Association between restless legs syndrome and CLOCK and NPAS2 gene polymorphisms in schizophrenia

Jin Sook Jung, Heon-Jeong Lee, Chul Hyun Cho, Seung Gul Kang, Ho-Kyoung Yoon, Young Min Park, Joung Ho Moon, Hee Jung Yang, Hyun Mi Song, Leen Kim

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Abstract

Previous studies have suggested that there is a genetic basis to restless legs syndrome (RLS) development. Occurrence of antipsychotic-induced RLS could also be due to differences in genetic susceptibility. We investigated whether CLOCK and NPAS2 gene polymorphisms are associated with RLS in schizophrenic patients on antipsychotics because RLS symptoms usually manifest during the evening and night. We assessed symptoms of RLS in 190 Korean schizophrenic patients on antipsychotics and divided the subjects into two groups according to the International Restless Legs Syndrome Study Group diagnostic criteria: (i) subjects who met all the criteria and (ii) the remaining subjects who did not meet all the criteria. We found a significant difference in the number of subjects with different genotype and allele carrier frequencies for the CLOCK gene (rs2412646) between the two groups (p = 0.031 and 0.010, respectively). Distribution of CLOCK haplotypes (rs2412646-rs1801260) was significantly different between schizophrenic patients with and without RLS (p = 0.021). However, the distributions of allelic, genotypic, and haplotypic variants of NPAS2 (rs2305160 and rs6725296) were not significantly different between the two groups. Our results suggest that CLOCK polymorphisms are associated with increased susceptibility of schizophrenic patients to RLS. We hypothesize that RLS in schizophrenia patients treated with antipsychotics may be a very mild akathisia that manifests during the night and is under control of circadian oscillation.

Original languageEnglish
Pages (from-to)838-844
Number of pages7
JournalChronobiology International
Volume31
Issue number7
DOIs
Publication statusPublished - 2014 Jan 1

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Restless Legs Syndrome
Schizophrenia
Genes
Antipsychotic Agents
Psychomotor Agitation
Genetic Predisposition to Disease
Gene Frequency
Haplotypes
Genotype

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Association between restless legs syndrome and CLOCK and NPAS2 gene polymorphisms in schizophrenia. / Jung, Jin Sook; Lee, Heon-Jeong; Cho, Chul Hyun; Kang, Seung Gul; Yoon, Ho-Kyoung; Park, Young Min; Moon, Joung Ho; Yang, Hee Jung; Song, Hyun Mi; Kim, Leen.

In: Chronobiology International, Vol. 31, No. 7, 01.01.2014, p. 838-844.

Research output: Contribution to journalArticle

Jung, Jin Sook ; Lee, Heon-Jeong ; Cho, Chul Hyun ; Kang, Seung Gul ; Yoon, Ho-Kyoung ; Park, Young Min ; Moon, Joung Ho ; Yang, Hee Jung ; Song, Hyun Mi ; Kim, Leen. / Association between restless legs syndrome and CLOCK and NPAS2 gene polymorphisms in schizophrenia. In: Chronobiology International. 2014 ; Vol. 31, No. 7. pp. 838-844.
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