Association between painful physical symptoms and clinical outcomes in Korean patients with major depressive disorder: A three-month observational study

Min-Soo Lee, Sun Young Yum, Jin Pyo Hong, Se Chang Yoon, Jai Sung Noh, Kwang Hun Lee, Jung Ki Kim, Sang Yeol Lee, Pritibha Singh, Tamas Treuer, Victoria Reed, Joel Raskin

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5 Citations (Scopus)

Abstract

Objective: This paper aims to examine the association between painful physical symptoms (PPS) and major depressive disorder (MDD) in a naturalistic clinical practice setting within a Korean population. Methods: Patients with acute MDD that joined a multicountry, observational, three-month study in six Asian countries and regions were classified as PPS+ (mean score ≥2) and PPS-(mean score <2) using the modified Somatic Symptom Inventory. In this analysis, we report the results from the Korean subset, where depression severity was assessed using the Clinical Global Impression of Severity (CGI-S) scale and 17-item Hamilton Depression Rating Scale (HAMD 17). Pain severity was measured using a visual analogue scale (VAS), while the EuroQoL (EQ-5D) assessed patient well-being. Results: Of 198 patients, 45.96% (91/198) of patients were classified as PPS+, of which 78.02% (71/91) were women. PPS+ patients had significantly more severe depression at baseline {CGI-S score, mean [standard deviation (SD)], PPS+: 5.09 [0.79]; PPS-: 4.63 [0.76]; p<0.001; HAMD 17 total score, mean [SD], PPS+: 24.34 [5.24]; PPS-: 20.76 [5.12]; p<0.001} and poorer quality of life [EQ-5D overall health state, mean (SD), PPS+: 39.37 (20.52); PPS-: 51.27 [20.78]; p<.001] than PPS- patients. Both groups improved significantly (p<0.001) in depression and pain severity outcomes, as well as quality of life by endpoint, but no significant within-group baseline-to-endpoint change wase observed. Conclusion: The frequency of PPS was common in Korean patients with MDD, and was associated with more severe depression, poorer quality of life, and a trend towards poorer clinical outcome.

Original languageEnglish
Pages (from-to)255-263
Number of pages9
JournalPsychiatry Investigation
Volume6
Issue number4
DOIs
Publication statusPublished - 2009 Dec 1

Keywords

  • Culture
  • Depression
  • Depressive disorder
  • Korea
  • Major
  • Pain
  • Quality of life

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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  • Cite this

    Lee, M-S., Yum, S. Y., Hong, J. P., Yoon, S. C., Noh, J. S., Lee, K. H., Kim, J. K., Lee, S. Y., Singh, P., Treuer, T., Reed, V., & Raskin, J. (2009). Association between painful physical symptoms and clinical outcomes in Korean patients with major depressive disorder: A three-month observational study. Psychiatry Investigation, 6(4), 255-263. https://doi.org/10.4306/pi.2009.6.4.255