Association between Several Persistent Organic Pollutants in Serum and Adipokine Levels in Breast Milk among Lactating Women of Korea

Sunmi Kim, Jeongim Park, Hai Joong Kim, Jeong Jae Lee, Gyuyeon Choi, Sooran Choi, Sungjoo Kim, Su Young Kim, Duk Hee Lee, Hyo Bang Moon, Sungkyoon Kim, Kyungho Choi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

(Figure Presented). Exposure to several persistent organic pollutants (POPs) has been linked to alteration of lipid metabolism. Adipokines, such as leptin and adiponectin, are hormones that play roles in lipid metabolism, and have been suggested as markers of health effects that may lead to obesity. To date, only serum adipokines have been associated with POPs exposure. In the present study, for the first time, the associations between leptin and adiponectin in breast milk, and several POPs in serum were investigated among 82 lactating Korean women between 25 and 46 years of age. Breast milk adipokines are important because adipokine intake of infant through breastfeeding may influence the growth of infants. The median concentrations of leptin and adiponectin in skimmed milk of the Korean lactating women were 17.9 ng/L and 16.5 μg/L, respectively. Leptin concentrations in breast milk were negatively associated with Σhexachlorohexane (HCH), oxychlordane, Σchlordane, or 2,2′,4,4′,5,5′-hexachlorobiphenyl (CB 153) levels in maternal serum. Linear relationships between adiponectin and POPs concentrations were not observed, however, nonmonotonic relationship which showed generally positive associations was suggested for p,p′-dichlorodiphenyltrichloroethane (DDT) and Σchlordane in quartile analysis. Our observations show that POPs at the current level of exposure may be associated with the alteration of lipid metabolism among lactating women. Implication of adipokine transfer to breastfed infants is of concern and deserves further investigation.

Original languageEnglish
Pages (from-to)8033-8040
Number of pages8
JournalEnvironmental Science and Technology
Volume49
Issue number13
DOIs
Publication statusPublished - 2015 Jul 7

Fingerprint

Adipokines
Organic pollutants
Human Milk
Korea
2,4,5,2',4',5'-hexachlorobiphenyl
Adiponectin
serum
Leptin
Lipid Metabolism
Chlordan
Serum
chlordane
metabolism
lipid
breastfeeding
obesity
Breast Feeding
DDT
milk
hormone

ASJC Scopus subject areas

  • Chemistry(all)
  • Environmental Chemistry

Cite this

Association between Several Persistent Organic Pollutants in Serum and Adipokine Levels in Breast Milk among Lactating Women of Korea. / Kim, Sunmi; Park, Jeongim; Kim, Hai Joong; Lee, Jeong Jae; Choi, Gyuyeon; Choi, Sooran; Kim, Sungjoo; Kim, Su Young; Lee, Duk Hee; Moon, Hyo Bang; Kim, Sungkyoon; Choi, Kyungho.

In: Environmental Science and Technology, Vol. 49, No. 13, 07.07.2015, p. 8033-8040.

Research output: Contribution to journalArticle

Kim, Sunmi ; Park, Jeongim ; Kim, Hai Joong ; Lee, Jeong Jae ; Choi, Gyuyeon ; Choi, Sooran ; Kim, Sungjoo ; Kim, Su Young ; Lee, Duk Hee ; Moon, Hyo Bang ; Kim, Sungkyoon ; Choi, Kyungho. / Association between Several Persistent Organic Pollutants in Serum and Adipokine Levels in Breast Milk among Lactating Women of Korea. In: Environmental Science and Technology. 2015 ; Vol. 49, No. 13. pp. 8033-8040.
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AB - (Figure Presented). Exposure to several persistent organic pollutants (POPs) has been linked to alteration of lipid metabolism. Adipokines, such as leptin and adiponectin, are hormones that play roles in lipid metabolism, and have been suggested as markers of health effects that may lead to obesity. To date, only serum adipokines have been associated with POPs exposure. In the present study, for the first time, the associations between leptin and adiponectin in breast milk, and several POPs in serum were investigated among 82 lactating Korean women between 25 and 46 years of age. Breast milk adipokines are important because adipokine intake of infant through breastfeeding may influence the growth of infants. The median concentrations of leptin and adiponectin in skimmed milk of the Korean lactating women were 17.9 ng/L and 16.5 μg/L, respectively. Leptin concentrations in breast milk were negatively associated with Σhexachlorohexane (HCH), oxychlordane, Σchlordane, or 2,2′,4,4′,5,5′-hexachlorobiphenyl (CB 153) levels in maternal serum. Linear relationships between adiponectin and POPs concentrations were not observed, however, nonmonotonic relationship which showed generally positive associations was suggested for p,p′-dichlorodiphenyltrichloroethane (DDT) and Σchlordane in quartile analysis. Our observations show that POPs at the current level of exposure may be associated with the alteration of lipid metabolism among lactating women. Implication of adipokine transfer to breastfed infants is of concern and deserves further investigation.

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