Association between norepinephrine transporter gene polymorphism and major depression

Seung Ho Ryu, Seung Hwan Lee, Heon-Jeong Lee, Ji Hyun Cha, Byung-Joo Ham, Changsu Han, Myoung Jin Choi, Min-Soo Lee

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Noradrenergic and serotonergic abnormalities have long been implicated in patients with major depression. The novel selective norepinephrine reuptake inhibitor reboxetine has been shown to be at least as effective as imipramine, desipramine and fluoxetine in the treatment of major depression. It is suggested that the dysfunction of the norepinephrine transporter (NET) may be related to major depression. Although the transcriptional activity related to the NET gene expression is little known, it may be a good candidate gene for major depression. Therefore, we investigated whether the T-182C polymorphism of the NET gene is associated with major depression in a Korean sample of 112 major depression patients compared with 136 healthy controls. We found a significantly lower frequency in TT genotype in patients with major depression than in normal controls when the genotypes of T-182C polymorphism were classified into two groups: TT group versus TC + CC group (p = 0.019). This result suggests that the T-182C polymorphism in the NET gene might be associated with major depression.

Original languageEnglish
Pages (from-to)174-177
Number of pages4
JournalNeuropsychobiology
Volume49
Issue number4
DOIs
Publication statusPublished - 2004 May 20

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Norepinephrine Plasma Membrane Transport Proteins
Genes
Genotype
Desipramine
Imipramine
Fluoxetine
Norepinephrine
Gene Expression

Keywords

  • Association study
  • Major depression
  • Norepinephrine transporter gene
  • Polymorphism

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)
  • Psychology(all)

Cite this

Association between norepinephrine transporter gene polymorphism and major depression. / Ryu, Seung Ho; Lee, Seung Hwan; Lee, Heon-Jeong; Cha, Ji Hyun; Ham, Byung-Joo; Han, Changsu; Choi, Myoung Jin; Lee, Min-Soo.

In: Neuropsychobiology, Vol. 49, No. 4, 20.05.2004, p. 174-177.

Research output: Contribution to journalArticle

Ryu, Seung Ho ; Lee, Seung Hwan ; Lee, Heon-Jeong ; Cha, Ji Hyun ; Ham, Byung-Joo ; Han, Changsu ; Choi, Myoung Jin ; Lee, Min-Soo. / Association between norepinephrine transporter gene polymorphism and major depression. In: Neuropsychobiology. 2004 ; Vol. 49, No. 4. pp. 174-177.
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