Association between percent-free prostate-specific antigen and glomerular filtration rate in transrectal ultrasound-guided biopsy-proven patients with prostate-specific antigen levels ranging from 4 to 10 ng/ml

Jae Heon Kim, Ji Sung Shim, Jae Hyun Bae, Hong Seok Park, Du Geon Moon, Soon Sun Kwon, Jae Young Park

Research output: Contribution to journalReview article

Abstract

Purpose: The aim of this study was to investigate the relationship between percent-free prostate-specific antigen (PSA) and estimated glomerular filtration rate (GFR) in men whose PSA level was 4-10 ng/ml with biopsy-proven prostate status. Methods: Between 2004 and 2010, the medical records of 495 cases (404 cases without prostate cancer and 91 cases with prostate cancer) who underwent prostate biopsy were reviewed and their GFR was calculated using the Cockcroft-Gault equation, adjusted for body surface area. Correlation and multivariate regression analyses were conducted among percent-free PSA, body mass index, prostate size, and GFR in patients with and without prostate cancer, respectively. Results: The mean patient age was 64. 6 years, and the median PSA and free PSA were 5. 64 and 0. 87 ng/ml. The mean GFR was 61. 02 mL/min/1. 73 m2, and mean percent-free PSA was 18. 9 %. Correlation analysis showed that percent-free PSA was correlated with GFR, age, and prostate size in the non-cancer cohort and correlated with only prostate size in the cancer cohort. Multivariate regression analysis showed that percent-free PSA was influenced by GFR (p < 0. 001) and prostate size (p < 0. 001) independently in the non-cancer cohort, while only by prostate size (p = 0. 008) in the cancer cohort. Conclusions: Percent-free PSA has a negative relationship with GFR in the benign prostate group, while it does not in the prostate cancer group. Screening with current cutoff value of percent-free PSA can be applied to the patients with impaired renal function.

Original languageEnglish
Pages (from-to)313-318
Number of pages6
JournalWorld Journal of Urology
Volume31
Issue number2
DOIs
Publication statusPublished - 2013 Jan 3

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Prostate-Specific Antigen
Glomerular Filtration Rate
Prostate
Biopsy
Prostatic Neoplasms
Multivariate Analysis
Regression Analysis
Body Surface Area
Medical Records
Neoplasms
Body Mass Index
Kidney

Keywords

  • Chronic kidney disease
  • Diagnosis
  • Prostate-specific antigen
  • Prostatic neoplasms

ASJC Scopus subject areas

  • Urology

Cite this

@article{67d38d01d0b1467198334fd72a4c3fa2,
title = "Association between percent-free prostate-specific antigen and glomerular filtration rate in transrectal ultrasound-guided biopsy-proven patients with prostate-specific antigen levels ranging from 4 to 10 ng/ml",
abstract = "Purpose: The aim of this study was to investigate the relationship between percent-free prostate-specific antigen (PSA) and estimated glomerular filtration rate (GFR) in men whose PSA level was 4-10 ng/ml with biopsy-proven prostate status. Methods: Between 2004 and 2010, the medical records of 495 cases (404 cases without prostate cancer and 91 cases with prostate cancer) who underwent prostate biopsy were reviewed and their GFR was calculated using the Cockcroft-Gault equation, adjusted for body surface area. Correlation and multivariate regression analyses were conducted among percent-free PSA, body mass index, prostate size, and GFR in patients with and without prostate cancer, respectively. Results: The mean patient age was 64. 6 years, and the median PSA and free PSA were 5. 64 and 0. 87 ng/ml. The mean GFR was 61. 02 mL/min/1. 73 m2, and mean percent-free PSA was 18. 9 {\%}. Correlation analysis showed that percent-free PSA was correlated with GFR, age, and prostate size in the non-cancer cohort and correlated with only prostate size in the cancer cohort. Multivariate regression analysis showed that percent-free PSA was influenced by GFR (p < 0. 001) and prostate size (p < 0. 001) independently in the non-cancer cohort, while only by prostate size (p = 0. 008) in the cancer cohort. Conclusions: Percent-free PSA has a negative relationship with GFR in the benign prostate group, while it does not in the prostate cancer group. Screening with current cutoff value of percent-free PSA can be applied to the patients with impaired renal function.",
keywords = "Chronic kidney disease, Diagnosis, Prostate-specific antigen, Prostatic neoplasms",
author = "Kim, {Jae Heon} and Shim, {Ji Sung} and Bae, {Jae Hyun} and Park, {Hong Seok} and Moon, {Du Geon} and Kwon, {Soon Sun} and Park, {Jae Young}",
year = "2013",
month = "1",
day = "3",
doi = "10.1007/s00345-012-1012-0",
language = "English",
volume = "31",
pages = "313--318",
journal = "World Journal of Urology",
issn = "0724-4983",
publisher = "Springer Verlag",
number = "2",

}

TY - JOUR

T1 - Association between percent-free prostate-specific antigen and glomerular filtration rate in transrectal ultrasound-guided biopsy-proven patients with prostate-specific antigen levels ranging from 4 to 10 ng/ml

AU - Kim, Jae Heon

AU - Shim, Ji Sung

AU - Bae, Jae Hyun

AU - Park, Hong Seok

AU - Moon, Du Geon

AU - Kwon, Soon Sun

AU - Park, Jae Young

PY - 2013/1/3

Y1 - 2013/1/3

N2 - Purpose: The aim of this study was to investigate the relationship between percent-free prostate-specific antigen (PSA) and estimated glomerular filtration rate (GFR) in men whose PSA level was 4-10 ng/ml with biopsy-proven prostate status. Methods: Between 2004 and 2010, the medical records of 495 cases (404 cases without prostate cancer and 91 cases with prostate cancer) who underwent prostate biopsy were reviewed and their GFR was calculated using the Cockcroft-Gault equation, adjusted for body surface area. Correlation and multivariate regression analyses were conducted among percent-free PSA, body mass index, prostate size, and GFR in patients with and without prostate cancer, respectively. Results: The mean patient age was 64. 6 years, and the median PSA and free PSA were 5. 64 and 0. 87 ng/ml. The mean GFR was 61. 02 mL/min/1. 73 m2, and mean percent-free PSA was 18. 9 %. Correlation analysis showed that percent-free PSA was correlated with GFR, age, and prostate size in the non-cancer cohort and correlated with only prostate size in the cancer cohort. Multivariate regression analysis showed that percent-free PSA was influenced by GFR (p < 0. 001) and prostate size (p < 0. 001) independently in the non-cancer cohort, while only by prostate size (p = 0. 008) in the cancer cohort. Conclusions: Percent-free PSA has a negative relationship with GFR in the benign prostate group, while it does not in the prostate cancer group. Screening with current cutoff value of percent-free PSA can be applied to the patients with impaired renal function.

AB - Purpose: The aim of this study was to investigate the relationship between percent-free prostate-specific antigen (PSA) and estimated glomerular filtration rate (GFR) in men whose PSA level was 4-10 ng/ml with biopsy-proven prostate status. Methods: Between 2004 and 2010, the medical records of 495 cases (404 cases without prostate cancer and 91 cases with prostate cancer) who underwent prostate biopsy were reviewed and their GFR was calculated using the Cockcroft-Gault equation, adjusted for body surface area. Correlation and multivariate regression analyses were conducted among percent-free PSA, body mass index, prostate size, and GFR in patients with and without prostate cancer, respectively. Results: The mean patient age was 64. 6 years, and the median PSA and free PSA were 5. 64 and 0. 87 ng/ml. The mean GFR was 61. 02 mL/min/1. 73 m2, and mean percent-free PSA was 18. 9 %. Correlation analysis showed that percent-free PSA was correlated with GFR, age, and prostate size in the non-cancer cohort and correlated with only prostate size in the cancer cohort. Multivariate regression analysis showed that percent-free PSA was influenced by GFR (p < 0. 001) and prostate size (p < 0. 001) independently in the non-cancer cohort, while only by prostate size (p = 0. 008) in the cancer cohort. Conclusions: Percent-free PSA has a negative relationship with GFR in the benign prostate group, while it does not in the prostate cancer group. Screening with current cutoff value of percent-free PSA can be applied to the patients with impaired renal function.

KW - Chronic kidney disease

KW - Diagnosis

KW - Prostate-specific antigen

KW - Prostatic neoplasms

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U2 - 10.1007/s00345-012-1012-0

DO - 10.1007/s00345-012-1012-0

M3 - Review article

VL - 31

SP - 313

EP - 318

JO - World Journal of Urology

JF - World Journal of Urology

SN - 0724-4983

IS - 2

ER -