Abstract
Background: The role of passive smoking on cervical carcinogenesis remains controversial. We investigated the association of passive smoking with the risk of cervical intraepithelial neoplasia (CIN) and cervical cancer. Methods: The study recruited 1,322 women, aged 18–65 with normal cytology (n = 592), CIN1 (n = 420), CIN2/3 (n = 165), and cervical cancer (n = 145) from 2006 to 2009. This study is a cross-sectional analysis using the baseline data from the Korean human papillomavirus (HPV) cohort study. Detailed information on smoking behaviors and lifestyles were collected using questionnaires. Multinomial logistic regression analysis was performed to estimate multivariable-adjusted odds ratios (ORs). Results: Passive smoking was not statistically related to the risk of CINs and cervical cancer. However, passive smoking among non-smokers was associated with higher CIN 1 risk (OR 1.53; 95% confidence interval [CI], 1.07–2.18), compared to not passive smoking, after adjusting for demographic factors, lifestyles, and oncogenic-HPV infection status. CIN 1 risk increased with longer time exposed to passive smoking (P for trend <0.0003). Multivariate odds of <2 hours/day of passive smoking and that of ≥2 hours/day of passive smoking were 2.48 (95% CI, 1.49–4.14) and 2.28 (95% CI, 1.21–4.26) for CIN 1, compared to not passive smoking. Conclusions: This study found that passive smoking among non-smoking women is associated with the risk of CIN 1.
| Original language | English |
|---|---|
| Pages (from-to) | 48-53 |
| Number of pages | 6 |
| Journal | Journal of Epidemiology |
| Volume | 28 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2018 Jan 1 |
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Keywords
- cervical cancer
- cervical intraepithelial neoplasia
- passive smoking
- smoking
ASJC Scopus subject areas
- Epidemiology
Cite this
Association Between Passive Smoking and the Risk of Cervical Intraepithelial Neoplasia 1 in Korean Women. / Min, Kyung Jin; Lee, Jae Kwan; So, Kyeong A.; Kim, Mi Kyung.
In: Journal of Epidemiology, Vol. 28, No. 1, 01.01.2018, p. 48-53.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association Between Passive Smoking and the Risk of Cervical Intraepithelial Neoplasia 1 in Korean Women
AU - Min, Kyung Jin
AU - Lee, Jae Kwan
AU - So, Kyeong A.
AU - Kim, Mi Kyung
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Background: The role of passive smoking on cervical carcinogenesis remains controversial. We investigated the association of passive smoking with the risk of cervical intraepithelial neoplasia (CIN) and cervical cancer. Methods: The study recruited 1,322 women, aged 18–65 with normal cytology (n = 592), CIN1 (n = 420), CIN2/3 (n = 165), and cervical cancer (n = 145) from 2006 to 2009. This study is a cross-sectional analysis using the baseline data from the Korean human papillomavirus (HPV) cohort study. Detailed information on smoking behaviors and lifestyles were collected using questionnaires. Multinomial logistic regression analysis was performed to estimate multivariable-adjusted odds ratios (ORs). Results: Passive smoking was not statistically related to the risk of CINs and cervical cancer. However, passive smoking among non-smokers was associated with higher CIN 1 risk (OR 1.53; 95% confidence interval [CI], 1.07–2.18), compared to not passive smoking, after adjusting for demographic factors, lifestyles, and oncogenic-HPV infection status. CIN 1 risk increased with longer time exposed to passive smoking (P for trend <0.0003). Multivariate odds of <2 hours/day of passive smoking and that of ≥2 hours/day of passive smoking were 2.48 (95% CI, 1.49–4.14) and 2.28 (95% CI, 1.21–4.26) for CIN 1, compared to not passive smoking. Conclusions: This study found that passive smoking among non-smoking women is associated with the risk of CIN 1.
AB - Background: The role of passive smoking on cervical carcinogenesis remains controversial. We investigated the association of passive smoking with the risk of cervical intraepithelial neoplasia (CIN) and cervical cancer. Methods: The study recruited 1,322 women, aged 18–65 with normal cytology (n = 592), CIN1 (n = 420), CIN2/3 (n = 165), and cervical cancer (n = 145) from 2006 to 2009. This study is a cross-sectional analysis using the baseline data from the Korean human papillomavirus (HPV) cohort study. Detailed information on smoking behaviors and lifestyles were collected using questionnaires. Multinomial logistic regression analysis was performed to estimate multivariable-adjusted odds ratios (ORs). Results: Passive smoking was not statistically related to the risk of CINs and cervical cancer. However, passive smoking among non-smokers was associated with higher CIN 1 risk (OR 1.53; 95% confidence interval [CI], 1.07–2.18), compared to not passive smoking, after adjusting for demographic factors, lifestyles, and oncogenic-HPV infection status. CIN 1 risk increased with longer time exposed to passive smoking (P for trend <0.0003). Multivariate odds of <2 hours/day of passive smoking and that of ≥2 hours/day of passive smoking were 2.48 (95% CI, 1.49–4.14) and 2.28 (95% CI, 1.21–4.26) for CIN 1, compared to not passive smoking. Conclusions: This study found that passive smoking among non-smoking women is associated with the risk of CIN 1.
KW - cervical cancer
KW - cervical intraepithelial neoplasia
KW - passive smoking
KW - smoking
UR - http://www.scopus.com/inward/record.url?scp=85040736593&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85040736593&partnerID=8YFLogxK
U2 - 10.2188/jea.JE20160118
DO - 10.2188/jea.JE20160118
M3 - Article
C2 - 29093300
AN - SCOPUS:85040736593
VL - 28
SP - 48
EP - 53
JO - Journal of Epidemiology
JF - Journal of Epidemiology
SN - 0917-5040
IS - 1
ER -