Association between monoamine oxidase A polymorphisms and anger-related personality traits in Korean women

Jae Won Yang, So Hee Lee, Seung Ho Ryu, Boung Chul Lee, Seung Hyun Kim, Sook Haeng Joe, In Kwa Jung, Ihn Geun Choi, Byung Joo Ham

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

It has been suggested that polymorphisms in the monoamine oxidase A (MAO-A) gene are associated with aggressive and impulsive behaviors. In the present study, we investigated the association of the MAO-A variable number of tandem repeat polymorphism in the promoter region (MAO-A uVNTR) with anger-related personality traits. Specifically, MAO-A uVNTR polymorphisms were examined for associations with the State-Trait Anger Expression Inventory (STAXI) scores in 211 normal Korean women. All subjects were assessed using the STAXI and genotyped for MAO-A uVNTR status. The scores on the STAXI subscales differed significantly among the MAO-A uVNTR polymorphism genotypes in terms of anger expression-out (AX-Out) scores. Post hoc comparisons revealed significant differences between the 3/3 and 4/4, and between 3/4 and 4/4 polymorphisms. However, no significant difference was observed in other STAXI subscale scores among these genotypes. Subjects with the high-activity MAO-A uVNTR had significantly higher AX-Out scores than subjects with other genotypes. MAO-A uVNTR polymorphisms may contribute in part to the expression of anger. These findings support the hypothesis that this polymorphism in the MAO-A gene may be associated with anger-related personality traits in Korean women.

Original languageEnglish
Pages (from-to)19-23
Number of pages5
JournalNeuropsychobiology
Volume56
Issue number1
DOIs
Publication statusPublished - 2007 Nov

Keywords

  • Anger-related behavior
  • Monoamine oxidase A gene
  • Polymorphism

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Psychiatry and Mental health
  • Biological Psychiatry

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