Association Between Optic Disc Hemorrhage and Renal Function in South Korea

Jae Yeun Lee, Joon Mo Kim, Seong Hee Shim, Jin Young Lee, Chungkwon Yoo, Ji Yoon Song, Yu Sam Won, Young Youl Hyun, Ki Ho Park

Research output: Contribution to journalArticle

Abstract

Purpose: To investigate the relationship between renal function and disc hemorrhage (DH). Methods: This retrospective cross-sectional survey was conducted at Kangbuk Samsung Hospital Health Screening Center between August 2012 and July 2013, and a total of 168,044 participants at least 20 years of age who voluntarily visited the health screening center for systemic and ophthalmologic examinations, including fundus photography, were enrolled. All subjects underwent a physical examination and provided samples for laboratory analysis. Digital fundus photographs of both eyes were taken and reviewed. Estimated glomerular filtration rate (eGFR) was calculated from serum creatinine concentration using the Modification of Diet in Renal Disease (MDRD) formula and Cockcroft-Gault (CG) formula. Subjects were stratified by eGFR into quartiles. Results: Among participants, 220 (0.1%) showed DH, and 2,376 (1.6%) showed glaucomatous retinal nerve fiber layer (RNFL) defects. The DH group showed higher creatinine and lower eGFR than the non-DH group. A significant trend was observed among higher creatinine, decreased eGFR as obtained by the MDRD and CG formulas, and the prevalence of DH (P for Trend ≤0.003, logistic regression analysis). A multiple logistic regression model adjusted for age, sex, hypertension, diabetes, and hyperlipidemia showed that the lowest eGFR quartiles estimated by MDRD and CG were significantly associated with DH compared to the highest eGFR quartile (adjusted odds ratio (aOR), 1.96; 95% CI, 1.22–3.14 by CG, 1.86; 95% CI, 1.17–2.96 by MDRD). Conclusion: Renal function impairment was independently associated with a higher prevalence of DH in a South Korean population.

Original languageEnglish
JournalJournal of Glaucoma
DOIs
Publication statusAccepted/In press - 2018 Jan 4

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Republic of Korea
Optic Disk
Glomerular Filtration Rate
Diet Therapy
Hemorrhage
Kidney
Creatinine
Logistic Models
Photography
Health
Hyperlipidemias
Nerve Fibers
Physical Examination
Cross-Sectional Studies
Odds Ratio
Regression Analysis
Hypertension
Serum
Population

Keywords

  • disc hemorrhage
  • glaucoma
  • kidney function

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Lee, J. Y., Kim, J. M., Shim, S. H., Lee, J. Y., Yoo, C., Song, J. Y., ... Park, K. H. (Accepted/In press). Association Between Optic Disc Hemorrhage and Renal Function in South Korea. Journal of Glaucoma. https://doi.org/10.1097/IJG.0000000000000871

Association Between Optic Disc Hemorrhage and Renal Function in South Korea. / Lee, Jae Yeun; Kim, Joon Mo; Shim, Seong Hee; Lee, Jin Young; Yoo, Chungkwon; Song, Ji Yoon; Won, Yu Sam; Hyun, Young Youl; Park, Ki Ho.

In: Journal of Glaucoma, 04.01.2018.

Research output: Contribution to journalArticle

Lee, Jae Yeun ; Kim, Joon Mo ; Shim, Seong Hee ; Lee, Jin Young ; Yoo, Chungkwon ; Song, Ji Yoon ; Won, Yu Sam ; Hyun, Young Youl ; Park, Ki Ho. / Association Between Optic Disc Hemorrhage and Renal Function in South Korea. In: Journal of Glaucoma. 2018.
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abstract = "Purpose: To investigate the relationship between renal function and disc hemorrhage (DH). Methods: This retrospective cross-sectional survey was conducted at Kangbuk Samsung Hospital Health Screening Center between August 2012 and July 2013, and a total of 168,044 participants at least 20 years of age who voluntarily visited the health screening center for systemic and ophthalmologic examinations, including fundus photography, were enrolled. All subjects underwent a physical examination and provided samples for laboratory analysis. Digital fundus photographs of both eyes were taken and reviewed. Estimated glomerular filtration rate (eGFR) was calculated from serum creatinine concentration using the Modification of Diet in Renal Disease (MDRD) formula and Cockcroft-Gault (CG) formula. Subjects were stratified by eGFR into quartiles. Results: Among participants, 220 (0.1{\%}) showed DH, and 2,376 (1.6{\%}) showed glaucomatous retinal nerve fiber layer (RNFL) defects. The DH group showed higher creatinine and lower eGFR than the non-DH group. A significant trend was observed among higher creatinine, decreased eGFR as obtained by the MDRD and CG formulas, and the prevalence of DH (P for Trend ≤0.003, logistic regression analysis). A multiple logistic regression model adjusted for age, sex, hypertension, diabetes, and hyperlipidemia showed that the lowest eGFR quartiles estimated by MDRD and CG were significantly associated with DH compared to the highest eGFR quartile (adjusted odds ratio (aOR), 1.96; 95{\%} CI, 1.22–3.14 by CG, 1.86; 95{\%} CI, 1.17–2.96 by MDRD). Conclusion: Renal function impairment was independently associated with a higher prevalence of DH in a South Korean population.",
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