Association between occupational dust exposure and prognosis of idiopathic pulmonary fibrosis: A Korean national survey

Sang Hoon Lee, Dong Soon Kim, Young Whan Kim, Man Pyo Chung, Soo Taek Uh, Choon Sik Park, Sung Hwan Jeong, Yong Bum Park, Hong Lyeol Lee, Jeong Sup Song, Jong Wook Shin, Nam Soo Yoo, Eun Joo Lee, Jin Hwa Lee, Yangin Jegal, Hyun Kyung Lee, Moo Suk Park

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25 Citations (Scopus)

Abstract

BACKGROUND: Previous studies have investigated the relationship between occupational and environmental agents and idiopathic pulmonary fibrosis (IPF). However, there have been few studies regarding the prognosis of patients with IPF according to patient occupation. METHODS: We investigated whether occupational dust exposure was associated with clinically decreased lung function and poor prognosis. The Korean Interstitial Lung Disease Research Group conducted a national survey to evaluate the clinical, physiologic, radiologic, and survival characteristics of patients with IPF. A total of 1,311 patients with IPF were stratified into five groups according to their occupation: (1) unemployed or homemakers (n = 628); (2) farmers, fishers, or ranchers (n 5 230); (3) sales or service personnel (n = 131); (4) clerical or professional personnel (n = 151); and (5) specific dust-exposed workers (n = 171). RESULTS: The mean age of subjects at diagnosis, was 67.5 ± 9.7 years. Current smokers were 336 patients, 435 were exsmokers, and 456 were never smokers. Dust-exposed workers showed early onset of IPF (61.3 ± 8.6 years; P < .001) and a longer duration of symptoms at diagnosis (17.0 ± 28.2 months; P = .004). Aging (P = .001; hazard ratio [HR], 1.034; 95% CI, 1.014-1.054), FVC % predicted at diagnosis (P = .004; HR, 0.984; 95% CI, 0.974-0.995), and dust-exposure occupation (P = .033; HR, 1.813; 95% CI, 1.049-3.133) were associated with mortality. CONCLUSIONS: These findings indicate that occupational dust may be an aggravating factor associated with a poor prognosis in IPF.

Original languageEnglish
Pages (from-to)465-474
Number of pages10
JournalChest
Volume147
Issue number2
DOIs
Publication statusPublished - 2015 Feb 1

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

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    Lee, S. H., Kim, D. S., Kim, Y. W., Chung, M. P., Uh, S. T., Park, C. S., Jeong, S. H., Park, Y. B., Lee, H. L., Song, J. S., Shin, J. W., Yoo, N. S., Lee, E. J., Lee, J. H., Jegal, Y., Lee, H. K., & Park, M. S. (2015). Association between occupational dust exposure and prognosis of idiopathic pulmonary fibrosis: A Korean national survey. Chest, 147(2), 465-474. https://doi.org/10.1378/chest.14-0994