho

AU - Lee, Eun

AU - Cho, Hyun Ju

AU - Yang, Song I.

AU - Jung, Young Ho

AU - Kim, Hyung Young

AU - Seo, Ju Hee

AU - Kim, Hyo Bin

AU - Lee, So Yeon

AU - Song, Dae-Jin

AU - Kim, Woo Kyung

AU - Jang, Gwang Cheon

AU - Shim, Jung Yeon

AU - Kim, Eun Jin

AU - Lee, Joo Shil

AU - Kwon, Ji Won

AU - Hong, Soo Jong

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Purpose: Bronchial hyper-responsiveness (BHR) is a key feature of asthma. The degree of BHR in children may be altered by several factors. We evaluated the prevalence of BHR according to age and gender in pediatric and adolescent population and analyzed the associated factors for gender differences. Methods: Among the 2,067 subjects, methacholine challenge tests were performed in 1,820 children from one elementary and one middle school in Seoul, Korea. A total of 1,725 subjects between 6 and 14 years old were included in the analysis. The prevalence of BHR, defined as a provocative concentration that induced a 20% reduction of FEV1 (PC20) that was less than 8 mg/ml, was evaluated according to age and gender. Gender differences associated with BHR prevalence at each age were calculated and multiple logistic regression analyses were performed to identify factors associated with BHR by gender. Results: The prevalence of BHR (PC20 ≤ 8 mg/ml) for each gender decreased with age (P < 0.001). Although the prevalence of BHR linearly decreased in males with age, females showed an increase after 11 years of age. BHR in males was associated with a younger age (aOR, 0.797; 95%CI, 0.678–0.925), a higher blood eosinophil counts (%) (aOR, 1.160; 95%CI, 1.047–1.284), atopy (aOR, 2.091; 95%CI, 1.003–4.359), and a lower FEV1/FVC ratio (aOR, 0.947; 95%CI, 0.901–0.995), and FEF25–75% (aOR, 0.980; 95%CI, 0.961–0.999). In females, BHR was significantly associated with a younger age (aOR, 0.845; 95%CI, 0.747–0.957), lower FEV1 (%) (aOR, 0.961; 95%CI, 0.938–0.984), and menarche (aOR, 3.674; 95%CI, 1.226–11.012). Conclusion: BHR declined with age in the Korean pediatric population. A younger age and reduced lung function were common factors related to BHR in both genders. Additionally, atopy was related to BHR in males, whereas sexual maturation was related to BHR in females. These findings have important clinical implications for evaluating of childhood BHR and asthma related to gender. Pediatr Pulmonol. 2016;51:1040–1047.

AB - Purpose: Bronchial hyper-responsiveness (BHR) is a key feature of asthma. The degree of BHR in children may be altered by several factors. We evaluated the prevalence of BHR according to age and gender in pediatric and adolescent population and analyzed the associated factors for gender differences. Methods: Among the 2,067 subjects, methacholine challenge tests were performed in 1,820 children from one elementary and one middle school in Seoul, Korea. A total of 1,725 subjects between 6 and 14 years old were included in the analysis. The prevalence of BHR, defined as a provocative concentration that induced a 20% reduction of FEV1 (PC20) that was less than 8 mg/ml, was evaluated according to age and gender. Gender differences associated with BHR prevalence at each age were calculated and multiple logistic regression analyses were performed to identify factors associated with BHR by gender. Results: The prevalence of BHR (PC20 ≤ 8 mg/ml) for each gender decreased with age (P < 0.001). Although the prevalence of BHR linearly decreased in males with age, females showed an increase after 11 years of age. BHR in males was associated with a younger age (aOR, 0.797; 95%CI, 0.678–0.925), a higher blood eosinophil counts (%) (aOR, 1.160; 95%CI, 1.047–1.284), atopy (aOR, 2.091; 95%CI, 1.003–4.359), and a lower FEV1/FVC ratio (aOR, 0.947; 95%CI, 0.901–0.995), and FEF25–75% (aOR, 0.980; 95%CI, 0.961–0.999). In females, BHR was significantly associated with a younger age (aOR, 0.845; 95%CI, 0.747–0.957), lower FEV1 (%) (aOR, 0.961; 95%CI, 0.938–0.984), and menarche (aOR, 3.674; 95%CI, 1.226–11.012). Conclusion: BHR declined with age in the Korean pediatric population. A younger age and reduced lung function were common factors related to BHR in both genders. Additionally, atopy was related to BHR in males, whereas sexual maturation was related to BHR in females. These findings have important clinical implications for evaluating of childhood BHR and asthma related to gender. Pediatr Pulmonol. 2016;51:1040–1047.

KW - atopy

KW - bronchial hyper-responsiveness

KW - child

KW - gender

KW - menarche

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