Association between microbiota and nasal mucosal diseases in terms of immunity

Junhu Tai; Mun Soo Han; Jiwon Kwak; Tae Hoon Kim

doi:10.3390/ijms22094744

Association between microbiota and nasal mucosal diseases in terms of immunity

Junhu Tai, Mun Soo Han, Jiwon Kwak, Tae Hoon Kim

Department of Biomedical Sciences

Research output: Contribution to journal › Review article › peer-review

5 Citations (Scopus)

Abstract

The pathogenesis of nasal inflammatory diseases is related to various factors such as anatomical structure, heredity, and environment. The nasal microbiota play a key role in coordinating immune system functions. Dysfunction of the microbiota has a significant impact on the occurrence and development of nasal inflammation. This review will introduce the positive and negative roles of microbiota involved in immunity surrounding nasal mucosal diseases such as chronic sinusitis and allergic rhinitis. In addition, we will also introduce recent developments in DNA sequencing, metabolomics, and proteomics combined with computation-based bioinformatics.

Original language	English
Article number	4744
Journal	International journal of molecular sciences
Volume	22
Issue number	9
DOIs	https://doi.org/10.3390/ijms22094744
Publication status	Published - 2021 May 1

Keywords

Allergic rhinitis
Chronic rhinosinusitis
Immunity
Microbiota
Nasal mucosa

ASJC Scopus subject areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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10.3390/ijms22094744

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title = "Association between microbiota and nasal mucosal diseases in terms of immunity",

abstract = "The pathogenesis of nasal inflammatory diseases is related to various factors such as anatomical structure, heredity, and environment. The nasal microbiota play a key role in coordinating immune system functions. Dysfunction of the microbiota has a significant impact on the occurrence and development of nasal inflammation. This review will introduce the positive and negative roles of microbiota involved in immunity surrounding nasal mucosal diseases such as chronic sinusitis and allergic rhinitis. In addition, we will also introduce recent developments in DNA sequencing, metabolomics, and proteomics combined with computation-based bioinformatics.",

keywords = "Allergic rhinitis, Chronic rhinosinusitis, Immunity, Microbiota, Nasal mucosa",

author = "Junhu Tai and Han, {Mun Soo} and Jiwon Kwak and Kim, {Tae Hoon}",

note = "Funding Information: Funding: This research was supported by the Basic Science Research Program and National Research Foundation of Korea, and was funded by the Ministry of Science and Technology and the Ministry of Science, ICT & Future Planning (2017R1A2B2003575 and NRF-2020R1A2C1006398), and the Ministry of Science and ICT (2020R1C1C1012288), Korea, under the ICT Creative Consilience program (IITP-2021-0-01819) supervised by the IITP (Institute for Information & Communications Technology Planning & Evaluation), the Korea Health Technology R&D Project (HI17C0387), the Korea Health Industry Development Institute (KHIDI), and the Ministry of Health & Welfare. This research was also supported by a Korea University grant and a grant from the Korea University Medical Center and Anam Hospital, Seoul, Republic of Korea. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = may,

day = "1",

doi = "10.3390/ijms22094744",

language = "English",

volume = "22",

journal = "International Journal of Molecular Sciences",

issn = "1661-6596",

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TY - JOUR

T1 - Association between microbiota and nasal mucosal diseases in terms of immunity

AU - Tai, Junhu

AU - Han, Mun Soo

AU - Kwak, Jiwon

AU - Kim, Tae Hoon

N1 - Funding Information: Funding: This research was supported by the Basic Science Research Program and National Research Foundation of Korea, and was funded by the Ministry of Science and Technology and the Ministry of Science, ICT & Future Planning (2017R1A2B2003575 and NRF-2020R1A2C1006398), and the Ministry of Science and ICT (2020R1C1C1012288), Korea, under the ICT Creative Consilience program (IITP-2021-0-01819) supervised by the IITP (Institute for Information & Communications Technology Planning & Evaluation), the Korea Health Technology R&D Project (HI17C0387), the Korea Health Industry Development Institute (KHIDI), and the Ministry of Health & Welfare. This research was also supported by a Korea University grant and a grant from the Korea University Medical Center and Anam Hospital, Seoul, Republic of Korea. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/5/1

Y1 - 2021/5/1

N2 - The pathogenesis of nasal inflammatory diseases is related to various factors such as anatomical structure, heredity, and environment. The nasal microbiota play a key role in coordinating immune system functions. Dysfunction of the microbiota has a significant impact on the occurrence and development of nasal inflammation. This review will introduce the positive and negative roles of microbiota involved in immunity surrounding nasal mucosal diseases such as chronic sinusitis and allergic rhinitis. In addition, we will also introduce recent developments in DNA sequencing, metabolomics, and proteomics combined with computation-based bioinformatics.

AB - The pathogenesis of nasal inflammatory diseases is related to various factors such as anatomical structure, heredity, and environment. The nasal microbiota play a key role in coordinating immune system functions. Dysfunction of the microbiota has a significant impact on the occurrence and development of nasal inflammation. This review will introduce the positive and negative roles of microbiota involved in immunity surrounding nasal mucosal diseases such as chronic sinusitis and allergic rhinitis. In addition, we will also introduce recent developments in DNA sequencing, metabolomics, and proteomics combined with computation-based bioinformatics.

KW - Allergic rhinitis

KW - Chronic rhinosinusitis

KW - Immunity

KW - Microbiota

KW - Nasal mucosa

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U2 - 10.3390/ijms22094744

DO - 10.3390/ijms22094744

M3 - Review article

C2 - 33947066

AN - SCOPUS:85105506400

SN - 1661-6596

VL - 22

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 9

M1 - 4744

ER -

Association between microbiota and nasal mucosal diseases in terms of immunity

Abstract

Keywords

ASJC Scopus subject areas

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