Association between rs1800795 polymorphisms in the interleukin-6 gene and vasculitis: A meta-analysis

Jae Hyun Jung, Hongdeok Seok, Sung Jae Choi, Gwan Gyu Song, Youngjin Han

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)

    Abstract

    Interleukin (IL)-6 is associated with the development and progression of vasculitis, and inhibitors of this cytokine are used to treat this disease. Polymorphisms of the promoter region of IL-6 are associated with the production and expression of IL-6. The aim of this study was to perform a meta-analysis of eligible studies to derive a precise estimate of the association between IL6 polymorphisms and susceptibility to vasculitis. A meta-analysis was conducted to identify the associations between IL6 rs1800795 (-174 G/C) polymorphisms and vasculitis. A total of 13 studies involving 1,294 vasculitis patients and 1,594 controls were considered in the meta-analysis. There were significant associations between IL6 rs1800795 polymorphisms and vasculitis in allele contrast, dominant genetic model, and heterozygote vs. dominant homozygote comparison (OR 0.80, 95% CI 0.67-0.94, P =0.009 and OR 0.76, 95% CI 0.63-0.92, P =0.005, respectively). In subgroup analysis based on subtype, there were significant associations between IL6 polymorphisms and susceptibility in large and medium vessel vasculitis, but not in small and variable vessel vasculitis. The GC genotype of IL6 rs1800795 was suggested by the analyses to be related to low prevalence of vasculitis, especially for large and medium vessels.

    Original languageEnglish
    Pages (from-to)302-310
    Number of pages9
    JournalSarcoidosis Vasculitis and Diffuse Lung Diseases
    Volume36
    Issue number4
    DOIs
    Publication statusPublished - 2019 Dec 18

    Keywords

    • Interleukin-6
    • Meta-analysis
    • Polymorphism
    • Vasculitis

    ASJC Scopus subject areas

    • Internal Medicine
    • Immunology and Allergy
    • Pulmonary and Respiratory Medicine

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