Association between Optic Disc Hemorrhage and Renal Function in South Korea

Jae Yeun Lee, Joon Mo Kim, Seong Hee Shim, Jin Young Lee, Chungkwon Yoo, Yu Sam Won, Young Youl Hyun, Ki Ho Park

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Purpose: The purpose of this article is to investigate the relationship between renal function and disc hemorrhage (DH). Materials and Methods: This retrospective cross-sectional survey was conducted at Kangbuk Samsung Hospital Health Screening Center between August 2012 and July 2013, and a total of 168,044 participants at least 20 years of age who voluntarily visited the health screening center for systemic and ophthalmologic examinations, including fundus photography, were enrolled. All subjects underwent a physical examination and provided samples for laboratory analysis. Digital fundus photographs of both eyes were taken and reviewed. Estimated glomerular filtration rate (eGFR) was calculated from serum creatinine concentration using the Modification of Diet in Renal Disease (MDRD) formula and Cockcroft-Gault (CG) formula. Subjects were stratified by eGFR into quartiles. Results: Among participants, 220 (0.1%) showed DH, and 2376 (1.6%) showed glaucomatous retinal nerve fiber layer defects. The DH group showed higher creatinine and lower eGFR than the non-DH group. A significant trend was observed among higher creatinine, decreased eGFR as obtained by the MDRD and CG formulas, and the prevalence of DH (P for trend ≤0.003, logistic regression analysis). A multiple logistic regression model adjusted for age, sex, hypertension, diabetes, and hyperlipidemia showed that the lowest eGFR quartiles estimated by MDRD and CG were significantly associated with DH compared with the highest eGFR quartile (adjusted odds ratio, 1.96; 95% confidence interval, 1.22-3.14 by CG, 1.86; 95% confidence interval, 1.17-2.96 by MDRD). Conclusion: Renal function impairment was independently associated with a higher prevalence of DH in a South Korean population.

    Original languageEnglish
    Pages (from-to)251-256
    Number of pages6
    JournalJournal of glaucoma
    Volume27
    Issue number3
    DOIs
    Publication statusPublished - 2018

    Keywords

    • disc hemorrhage
    • glaucoma
    • kidney function

    ASJC Scopus subject areas

    • Ophthalmology

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