Abstract
Background Although several studies have investigated possible associations between norepinephrine neurotransmitter transporter gene (SLC6A2) polymorphisms and depression, few studies have examined associations between SLC6A2 polymorphisms and suicide. Methods Three single-nucleotide polymorphisms (rs2242446, rs28386840, and rs5569) were measured in 550 patients: 201 with major depressive disorder (MDD) and suicide attempt/s, 160 with MDD without suicide attempts, and 189 healthy controls. Analysis of single-nucleotide polymorphisms (SNPs) and haplotype was conducted for the three groups. Subsequently, multivariate logistic regression analysis adjusting for age and gender was conducted to identify independent influences of each SNP. A possible association between suicide lethality and SLC6A2 polymorphisms was also investigated. Results In the genotype and allele frequency analysis, there were significant differences in rs28386840 between suicidal MDD patients and healthy controls. In the haplotype analysis, TAA (rs2242446-rs28386840-rs5569, from left to right) was associated with suicide attempts in MDD, although the significance (p=0.043) disappeared after Bonferroni correction. There were no relationships between lethality scores and SLC6A2 polymorphisms in suicidal MDD. Limitations Modest sample size and a single type of neurotransmitter analyzed (norepinephrine) are the primary limitations. Conclusion Our results suggest that SLC6A2 polymorphisms were associated with suicide risk in patients with MDD. Future studies are warranted to elucidate possible mechanisms by which SLC6A2 polymorphisms influence suicide risk.
| Original language | English |
|---|---|
| Pages (from-to) | 127-132 |
| Number of pages | 6 |
| Journal | Journal of Affective Disorders |
| Volume | 158 |
| DOIs | |
| Publication status | Published - 2014 Apr 1 |
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Keywords
- Depression
- Single nucleotide polymorphisms
- SLC6A2
- Suicide
ASJC Scopus subject areas
- Psychiatry and Mental health
- Clinical Psychology
Cite this
Association between norepinephrine transporter gene (SLC6A2) polymorphisms and suicide in patients with major depressive disorder. / Kim, Yong Ku; Hwang, Jung A.; Lee, Heon-Jeong; Yoon, Ho-Kyoung; Ko, Young-Hoon; Lee, Bun Hee; Jung, Han Yong; Hahn, Sang Woo; Na, Kyoung Sae.
In: Journal of Affective Disorders, Vol. 158, 01.04.2014, p. 127-132.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association between norepinephrine transporter gene (SLC6A2) polymorphisms and suicide in patients with major depressive disorder
AU - Kim, Yong Ku
AU - Hwang, Jung A.
AU - Lee, Heon-Jeong
AU - Yoon, Ho-Kyoung
AU - Ko, Young-Hoon
AU - Lee, Bun Hee
AU - Jung, Han Yong
AU - Hahn, Sang Woo
AU - Na, Kyoung Sae
PY - 2014/4/1
Y1 - 2014/4/1
N2 - Background Although several studies have investigated possible associations between norepinephrine neurotransmitter transporter gene (SLC6A2) polymorphisms and depression, few studies have examined associations between SLC6A2 polymorphisms and suicide. Methods Three single-nucleotide polymorphisms (rs2242446, rs28386840, and rs5569) were measured in 550 patients: 201 with major depressive disorder (MDD) and suicide attempt/s, 160 with MDD without suicide attempts, and 189 healthy controls. Analysis of single-nucleotide polymorphisms (SNPs) and haplotype was conducted for the three groups. Subsequently, multivariate logistic regression analysis adjusting for age and gender was conducted to identify independent influences of each SNP. A possible association between suicide lethality and SLC6A2 polymorphisms was also investigated. Results In the genotype and allele frequency analysis, there were significant differences in rs28386840 between suicidal MDD patients and healthy controls. In the haplotype analysis, TAA (rs2242446-rs28386840-rs5569, from left to right) was associated with suicide attempts in MDD, although the significance (p=0.043) disappeared after Bonferroni correction. There were no relationships between lethality scores and SLC6A2 polymorphisms in suicidal MDD. Limitations Modest sample size and a single type of neurotransmitter analyzed (norepinephrine) are the primary limitations. Conclusion Our results suggest that SLC6A2 polymorphisms were associated with suicide risk in patients with MDD. Future studies are warranted to elucidate possible mechanisms by which SLC6A2 polymorphisms influence suicide risk.
AB - Background Although several studies have investigated possible associations between norepinephrine neurotransmitter transporter gene (SLC6A2) polymorphisms and depression, few studies have examined associations between SLC6A2 polymorphisms and suicide. Methods Three single-nucleotide polymorphisms (rs2242446, rs28386840, and rs5569) were measured in 550 patients: 201 with major depressive disorder (MDD) and suicide attempt/s, 160 with MDD without suicide attempts, and 189 healthy controls. Analysis of single-nucleotide polymorphisms (SNPs) and haplotype was conducted for the three groups. Subsequently, multivariate logistic regression analysis adjusting for age and gender was conducted to identify independent influences of each SNP. A possible association between suicide lethality and SLC6A2 polymorphisms was also investigated. Results In the genotype and allele frequency analysis, there were significant differences in rs28386840 between suicidal MDD patients and healthy controls. In the haplotype analysis, TAA (rs2242446-rs28386840-rs5569, from left to right) was associated with suicide attempts in MDD, although the significance (p=0.043) disappeared after Bonferroni correction. There were no relationships between lethality scores and SLC6A2 polymorphisms in suicidal MDD. Limitations Modest sample size and a single type of neurotransmitter analyzed (norepinephrine) are the primary limitations. Conclusion Our results suggest that SLC6A2 polymorphisms were associated with suicide risk in patients with MDD. Future studies are warranted to elucidate possible mechanisms by which SLC6A2 polymorphisms influence suicide risk.
KW - Depression
KW - Single nucleotide polymorphisms
KW - SLC6A2
KW - Suicide
UR - http://www.scopus.com/inward/record.url?scp=84896872606&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84896872606&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2014.01.018
DO - 10.1016/j.jad.2014.01.018
M3 - Article
C2 - 24655776
AN - SCOPUS:84896872606
VL - 158
SP - 127
EP - 132
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
ER -